Module S3.07 - Theranostics

Coordinator

Prof. Dr. Adrian Press

Lecturers

Prof. Dr. Adrian Press, Dr. Philipp Ernst

Schedule

Lectures: every Monday 10.00 - 12.00 (see below), starting on Oct 16th.
Seminars: every second Monday 12.00-14.00
Location: SR 12* Forschungszentrum Lobeda (FZL Building, Scientific Center; Lobeda University Hospital)
*: on 22nd of January 2024: SR 15
if you intend to participate in this module and registration with Friedolin does not work, please send an e-mail to

Essential to an efficient therapy of many diseases is a precise diagnosis and a selective application of potent therapeutic agents. To this aim imaging methods have been improved, and strategies for targeted delivery and localized activation of therapeutic agents have been developped.

Theranostic approaches try to combine diagnostic and therapeutic techniques by synthesizing carrier systems capable of specific targeting and carrying imaging and therapeutic agents for accurate diagnosis and controlled release. This course introduces the student into current techniques and therapeutic applications.

Topics covered in the course are:

Theranostics: Definition and Introduction
Dyes, fluorophores and nanomaterials for light-based diagnostic applications
Photodynamic therapy, photosensitizers
Photothermal therapy
Theranostic nanocarriers
- Design principles of carrier structures
- Targeting strategies
- Diagnostic and therapeutic agents

Week	Title	Aim	Lecturer
1	Introduction	Activate knowledge of the participants and engage in a discussion and learing about the terminology	Press
2	When do we treat?	Understanding the dilemma of Theranostics and end-of-life descisions. Meet clinical needs.	Press
3	Nanomedicine I - Introduction	Engaging in the translational questions of nanomedicine. Which materials are available? How does it work? How can Nanomedicine be superior to conventional pharmacology?	Press

4	Nanomedicine II - The cellular and physiologic basis	Learn about how nanocarrier interact with the body? What need to be considered when designing drug-delivery systems and how may a "tissue-specific" drug delivery be acchieved?	Press
5	Nanomedicine III - Cellular Basics	Molecular Mechanism of Nanomedicine: endocytosis, inflamamtory reaction, mechanism of immune reaction	Press
6	Nanomedicine IV - Nanotheranostics	Why there is so little nanomedicine yet? How can nanomedicine become more successful? Bottlenecks and novel Photonic solutions.	Press

7	Theranostic Antibiotics - clinical need, microbiological background	Clinical Need? How do antibiotics kill bacteria? What is "resistance"? What are current clinical limitations?	Press
8	Theranostic Antibiotics - diagnosics	Understanding methods to identify bacteria and resisteance using biophotonics.	Press
9	Theranostic Antibiotics - therapeutics	How do antibiotics kill bacteria? How	Press

10	Theranostics - Oncology I	to be announced	Ernst
11	Theranostics - Oncology II	to be announced	Ernst
12	Theranostics - Oncology III	to be announced	Ernst
	Q&A	Review and final xame preparation	Press

Requirements to complete the module:

written exam at the end of the semeseter

Exam dates

to be announced in the lecture