The autonomic nervous system (ANS) plays a dominant role for the complex control of multiple vitally important physiological subsystems in the organism. Its activity is reflected in heart rate variability (HRV) characteristics.
Fetal magnetocardiographic recordings provide a resulting unique methodology of prenatal diagnosis with regard to the identification of fetal maturation disturbances with instantaneous prenatal consequences as well as the "fetal programming" of diseases in later postnatal age, such as cardiovascular, metabolic, hyperkinetic, cognitive and behavioral problems.
Another research area is the instantaneous risk assessment and identification of developing infections/sepsis by means of HRV indices due to the ANS involvement in the immune system function.
Fetal maturation and risk assessment
Database of fetal normal development: fetal heart rate variability (fHRV) under consideration of fetal age and behavioral state.
Design and evaluation of fHRV indices with respect to ANS functional structure and universal developmental rules of complex systems.
Influence of pathological disturbances (intrauterine growth restriction) and treatment (glucocorticoids) to fHRV.
Postnatal outcome (one year, seven years).
Critical care risk assessment in adults
Study of predictive value of HRV after acute ischemic stroke for sub-acute infections and sepsis.
2016-2018: "Development of a clinical marker of fetal autonomic maturation" (German Research Foundation, DFG: Ho 1634/15-12)
2010-2014: "Autonomic markers of stroke-induced immunosuppression and risk of infection, PRED-SEP" (Center for Sepsis Control and Care CSCC, BMBF: 01 E0 1002)
2009-2011: "Prenatal diagnosis-Indices of fetal developmental disturbances enabled by advanced signal identification techniques" (Marie Curie Intra-European Fellowship, Proposal No 237290)
2007-2010: "Biomagnetic investigations of fetal autonomic and central nervous maturation and its disturbances due to intrauterine growth restriction and glucocorticoide administration" (DFG: Ho 1634/12-2, Schn 775/2-3)
2003-2008: "Investigation of maturation of complex autonomic control in heart rate dynamics and its pathophysiological disturbances by fetal magnetocardiography" (DFG: Ho 1634/9-1,2)
2002-2005: "Mechanisms, characterization and age dependency of cardiovascular autonomic dysfunction of critically ill patients" (DFG: Ho 1634/8-1,2)
2001-2003: "Complexity as a tool which characterizes neurovegetative dynamics during severe disturbances of brain function" (DFG: Zwie 47/9-1)
1996-1998: "Nonlinear analysis of heart rate variability“ (TMWFK: B301 96091)
1996-1997: "Quantitative nonlinear parameters of physiological time series - applied to characterize the neurovegetative organization of respiration and heart rate" (PROCOPE: 312/pro-u-gg))
1992-1996: "Application of adaptive signal processing and classification to characterize complex brain dysfunctions during regional ischemia" (BMBF: 01 IN 202 F, in ADAPT "Adaptive therapy optimization")
Rafal Baranowski, National Institute of Cardiology, Warsaw, Poland
Bea Van Den Bergh, Faculty of Social and Behavioral Sciences - Tilburg University, the Netherlands; Health Psychology KU Leuven, Belgium
Pere Caminal, Technical University of Catalania, Barcelona, Spain
Ki H Chon, Biomedical Engineering Faculty, Worchester Polytechnic Institute, USA
Dirk Cysarz, Fakultät für Gesundheit, Department für Humanmedizin, Universität Witten/Herdecke
Ayres-de-Campos Diogo, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Porto, Portugal; Department of Obstetrics and Gynecology, São João Hospital, Portugal; INEB — Institute of Biomedical Engineering, Portugal
Luca Faes, University of Trento, Italy
Kathleen M Gustafson, Hoglund Brain Imaging Center, Dept. of Neurology, Medical Center, University of Kansas, USA
Patricia R E Harris, ECG Monitoring Research Laboratory School of Nursing, University of California, San Francisco, USA
Jens Haueisen, Institut für Biomedizinische Technik und Informatik, Technische Universität Ilmenau
Gonçalves Hernâni, CINTESIS, Faculty of Medicine, University of Porto, Porto, Portugal
Bernardes João, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Porto, Portugal; Department of Obstetrics and Gynecology, São João Hospital, Portugal
Peter van Leeuwen, Abteilung Biomagnetismus, Grönemeyer Institut für Mikrotherapie Bochum
R. Maestri, D.G. Pinna, M.T. LaRovere, S. Maugeri Foundation, IRCCS, Scientific Institute of Montescano, Italy
Alberto Porta, Department of Technologies for Health, University of Milan, Italy
Phyllis K Stein, Heart Rate Variability Laboratory, Washington University School of Medicine, St. Louis, USA
Andreas Voss, Fachbereich Medizintechnik und Biotechnologie, Ernst-Abbe-Fachhochschule Jena
Jan J Zebrowski, University of Technology, Warsaw, Poland