Aktuelle Publikationsliste 2012-2023

begutachtete Originalarbeiten:

König C*, Ebersberger A*, Eitner A, Wetzker R, Schaible H-G (2023) Prostaglandin EP3 receptor activation is antinociceptive in sensory neurons via PI3Kγ, AMPK and GRK2. Br J Pharmacol. 2023 Feb;180(4):441-458. doi: 10.1111/bph.15971.

begutachtete Übersichtsartikel:

Buchbeiträge, Monographien & editorials:

begutachtete Originalarbeiten:

• Gimeno-Ferrer F, Eitner A, Bauer R, Lehmenkühler A, Edenhofer ML, Kress M, Schaible H-G, Richter F (2022) From spreading depolarization to epilepsy with neuroinflammation: The role of CGRP in cortex. Exp Neurol. 2022 Jun 26;356:114152. doi: 10.1016/j.expneurol.2022.114152.
• Eitner A, Sparing S, Kohler FC, Müller S, Hofmann GO, Kamradt T, Schaible H-G, Aurich M (2022) Osteoarthritis-Induced Metabolic Alterations of Human Hip Chondrocytes.  Biomedicines. 2022 Jun 8;10(6):1349. doi: 10.3390/biomedicines10061349.

begutachtete Übersichtsartikel:

• Schaible H-G, König C, Ebersberger A (2022) Spinal pain processing in arthritis: Neuron and glia (inter)actions. J Neurochem. 2022 Dec 15. doi: 10.1111/jnc.15742.
• Schaible H-G, Ebersberger A, Natura G, Vazquez E (2022) The role of neuroimmune interactions in musculoskeletal pain. Neuroforum 2022 March 23; https://doi.org/10.1515/nf-2022-0001
• Fischer L, Barop H, Ludin SM, Schaible H-G (2022) Regulation of acute reflectory hyperinflammation in viral and other diseases by means of stellate ganglion block. A conceptual view with a focus on Covid-19. Auton Neurosci. 2022 Jan;237:102903. doi: 10.1016/j.autneu.2021.102903.

Buchbeiträge, Monographien & editorials:

• Radbruch L, Schaible H-G (2022) [War and humanitarian crisis in Ukraine]. Schmerz. 2022 Apr;36(2):79-80. doi: 10.1007/s00482-022-00644-y.

begutachtete Originalarbeiten:

• König C, Vazquez E, Eß S, Ebbinghaus M, Vorpahl B, Ebersberger A, Schaible H-G (2021) Spinal interleukin-1β induces mechanical spinal hyperexcitability in rats: Interactions and redundancies with TNF and IL-6. J Neurochem. 2021 May 29. doi: 10.1111/jnc.15438.
• Eitner A, Müller S, König C, Wilharm A, Raab R, Hofmann GO, Kamradt T, Schaible H-G (2021) Inhibition of Inducible Nitric Oxide Synthase Prevents IL-1β-Induced Mitochondrial Dysfunction in Human Chondrocytes. Int J Mol Sci. 2021 Mar 1;22(5):2477. doi: 10.3390/ijms22052477.

begutachtete Übersichtsartikel:

Buchbeiträge, Monographien & editorials:

• Schaible H-G (2021) [Pain therapy using anti-nerve growth factor antibodies? : Pain research in a dilemma]. Schmerz. 2021 Oct;35(5):301-303. doi: 10.1007/s00482-021-00574-1.
• Schaible H-G, Radbruch L, Jürgens T (2021) [Master of migraine and headache medicine (MMHM) : A newly conceived extraprofessional degree course at Kiel University]. Schmerz 35(3):183-184. doi: 10.1007/s00482-021-00557-2.

begutachtete Originalarbeiten:

