Hilgendorf Laboratory
PD Dr. Inken Hilgendorf (Group leader)
Klinik für Innere Medizin II
Abteilung Hämatologie und Internistische Onkologie
Universitätsklinikum Jena
Group members
Maria Günther (Lebensmitteltechnologin, Diätassistentin)
Anne Krüger (Dipl.-Psychologin)
Laura Lämmer (Doktorrandin)
Peter Lorenz (Sportwissenschaftler)
Jan Morf (Doktorrand)
Kristin Pulewka (Dipl.-Psychologin)
Andreas Wittwer (Doktorrand)
Research Focus
The treatment of malignant haematological or oncological diseases can contribute to the occurrence of long-term side effects. These long-term consequences often go hand in hand with an impaired quality of life for those affected.
Adolescents and young adults (AYA) are particularly affected because of their young age at the time of illness. Our investigations focus on long-term consequences after tumor therapy or blood stem cell transplantation in young adulthood as well as on the effectiveness of preventive measures (e.g. within the framework of theCARE for CAYA project).
Another focus of interest is immune reconstitution and the therapy of long-term consequences (e.g. chronic GvHD) after allogeneic blood stem cell transplantation.
Publications
2019
• Gebauer J, Hilgendorf I, Koch B-, Langer T. Neue Strukturen in der Betreuung und Nachsorge junger Krebspatienten. Oncol Res Treat. 42(suppl 3):21-26.2019
• Battipaglia G, Labopin M, Kröger N, Vitek A, Afanasyev B, Hilgendorf I, Schetelig J, Ganser A, Blaise D, Itälä-Remes M, Passweg JR, Bonifazi F, Finke J, Ruggeri A, Nagler A, Mohty M. Post-Transplant Cyclophosphamide versus Antithymocyte Globulin in HLA-Mismatched unrelated Donors transplantation. Blood 2019 Jul 3. pii: blood.2019000487. doi: 10.1182/blood.2019000487. [Epub ahead of print]
• Lamby P, Wolff D, Mielke S, Grigoleit GU, Ljungman P, Hilgendorf I, Holler E, Holler B, Weber D, Herr W, Schiltz D, Klein S, Graf S, Bjornhagen-Safwenberg V, Dolderer J, Prantl L. Allogeneic donor split skin grafts for treatment of refractory ulcers in cutaneous chronic Graft-versus-Host Disease after allogeneic hematopoietic stem cell transplantation – a retrospective analysis on 7 patients. Ann Hematol 98(8):1867-1875.2019.
• Wolff D, Hilgendorf I, Wagner-Drouet E, Jedlickova Z, Ayuk F, Zeiser R, Schäfer-Eckart K, Gerbitz A, Stadler M, Klein S, Middeke JM, Lawitschka A, Winkler J, Halter J, Holler E, Kobbe G, Stelljes M, Ditschkowski M, Greinix H. Changes in immunosuppressive treatment of chronic graft-versus-host disease - comparison of 2 surveys within allogeneic hematopoietic stem cell transplant centers in Germany, Austria and Switzerland. Biol Blood Marrow Transplant. 2019 Mar 12. pii: S1083-8791(19)30154-5. doi: 10.1016/j.bbmt.2019.03.003. [Epub ahead of print]
• Brioli A, Klaus M, Sayer H, Scholl S, Ernst T, Hilgendorf I, Scherag A, Yomade O, Schilling K, Hochhaus A, Mügge LO, von Lilienfeld-Toal M. The risk of infections in multiple myeloma before and after the advent of novel agents: a 12-year survey. Ann Hematol. 98(3):713-722. 2019.
• Frietsch JJ, Michel D, Stamminger T, Hunstig F, Birndt S, Schnetzke U, Scholl S, Hochhaus A, Hilgendorf I. In Vivo Emergence of UL56 C325Y Cytomegalovirus Resistance to Letermovir in a Patient with Acute Myeloid Leukemia after Hematopoietic Cell Transplantation. Mediterr J Hematol Infect Dis. 2019 Jan 1;11(1):e2019001. doi: 10.4084/MJHID.2019.001. eCollection 2019.
