Mid-German Sepsis Cohort

MSC

The Mid-German Sepsis Cohort (MSC) is planned as the world's largest cohort study, which will comprehensively document the functional, cognitive and psychological effects and changes in quality of life after treatment of severe sepsis in the intensive care unit (ICU).

The MSC will have a recruitment period of 3 years and an initially funded follow-up period of one year; a 5 year follow-up is intended. A total of five study centers are involved in the recruitment. Included are patients with severe sepsis / septic shock who have been treated at an ICU and who are at least 18 years at discharge and for which there is a consent form. There are no specific exclusion criteria. Patients will be followed up at regular intervals after discharge from the ICU as long as possible. In addition to general characteristics of patients and their intensive care, functional consequences are a primary interest of the MSC; they are summarized as "activities of daily living" or "instrumental activities of daily living" (e.g. running, dressing, washing). Furthermore, other patient-relevant outcomes such as health-related quality of life, cognitive impairments, post-traumatic stress, anxiety and depression, and neuromuscular deficits, pain, sleep disorders, weight and the resumption of work are assessed. The MSC will also work as a support platform for the participating patients and their families. Ultimately, the generated results will help to develop specific, adapted rehabilitation programs.