• Garza Carbajal A, Ebersberger A, Thiel A, Ferrari L, Acuna J, Brosig S, Isensee J, Moeller K, Siobal M, Rose-John S, Levine J, Schaible H-G, Hucho T (2020) Oncostatin M induces hyperalgesic priming and amplifies signaling of cAMP to ERK by RapGEF2 and PKA. J Neurochem. 2020 Sep 3. doi: 10.1111/jnc.15172.
• Ebbinghaus M, Tuchscherr L, Segond von Banchet G, Liebmann L, Adams V, Gajda M, Hübner CA, Kurth I, Schaible H-G (2020) Gain-of-function mutation in SCN11A causes itch and affects neurogenic inflammation and muscle function in Scn11a+/L799P mice. PLoS One. 2020 Aug 20;15(8):e0237101. doi: 10.1371/journal.pone.0237101. eCollection 2020.
• Eitner A, Culvenor AG, Wirth W, Schaible H-G, Eckstein F (2020) Impact of Diabetes Mellitus on Knee Osteoarthritis Pain and Physical and Mental Status: Data from the Osteoarthritis Initiative. Arthritis Care Res (Hoboken). 2020 Feb 27. doi: 10.1002/acr.24173.
• Leuchtweis J, Segond von Banchet G, Eitner A, Ebbinghaus M, Schaible H-G (2020) Pain-related behaviors associated with persistence of mechanical hyperalgesia post antigen-induced arthritis in rats. Pain. 2020 Feb 27. doi: 10.1097/j.pain.0000000000001852.

begutachtete Übersichtsartikel:

Buchbeiträge, Monographien & editorials:

• Radbruch L, Schaible H-G (2020) [Isolation until it hurts - the consequences of the corona pandemic]. Schmerz. 2020 Aug;34(4):301-302. doi: 10.1007/s00482-020-00484-8
• Radbruch L, Schaible H-G (2020) [COVID-19 and pain-call for papers]. Schmerz. 2020 Apr 24:1-2. doi: 10.1007/s00482-020-00475-9

begutachtete Originalarbeiten:

Richter F, Segond von Banchet G, Schaible H-G (2019) Transient Receptor Potential vanilloid 4 ion channel in C-fibres is involved in mechanonociception of the normal and inflamed joint. Sci Rep. 2019 Jul 29;9(1):10928. doi: 10.1038/s41598-019-47342-x.

Ebbinghaus M, Müller S, Segond von Banchet G, Eitner A, Wank I, Hess A, Hilger I, Kamradt T, Schaible H-G (2019) The contribution of inflammation and bone destruction to pain in arthritis - a study in murine glucose-6-phosphate isomerase (G6PI)-induced arthritis. Arthritis Rheumatol. 2019 Jul 22. doi: 10.1002/art.41051.

Lehmenkühler A, Richter F (2019) Cortical Spreading Depolarization (CSD) Recorded from Intact Skin, from Surface of Dura Mater or Cortex: Comparison with Intracortical Recordings in the Neocortex of Adult Rats. Neurochem Res. 2019 Feb 1. doi: 10.1007/s11064-019-02737-0.

begutachtete Übersichtsartikel:

Buchbeiträge, Monographien & editorials:

begutachtete Originalarbeiten:

Ebbinghaus M, Jenei-Lanzl Z, Segond von Banchet G, Stangl H, Gajda M, Straub RH, Schaible H-G (2018) A Promising New Approach for the Treatment of Inflammatory Pain: Transfer of Stem Cell-Derived Tyrosine Hydroxylase-Positive Cells. Neuroimmunomodulation 2018 Dec 19;25(4):225-237. doi: 10.1159/000495349.

Richter F, Eitner A, Leuchtweis J, Bauer R, Ebersberger A, Lehmenkühler A, Schaible H-G (2018) The potential of substance P to initiate and perpetuate cortical spreading depression (CSD) in rat in vivo. Sci Rep. 2018 Dec 5;8(1):17656. doi: 10.1038/s41598-018-36330-2.

begutachtete Übersichtsartikel:

Ebersberger A (2018) The analgesic potential of cytokine neutralization with biologicals. Eur J Pharmacol. doi: 10.1016/j.ejphar.2018.07.040.

Schaible H-G (2018) Osteoarthritis pain. Recent advances and controversies. Curr Opin Support Palliat Care 12:148-153.

Schaible H-G, Chang HD, Grässel S, Haibel H, Hess A, Kamradt T, Radbruch A, Schett G, Stein C, Straub RH (2018) [Research consortium Neuroimmunology and pain in the research network musculoskeletal diseases]. Z Rheumatol 77:24-30.

Buchbeiträge, Monographien & editorials:

Flor H, Foreman RD, Gebhart GF, Jänig W, Schaible H-G (2018) Obituary Prof. Dr. med. D. Sc. h.c. Robert F. Schmidt, Ph.D. Pain 159: 619-620.

Schaible H-G, Radbruch L (2018) [Obituary for Prof. Dr. med. D. Sc. h.c. Robert F. Schmidt, Ph.D.]. Schmerz 32:15-16.