2018
• Wang L, Ni M, Hückelhoven-Krauss A, Sellner L, Hoffmann JM, Neuber B, Luft T, Hegenbart U, Schönland S, Kleist C, Sill M, Chen B, Wuchter P, Eckstein V, Krüger W, Hilgendorf I, Yerushalmi R, Nagler A, Müller-Tidow C, Ho AD, Dreger P, Schmitt M, Schmitt A. Modulation of B Cells and Homing Marker on NK Cells Through Extracorporeal Photopheresis in Patients With Steroid-Refractory/Resistant Graft-Vs.-Host Disease Without Hampering Anti-viral/Anti-leukemic Effects. Front Immunol. 9: 1-15. 2018
• Kühl R, Meier S, Baeurle M, Wolff D, Lawitschka A, Halter J, Bertz H, Hilgendorf I. Sport- und physiotherapeutische Maßnahmen zur Behandlung der chronischen Graft-versus-Host-Krankheit. Phys Med Rehab Kuror. 28(04): 224-230. 2018
• Mathew NR, Baumgartner F, Braun L, O'Sullivan D, Thomas S, Waterhouse M, Müller TA, Hanke K, Taromi S, Apostolova P, Illert AL, Melchinger W, Duquesne S, Schmitt-Graeff A, Osswald L, Yan KL, Weber A, Tugues S, Spath S, Pfeifer D, Follo M, Claus R, Lübbert M, Rummelt C, Bertz H, Wäsch R, Haag J, Schmidts A, Schultheiss M, Bettinger D, Thimme R, Ullrich E, Tanriver Y, Vuong GL, Arnold R, Hemmati P, Wolf D, Ditschkowski M, Jilg C, Wilhelm K, Leiber C, Gerull S, Halter J, Lengerke C, Pabst T, Schroeder T, Kobbe G, Rösler W, Doostkam S, Meckel S, Stabla K, Metzelder SK, Halbach S, Brummer T, Hu Z, Dengjel J, Hackanson B, Schmid C, Holtick U, Scheid C, Spyridonidis A, Stölzel F, Ordemann R, Müller LP, Sicre-de-Fontbrune F, Ihorst G, Kuball J, Ehlert JE, Feger D, Wagner EM, Cahn JY, Schnell J, Kuchenbauer F, Bunjes D, Chakraverty R, Richardson S, Gill S, Kröger N, Ayuk F, Vago L, Ciceri F, Müller AM, Kondo T, Teshima T, Klaeger S, Kuster B, Kim DDH, Weisdorf D, van der Velden W, Dörfel D, Bethge W, Hilgendorf I, Hochhaus A, Andrieux G, Börries M, Busch H, Magenau J, Reddy P, Labopin M, Antin JH, Henden AS, Hill GR, Kennedy GA, Bar M, Sarma A, McLornan D, Mufti G, Oran B, Rezvani K, Shah O, Negrin RS, Nagler A, Prinz M, Burchert A, Neubauer A, Beelen D, Mackensen A, von Bubnoff N, Herr W, Becher B, Socié G, Caligiuri MA, Ruggiero E, Bonini C, Häcker G, Duyster J, Finke J, Pearce E, Blazar BR, Zeiser R. Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nat Med. 24(3):282-291.2018. Erratum in Nat Med. 24(4):526.2018.
• Schumacher H, Stüwe S, Kropp P, Diedrich D, Freitag S, Greger N, Junghanss C, Freund M, Hilgendorf I. A prospective, randomized evaluation of the feasibility of exergaming on patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant. 53(5):584-90. 2018
• van Gorkom G, van Gelder M, Eikema DJ, Blok HJ, van Lint MT, Koc Y, Ciceri F, Beelen D, Chevallier P, Selleslag D, Blaise D, Foá R, Corradini P, Castagna L, Moreno C, Solano C, Müller LP, Tischer J, Hilgendorf I, Hallek M, Bittenbring J, Theobald M, Schetelig J, Kröger N; CLL subcommittee; Chronic Malignancies Working Party of the EBMT. Outcomes of haploidentical stem cell transplantation for chronic lymphocytic leukemia: a retrospective study on behalf of the chronic malignancies working party of the EBMT. Bone Marrow Transplant. 53(3):255-263.2018.
• Hilgendorf I. Langzeitfolgen und Nachsorge nach Blutstammzelltransplantation. Spectrum Onkologie 7: 32-34. 2018.
