Medical Photonics / Semester information / Winter term 2022/2023 / 3rd semester / Module S3.07 - Theranostics
Module S3.07 - Theranostics
Coordinator
Prof. Dr. Adrian Press
Lecturers
Prof. Dr. Adrian Press, Dr. Philipp Ernst, Wanling Foo
Schedule
- Lectures: every Monday 10.00 - 12.00 (see below), starting on Oct 17th.
- Seminars: every second Monday 12.00-14.00
- Location: SR 12 Forschungszentrum Lobeda (FZL Building, Scientific Center; Lobeda University Hospital)
- if you intend to participate in this module and registration with Friedolin does not work, please send an e-mail to
Contents
Essential to an efficient therapy of many diseases is a precise diagnosis and a selective application of potent therapeutic agents. To this aim imaging methods have been improved, and strategies for targeted delivery and localized activation of therapeutic agents have been developped.
Theranostic approaches try to combine diagnostic and therapeutic techniques by synthesizing carrier systems capable of specific targeting and carrying imaging and therapeutic agents for accurate diagnosis and controlled release. This course introduces the student into current techniques and therapeutic applications.
Topics covered in the course are:
- Theranostics: Definition and Introduction
- Dyes, fluorophores and nanomaterials for light-based diagnostic applications
- Photodynamic therapy, photosensitizers
- Photothermal therapy
- Theranostic nanocarriers
- Design principles of carrier structures
- Targeting strategies
- Diagnostic and therapeutic agents
Week | Title | Aim | Lecturer |
1 | Introduction | Activate knowledge of the participants and engage in a discussion and learing about the terminology | Press |
2 | When do we treat? | Understanding the dilemma of Theranostics and end-of-life descisions. Meet clinical needs. | Press |
3 | Nanomedicine I - Introduction | Engaging in the translational questions of nanomedicine. Which materials are available? How does it work? How can Nanomedicine be superior to conventional pharmacology? | Press |
4 | Nanomedicine II - The cellular and physiologic basis | Learn about how nanocarrier interact with the body? What need to be considered when designing drug-delivery systems and how may a "tissue-specific" drug delivery be acchieved? | Foo |
5 | Nanomedicine III - Cellular Basics | Molecular Mechanism of Nanomedicine: endocytosis, inflamamtory reaction, mechanism of immune reaction | Foo |
6 | Nanomedicine IV - Nanotheranostics | Why there is so little nanomedicine yet? How can nanomedicine become more successful? Bottlenecks and novel Photonic solutions. | Foo |
7 | Theranostic Antibiotics - clinical need, microbiological background | Clinical Need? How do antibiotics kill bacteria? What is "resistance"? What are current clinical limitations? | Press |
8 | Theranostic Antibiotics - diagnosics | Understanding methods to identify bacteria and resisteance using biophotonics. | Press |
9 | Theranostic Antibiotics - therapeutics | How do antibiotics kill bacteria? How | Press |
10 | Theranostics - Oncology I | to be announced | Ernst |
11 | Theranostics - Oncology II | to be announced | Ernst |
12 | Theranostics - Oncology III | to be announced | Ernst |
Q&A | Review and final xame preparation | Press |
Requirements to complete the module:
- written exam at the end of the semeseter
Exam dates
- to be announced in the lecture