Schaible H-G, Radbruch L (2018) [A new rubric in Der Schmerz: "PAIN CLINICAL UPDATES"]. Schmerz 32:89.

begutachtete Originalarbeiten:

Ebbinghaus M, Natura G, Segond von Banchet G, Hensellek S, Böttcher M, Hoffmann B, Salah FS, Gajda M, Kamradt T, Schaible H-G (2017) Interleukin-17A is involved in mechanical hyperalgesia but not in the severity of murine antigen-induced arthritis. Sci Rep 7:10334.

Eitner A, Pester J, Vogel F, Marintschev I, Lehmann T, Hofmann GO, Schaible H-G (2017) Pain sensation in human osteoarthritic knee joints is strongly enhanced by diabetes mellitus. Pain 158:1743-1753.

Richter F, Eitner A, Leuchtweis J, Bauer R, Lehmenkühler A, Schaible H-G (2017) Effects of interleukin-1b on cortical spreading depolarization and cerebral vasculature. J Cereb Blood Flow Metab 37:1791-1802.

begutachtete Übersichtsartikel:

Dreier JP et al. (2017) Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group. J Cereb Blood Flow Metab 37:1595-1625.

Eitner A, Hofmann GO, Schaible H-G (2017) Mechanisms of Osteoarthritic Pain. Studies in Humans and Experimental Models. Front Mol Neurosci 10:349.

Hartings JA et al. (2017) The continuum of spreading depolarizations in acute cortical lesion development: Examining Leao's legacy. J Cereb Blood Flow Metab 37:1571-1594.

Richter F (2017) Refresher: Physiologie und Pathophysiologie von Fieber. Zeitschrift für Komplementärmedizin 09:46-51.

Buchbeiträge, Monographien & editorials:

Radbruch L, Schaible H-G (2017) [Too many pain journals and too few reviewers]. Schmerz 31:405-406.

begutachtete Originalarbeiten:

Boettger MK, Ditze G, Bär KJ, Krüdewagen EM, Schaible H-G (2016) Humans, but not animals, perceive the thermal grill illusion as painful. Behav Brain Res 313:172-176.

König C, Morch E, Eitner A, Möller C, Turnquist B, Schaible H-G, Ebersberger A (2016) Involvement of Spinal IL-6 Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-Alpha. J Neurosci 36:9782-9791.

Richter F, Koulen P, Kaja S (2016) N-Palmitoylethanolamine Prevents the Run-down of Amplitudes in Cortical Spreading Depression Possibly Implicating Proinflammatory Cytokine Release. Sci Rep 6:23481.

Salah FS, Ebbinghaus M, Muley VY, Zhou Z, Al-Saadi KR, Pacyna-Gengelbach M, O'Sullivan GA, Betz H, König R, Wang ZQ, Bräuer R, Petersen I (2016) Tumor suppression in mice lacking GABARAP, an Atg8/LC3 family member implicated in autophagy, is associated with alterations in cytokine secretion and cell death. Cell Death Dis 7:e2205.

Segond von Banchet G, König C, Patzer J, Eitner A, Leuchtweis J, Ebbinghaus M, Boettger MK, Schaible H-G (2016) Long-Lasting Activation of the Transcription Factor CREB in Sensory Neurons by Interleukin-1beta During Antigen-Induced Arthritis in Rats: A Mechanism of Persistent Arthritis Pain? Arthritis Rheumatol 68:532-541.

begutachtete Übersichtsartikel:

Buchbeiträge, Monographien & editorials:

Maihöfner C, Gaul C, Kern KU, Schaible H-G, Sommer C (2016) Moderne Praxis der analgetischen Lokaltherapie. UNI-MED Science, UNI-MED-Verlag AG, Bremen, London, Boston

Schaible H-G, Radbruch L (2016) [Tracing the neurobiological causes of chronic pain]. Schmerz 30:125-126.

begutachtete Originalarbeiten:

Ebbinghaus M, Segond von Banchet G, Massier J, Gajda M, Bräuer R, Kress M, Schaible H-G (2015) Interleukin-6-dependent influence of nociceptive sensory neurons on antigen-induced arthritis. Arthritis Res Ther 17:334.

Jochmann E, Boettger MK, Anand P, Schaible H-G (2015) Antigen-induced arthritis in rats is associated with increased growth-associated protein 43-positive intraepidermal nerve fibres remote from the joint. Arthritis Res Ther 17:299.