2017
• Pulewka K, Wolff D, Herzberg PY, Greinix H, Heussner P, Mumm FHA, von Harsdorf S, Rieger K, Hemmati P, Hochhaus A, Hilgendorf I. Physical and psychosocial aspects of adolescent and young adults after allogeneic hematopoietic stem-cell transplantation: results from a prospective multicenter trial. J Cancer Res Clin Oncol. 143(8):1613-1619. 2017.
• Hilgendorf I, Greinix H, Halter J, Lawitschka A, Wolff D. Vaccination of allogeneic
hematopoietic stem cell transplant recipients-what should be considered? Ann Hematol. 96(4):701-702. 2017.
• Fischer M, Schnetzke U, Spies-Weisshart B, Walther M, Fleischmann M, Hilgendorf I, Hochhaus A, Scholl S. Impact of FLT3-ITD diversity on response to induction chemotherapy in patients with acute myeloid leukemia. Haematologica. 102(4):e129-e131. 2017.
• Fleischmann M, Schnetzke U, Schrenk KG, Schmidt V, Sayer HG, Hilgendorf I, Hochhaus A. Scholl S. Outcome of FLT3-ITD-positive acute myeloid leukemia: impact of allogeneic stem cell transplantation and tyrosine kinase inhibitor treatment. J Cancer Res Clin Oncol. 143(2):337-345. 2017
• Quidde J, Koch B, Salchow J, Jensen W. von Gundherr J, Escherich G, Rutkowski S, Schulz-Kindermann F, Bergelt C, Bokemeyer C, Sokalska-Duhme M, Bielack S, Calaminius G, Classen CF, Rössig C, faber J, Faller H, Hilgendorf I, Langer T, Metzler M, Schuster S, Niemeyer C, Pierce A, Reinhardt D, Sander A, Köhler M, Stein A. Das CARE for CAYA-Programm. Präventionskonzept für junge Menschen nach Krebserkrankung. FORUM 32: 479-484. 2017
2016
• Winkelmann N, Desole M, Hilgendorf I, Ernst T, Sayer HG, Kunert C, Mügge LO, Hochhaus A, Scholl S. Comparison of two dose levels of cyclophosphamide for successful stem cell mobilization in myeloma patients. J Cancer Res Clin Oncol. 142(12):2603-2610. 2016.
• Casalegno-Garduño R, Schmitt A, Spitschak A, Greiner J, Wang L, Hilgendorf I, Hirt C, Ho AD, Freund M, Schmitt M. Immune responses to WT1 in patients with AML or MDS after chemotherapy and allogeneic stem cell transplantation. Int J Cancer. 138(7):1792-801. 2016.
2015
• Hautmann AH, Wolff D, Hilgendorf I, Fehn U, Edinger M, Hoffmann P, Herr W, Kölbl O, Holler B, Sporrer D, Holler E, Hautmann MG. Total nodal irradiation in patients with severe treatment-refractory chronic graft-versus-host disease after allogeneic stem cell transplantation: Response rates and immunomodulatory effects. Radiother Oncol. 116(2):287-93. 2015.
• Richter D, Koehler M, Friedrich M, Hilgendorf I, Mehnert A, Weißflog G. Psychosocial interventions for adolescents and young adult cancer patients: A systematic review and meta-analysis. Crit Rev Oncol Hematol. 95(3):370-86. 2015.
• Geue K, Schmidt R, Nielsen T, Hilgendorf I, Kropp P, Richter D, Sender A, Friedrich M, Brähler E, Stöbel-Richter Y. The extension of the Leipzig questionnaire of motives to have a child (LKM) for use in oncology--test construction and psychometric review. Psychother Psychosom Med Psychol. 65(3-4):119-25. 2015.
• Lorenz K, Rommel K, Mani J, Jin N, Hilgendorf I, Ho AD, Freund M, Schmitt M, Schmitt A. Modulation of lymphocyte subpopulations by extracorporeal photopheresis in patients with acute GvHD or graft rejection. Leuk Lymphoma. 56:671-5. 2015.
• Hilgendorf I, Greinix H, Halter JP, Lawitschka A, Bertz H, Wolff D. Long-term follow up after allogeneic stem cell transplantation. Dtsch Arztebl Int. 112(4): 51-58, 2015
Funding
• G-BA
• Hector-Stiftung