Biomagnetic Center - RG System Analysis
Head of Reseach Group System Analysis
phone: 03641 - 9 396 633
fax: 03641 - 9 325 772
- Dipl.-Ing. Samuel Nowack
Tel. 03641 - 9 396 633
PhD, Bachelor- and Master Students
- Josephine Adam
- Franziska Bode
- Dominik Friedmann
- Kathrin Kumm
- Isabelle Kynaß
- Sophia Leibl
- Fenja Meyer
- Carolin Michael
- Adelina Pytlik
- Ingo Salzmann
- Alexander Schmidt
- Janine Tegtmeyer
The autonomic nervous system (ANS) plays a dominant role for the complex control of multiple vitally important physiological subsystems in the organism. Its activity is reflected in heart rate variability (HRV) characteristics.
Fetal magnetocardiographic recordings provide a resulting unique methodology of prenatal diagnosis with regard to the identification of fetal maturation disturbances with instantaneous prenatal consequences as well as the "fetal programming" of diseases in later postnatal age, such as cardiovascular, metabolic, hyperkinetic, cognitive and behavioral problems.
Another research area is the instantaneous risk assessment and identification of developing infections/sepsis by means of HRV indices due to the ANS involvement in the immune system function.
Fetal maturation and risk assessment
- Database of fetal normal development: fetal heart rate variability (fHRV) under consideration of fetal age and behavioral state.
- Design and evaluation of fHRV indices with respect to ANS functional structure and universal developmental rules of complex systems.
- Influence of pathological disturbances (intrauterine growth restriction) and treatment (glucocorticoids) to fHRV.
- Postnatal outcome (one year, seven years).
Critical care risk assessment in adults
- Study of predictive value of HRV after acute ischemic stroke for sub-acute infections and sepsis.
2016-2018: "Development of a clinical marker of fetal autonomic maturation" (German Research Foundation, DFG: Ho 1634/15-12)
2010-2014: "Autonomic markers of stroke-induced immunosuppression and risk of infection, PRED-SEP" (Center for Sepsis Control and Care CSCC, BMBF: 01 E0 1002)
2009-2011: "Prenatal diagnosis-Indices of fetal developmental disturbances enabled by advanced signal identification techniques" (Marie Curie Intra-European Fellowship, Proposal No 237290)
2007-2010: "Biomagnetic investigations of fetal autonomic and central nervous maturation and its disturbances due to intrauterine growth restriction and glucocorticoide administration" (DFG: Ho 1634/12-2, Schn 775/2-3)
2003-2008: "Investigation of maturation of complex autonomic control in heart rate dynamics and its pathophysiological disturbances by fetal magnetocardiography" (DFG: Ho 1634/9-1,2)
2002-2005: "Mechanisms, characterization and age dependency of cardiovascular autonomic dysfunction of critically ill patients" (DFG: Ho 1634/8-1,2)
2001-2003: "Complexity as a tool which characterizes neurovegetative dynamics during severe disturbances of brain function" (DFG: Zwie 47/9-1)
1996-1998: "Nonlinear analysis of heart rate variability“ (TMWFK: B301 96091)
1996-1997: "Quantitative nonlinear parameters of physiological time series - applied to characterize the neurovegetative organization of respiration and heart rate" (PROCOPE: 312/pro-u-gg))
1992-1996: "Application of adaptive signal processing and classification to characterize complex brain dysfunctions during regional ischemia" (BMBF: 01 IN 202 F, in ADAPT "Adaptive therapy optimization")
University Hospital Jena
- Research group fetal biomagnetism (Head: Prof. Dr. med. Uwe Schneider) Department of gynaecology and obstetrics (Head: Prof. Dr. med. Ekkehard Schleußner)
- Department of neonatology and pediatric intensive care Pediatric clinic (Head: Prof. Dr. med. James Beck)
- Institute of Medical Statistics, Computer Sciences and Documentation (Head: Prof. Dr. Herbert Witte)
- Department of psychiatry and psychotherapy (Prof. Dr. K.-J. Bär)
- Department of pediatric psychiatry and psychotherapy (Dr. Carolin Ligges)
- Rafal Baranowski, National Institute of Cardiology, Warsaw, Poland
- Bea Van Den Bergh, Faculty of Social and Behavioral Sciences - Tilburg University, the Netherlands; Health Psychology KU Leuven, Belgium
- Pere Caminal, Technical University of Catalania, Barcelona, Spain
- Ki H Chon, Biomedical Engineering Faculty, Worchester Polytechnic Institute, USA
- Dirk Cysarz, Fakultät für Gesundheit, Department für Humanmedizin, Universität Witten/Herdecke
- Ayres-de-Campos Diogo, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Porto, Portugal; Department of Obstetrics and Gynecology, São João Hospital, Portugal; INEB — Institute of Biomedical Engineering, Portugal
- Luca Faes, University of Trento, Italy
- Kathleen M Gustafson, Hoglund Brain Imaging Center, Dept. of Neurology, Medical Center, University of Kansas, USA
- Patricia R E Harris, ECG Monitoring Research Laboratory School of Nursing, University of California, San Francisco, USA
- Jens Haueisen, Institut für Biomedizinische Technik und Informatik, Technische Universität Ilmenau
- Gonçalves Hernâni, CINTESIS, Faculty of Medicine, University of Porto, Porto, Portugal
- Bernardes João, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Porto, Portugal; Department of Obstetrics and Gynecology, São João Hospital, Portugal
- Peter van Leeuwen, Abteilung Biomagnetismus, Grönemeyer Institut für Mikrotherapie Bochum
- R. Maestri, D.G. Pinna, M.T. LaRovere, S. Maugeri Foundation, IRCCS, Scientific Institute of Montescano, Italy
- Alberto Porta, Department of Technologies for Health, University of Milan, Italy
- Phyllis K Stein, Heart Rate Variability Laboratory, Washington University School of Medicine, St. Louis, USA
- Andreas Voss, Fachbereich Medizintechnik und Biotechnologie, Ernst-Abbe-Fachhochschule Jena
- Jan J Zebrowski, University of Technology, Warsaw, Poland