Massier J, Eitner A, Segond von Banchet G, Schaible H-G (2015) Effects of differently activated rodent macrophages on sensory neurons: implications for arthritis pain. Arthritis Rheumatol 67:2263-2272.

begutachtete Übersichtsartikel:

Azad SC, Pogatzki-Zahn EM, Radbruch L, Schaible H-G (2015) [Pain medicine yesterday, today, tomorrow: 40 years of the Deutsche Schmerzgesellschaft]. Schmerz 29:466-468.

Casser HR, Schaible H-G (2015) [Musculoskeletal pain]. Schmerz 29:486-488, 490-485.

Schaible H-G (2015) Are antagonists at bradykinin 1 receptors promising analgesic drugs? Eur J Pain 19:3-4.

Buchbeiträge, Monographien & editorials:

Schaible H-G (Editor) (2015) Pain Control. Handb Exp Pharmacol 227, Springer Verlag Berlin, Heidelberg

Schaible H-G (2015) Preface. Handb Exp Pharmacol 227:v.

Schaible H-G (2015) Emerging concepts of pain therapy based on neuronal mechanisms. Handb Exp Pharmacol 227:1-14.

Schaible H-G (2015) Scientific basis of pain. In:Rheumatology (sixth edition), edited by Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, Mosby Ltd., Elsevier, pp. 183-187

Vaupel P, Schaible H-G, Mutschler E (2015) Anatomie, Physiologie, Pathophysiologie des Menschen. 7. Auflage, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart

begutachtete Originalarbeiten:

Ebbinghaus M, Gajda M, Holtzman MJ, Schulz S, Schaible H-G (2014) Does chloride channel accessory 3 have a role in arthritis pain? A study on murine antigen-induced arthritis. Neurosci Lett 576:40-44.

König C, Zharsky M, Möller C, Schaible H-G, Ebersberger A (2014) Involvement of peripheral and spinal tumor necrosis factor alpha in spinal cord hyperexcitability during knee joint inflammation in rats. Arthritis Rheumatol 66:599-609.

Leuchtweis J, Boettger MK, Niv F, Redecker C, Schaible H-G (2014) Enhanced neurogenesis in the hippocampal dentate gyrus during antigen-induced arthritis in adult rat--a crucial role of immunization. PLoS One 9:e89258.

Madishetti S, Schneble N, König C, Hirsch E, Schulz S, Müller JP, Wetzker R (2014) PI3Kgamma integrates cAMP and Akt signalling of the mu-opioid receptor. Br J Pharmacol 171:3328-3337.

Richter F, Lütz W, Eitner A, Leuchtweis J, Lehmenkühler A, Schaible H-G (2014) Tumor necrosis factor reduces the amplitude of rat cortical spreading depression in vivo. Ann Neurol 76:43-53.

begutachtete Übersichtsartikel:

Schaible H-G (2014) Nociceptive neurons detect cytokines in arthritis. Arthritis Res Ther 16:470.

Schaible H-G, Straub RH (2014) Function of the sympathetic supply in acute and chronic experimental joint inflammation. Auton Neurosci 182:55-64.

Buchbeiträge, Monographien & editorials :

Radbruch L, Schaible H-G (2014) [Der Schmerz - the leading German-language pain journal]. Schmerz 28:569-570.

Schaible H-G, Richter F (2014) Receptors relevant for joint nociception. In: Musculoskeletal Pain: Basic Mechanisms and Implications. edited by Graven-Nielsen T, Arendt-Nielsen L, IASP Press, Washington DC, pp. 187-204

begutachtete Originalarbeiten:

Boettger MK, Krucker S, Gajda M, Schaible H-G, Hilberg T (2013) Repeated autologous intraarticular blood injections as an animal model for joint pain in haemophilic arthropathy. Arthritis Res Ther 15:R148.

Dietzel F, Boettger MK, Dahlke K, Holzer J, Lehmann F, Gajda M, Bräuer R, Schaible H-G, Kaiser WA, Hilger I (2013) Assessment of rat antigen-induced arthritis and its suppression during glucocorticoid therapy by use of hemicyanine dye probes with different molecular weight in near-infrared fluorescence optical imaging. Invest Radiol 48:729-737.

Eitner A, Pester J, Nietzsche S, Hofmann GO, Schaible H-G (2013) The innervation of synovium of human osteoarthritic joints in comparison with normal rat and sheep synovium. Osteoarthritis Cartilage 21:1383-1391.

Leipold E et al. (2013) A de novo gain-of-function mutation in SCN11A causes loss of pain perception. Nat Genet 45:1399-1404.

