Prof. Dr. Inken Hilgendorf (Group leader)
Klinik für Innere Medizin II
Abteilung Hämatologie und Internistische Onkologie
Universitätsklinikum Jena

Email:  

Group members

Sarah Maria Haberbosch (Doktorandin)
Kristin Pulewka (Dipl.-Psychologin)
Nora Kiconco Rath (Doktorandin)
Pauline Rocke (Doktorandin)
Dr. med. Charlotte Schmidt-Hieber (Fachärztin)
Lena Tandetzky (Doktorandin)

Research Focus

The treatment of malignant hematologic or oncologic diseases can contribute to the occurrence of long-term side effects. These long-term consequences often go hand in hand with an impaired quality of life for those affected. Adolescents and young adults (AYA) are particularly affected due to their young age at the time of the disease.

The focus of our interest is on investigations into immune reconstitution and the pathogenesis and therapy of graft-versus-host disease (GvHD) after allogeneic blood stem cell transplantation, as well as the assessment of long-term consequences after tumor or cell therapy, including the analysis of the effectiveness of preventive measures. In cooperation with the Department of Infection Immunology at the Leibniz Institute for Natural Product Research & Infection Biology, we are investigating the mechanisms of T cell regulation after allogeneic blood stem cell transplantation. As a partner of the BMBF-funded PRETTY consortium, we are actively involved in the establishment of a personalized PREdiction model of Transplant ToxicitY through federated learning from data, expert judgement and patient perspectives.

Publications (Selection)

1. von Grundherr J, Elmers S, Koch B, Hail LA, Mann J, Escherich G, Bergelt C, Samland L, Jensen W, Vettorazzi E, Stark M, Valentini L, Baumann FT, Singer S, Reer R, Beller R, Calaminus G, Faber J, Classen CF, Gebauer J, Hilgendorf I, Koehler M, Puzik A, Salzmann N, Sander A, Schiffmann L, Sokalska-Duhme M, Schuster S, Kock-Schoppenhauer AK, Bokemeyer C, Sinn M, Stein A, Dwinger S, Salchow J. A Multimodal Lifestyle Psychosocial Survivorship Program in Young Cancer Survivors: The CARE for CAYA Program-A Randomized Clinical Trial Embedded in a Longitudinal Cohort Study. JAMA Netw Open. 2024 Mar 4;7(3):e242375.
2. Sockel K, Neu A, Goeckenjan M, Ditschkowski M, Hilgendorf I, Kröger N, Ayuk FA, Stoelzel F, Middeke JM, Eder M, Bethge W, Finke J, Bertz H, Kobbe G, Kaufmann M, Platzbecker U, Beverungen D, Schmid C, von Bonin M, Egger-Heidrich K, Heberling L, Trautmann-Grill K, Teipel R, Bug G, Tischer J, Fraccaroli A, Fante M, Wolff D, Luft T, Winkler J, Schäfer-Eckart K, Scheid C, Holtick U, Klein S, Blau IW, Burchert A, Wulf G, Hasenkamp J, Schwerdtfeger R, Kaun S, Junghanss C, Wortmann F, Winter S, Neidlinger H, Theuser C, Beyersmann J, Bornhaeuser M, Schmeller S, Schetelig J. Hope for motherhood: pregnancy after allogeneic hematopoietic cell transplantation (a national multicenter study). Blood. 2024 Oct 3;144(14):1532-1542.
3. Frietsch JJ, Flossdorf S, Beck JF, Kröger N, Fleischhauer K, Dreger P, Schetelig J, Bornhäuser M, Hochhaus A, Hilgendorf I. Outcomes after allogeneic haematopoietic stem cell transplantation in young adults in Germany. Br J Haematol. 201(2):308-318, 2023
4. Wittwer A, Sponholz K, Frietsch JJ, Linke P, Kropp P, Hochhaus A, Hilgendorf I. Psychosocial distress in young adults surviving hematological malignancies: a pilot study. J Cancer Res Clin Oncol. 149(9):5655-5663, 2023
5. Frietsch JJ, Miethke J, Linke P, Crodel CC, Schnetzke U, Scholl S, Hochhaus A, Hilgendorf I. Treosulfan plus fludarabine versus TEAM as conditioning treatment before autologous stem cell transplantation for B-cell Non-Hodgkin lymphoma. Bone Marrow Transplant. 2022 Jul;57(7):1164-1170. doi: 10.1038/s41409-022-01701-x.
6. Hilgendorf I, Bergelt C, Bokemeyer C, Kaatsch P, Seifart U, Stein A, Langer T. Long-term follow-up of children, adolescents and young adult cancer survivors. Res. Treat. 44(4):184-189. 2021
7. Pulewka K, Strauss B, Hochhaus A, Hilgendorf I. Clinical, social, and psycho-oncological needs of adolescents and young adults (AYA) versus older patients following hematopoietic stem cell transplantation. J Cancer Res Clin Oncol. 147:1239–1246. 2021
8. Frietsch JJ, Hunstig F, Wittke C, Junghanss C, Franiel T, Scholl S, Hochhaus A, Hilgendorf I. Extra-medullary recurrence of myeloid leukemia as myeloid sarcoma after allogeneic stem cell transplantation: impact of conditioning intensity. Bone Marrow Transplant 56(1):101-109. 2021
9. Wolff D, Herzberg PY, Herrmann A, Pavletic SZ, Heussner P, Mumm F, Höfer C, Hilgendorf I, Hemmati PG, Holler E, Greinix H, Mitchell SA. Post-transplant multimorbidity index and quality of life in patients with chronic graft-versus-host disease-results from a joint evaluation of a prospective German multicenter validation trial and a cohort from the National Institutes of Health. Bone Marrow Transplant 56(1):243-256. 2021
10. Salchow J, Mann J, Koch B, von Grundherr J, Jensen W, Elmers S, Straub LA, Vettorazzi E,  Escherich G, Rutkowski S, Dwinger S, Bergelt C, Sokalska-Duhme M, Bielack S, Calaminus G, Baust K, Classen CF, Rössig C, Faber J, Faller H, Hilgendorf I, Gebauer J, Langer T, Metzler M, Schuster S, Niemeyer C, Puzik A, Reinhardt D, Dirksen U, Sander A, Köhler M, Habermann JK, Bokemeyer C, Stein A. Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors – presentation of the CARE for CAYA-Program study protocol and associated literature review Comprehensive assessments and related interventions to enhance the long-term outcomes of child, adolescent and young adult cancer survivors – presentation of the CARE for CAYA-Program study protocol and associated literature review. BMC Cancer. 20(1):16. 2020
11. Schumacher H, Stüwe S, Kropp P, Diedrich D, Freitag S, Greger N, Junghanss C, Freund M, Hilgendorf I. A prospective, randomized evaluation of the feasibility of exergaming on patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant. 53(5):584-90. 2018
12. Pulewka K, Wolff D, Herzberg PY, Greinix H, Heussner P, Mumm FHA, von Harsdorf S, Rieger K, Hemmati P, Hochhaus A, Hilgendorf I. Physical and psychosocial aspects of adolescent and young adults after allogeneic hematopoietic stem-cell transplantation: results from a prospective multicenter trial. J Cancer Res Clin Oncol. 143(8):1613-1619. 2017.

Theses and Dissertations

If you are interested in doing your experimental doctoral dissertation with us, please contact Inken Hilgendorf

Funding

• BMBF
• Deutsche José-Carreras-Leukämie-Stiftung