Natura G, Bär KJ, Eitner A, Boettger MK, Richter F, Hensellek S, Ebersberger A, Leuchtweis J, Maruyama T, Hofmann GO, Halbhuber KJ, Schaible H-G (2013) Neuronal prostaglandin E2 receptor subtype EP3 mediates antinociception during inflammation. Proc Natl Acad Sci U S A 110:13648-13653.

Segond von Banchet G, Boettger MK, König C, Iwakura Y, Bräuer R, Schaible H-G (2013) Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia. Mol Cell Neurosci 52:152-160.

begutachtete Übersichtsartikel:

Buchbeiträge, Monographien & editorials :

Radbruch L, Schaible H-G (2013) [On the right to have a personal opinion]. Schmerz 27:5-6.

Radbruch L, Schaible H-G (2013) [When the pain is gone then you are dead]. Schmerz 27:452-453.

Schaible H-G (2013) Naturheilverfahren: Grundlagen Möglichkeiten Grenzen, Physiologische Grundlagen. In: Kursbuch Naturheilverfahren, Volger E, Brinkhaus B (Hrsg). Elsevier, Urban und Fischer, München, pp. 37-44.

Schaible H-G (2013) Joint pain: Basic Mechanisms. In Wall and Melzack´s Textbook of Pain, sixth edition, edited by McMahon SB, Tracey I, Koltzenburg M, Turk D, Elsevier Saunders, Philadelphia, PA, pp. 609-619.

Schaible H-G, Bräuer R (2013) Acute and chronic arthritis models. In: Pain Models: Translational Relevance and Applications, edited by HO Handwerker and L Arendt-Nielsen, IASP-Press, Washington DC, pp. 149-162.

Schaible H-G, Straub RH (2013) Pain Neurophysiology. In: Oxford Textbook of Rheumatology, edited by Watts RA, Conaghan PG,  Denton C, Foster H,  Isaacs J, Müller-Ladner U, 4th edition, Oxford University Press, Oxford, UK, pp. 431-436.

begutachtete Originalarbeiten:

Ebbinghaus M, Gajda M, Boettger MK, Schaible H-G, Bräuer R (2012) The anti-inflammatory effects of sympathectomy in murine antigen-induced arthritis are associated with a reduction of Th1 and Th17 responses. Ann Rheum Dis 71:253-261.

Ebbinghaus M, Uhlig B, Richter F, von Banchet GS, Gajda M, Bräuer R, Schaible H-G (2012) The role of interleukin-1beta in arthritic pain: main involvement in thermal, but not mechanical, hyperalgesia in rat antigen-induced arthritis. Arthritis Rheum 64:3897-3907.

Richter F, Bauer R, Ebersberger A, Lehmenkühler A, Schaible H-G (2012) Enhanced neuronal excitability in adult rat brainstem causes widespread repetitive brainstem depolarizations with cardiovascular consequences. J Cereb Blood Flow Metab 32:1535-1545.

Richter F, Natura G, Ebbinghaus M, von Banchet GS, Hensellek S, König C, Bräuer R, Schaible H-G (2012) Interleukin-17 sensitizes joint nociceptors to mechanical stimuli and contributes to arthritic pain through neuronal interleukin-17 receptors in rodents. Arthritis Rheum 64:4125-4134.

Vazquez E, Kahlenbach J, Segond von Banchet G, König C, Schaible H-G, Ebersberger A (2012) Spinal interleukin-6 is an amplifier of arthritic pain in the rat. Arthritis Rheum 64:2233-2242.

begutachtete Übersichtsartikel:

Schaible H-G (2012) [Neuroimmune connections in inflammation and pain. ImmunoPain]. Z Rheumatol 71:698-700.

Schaible H-G (2012) Mechanisms of chronic pain in osteoarthritis. Curr Rheumatol Rep 14:549-556.

Buchbeiträge, Monographien & editorials :

Schaible H-G (2012) Anatomische, physiologische und pathophysiologische Grundlagen des Schmerzes. In: Chronische Schmerzen in der Praxis - Fragen und Antworten, von Sprott H, Maurer K (Hrsg.), Uni-Med, Bremen, London, Boston, pp. 26-33.

Schaible H-G (2012) Physiologie. In: Schmerzmedizin, von Bernateck M, Karst M, Sabatowski R, Siebrecht D (Hrsg.), Thieme, Stuttgart, New York, pp. 21-27