Original papers in peer reviewed journals
Hermes M, Antonow-Schlorke I, Hollstein D, Kühn S, Rakers F, Frauendorf V, Dreiling M, Rupprecht S, Schubert H, Witte OW, Schwab M (2020). Maternal psychosocial stress during early gestation impairs fetal structural brain development in sheep. Stress 23(2):233-242.
Schwab M, Witte OW. Prenatal stress and brain disorders in later life. (2020). Neurosci Biobehav Rev. 2020 Jun 16:S0149-7634(20)30429-2. doi: 10.1016/j.neubiorev.2020.06.002.
Franke K, Bublak P, Hoyer D, Billiet T, Gaser C, Witte OW, Schwab, M (2020). In vivo biomarkers of structural and functional brain development and ageing. Neurosci Biobehav Rev in press.
Franke K, Van den Bergh BRH, Rakers F, Kroegel N, de Rooij SR, Roseboom TJ, Witte OW, Nathanielsz, PW Schwab, M (2020). Effects of Malnutrition and Maternal Stress during Pregnancy on Offspring Brain Structure in Humans. Neurosci Biobehav Rev 2020 Jan 28:S0149-7634(17)30748-0. doi: 10.1016/j.neubiorev.2020.01.031.
Müller JJ, Antonow-Schlorke I, Kroegel N, Rupprecht S, Rakers F, Witte OW, Schwab M (2018). Cardiovascular effects of prenatal stress – Are there implications for cerebrovascular, cognitive and mental health outcome? Neurosci Biobehav Rev in press.
Van den Bergh B.R.H., van den Heuvel MI., Lahti M., Braeken M., de Rooij S.R., Entringer S., Hoyer D., Roseboom T., Räikkönen K., King S., Schwab M. (2018). Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy. Neurosci Biobehav Rev Jul 28. pii: S0149-7634(16)30734-5. [Epub ahead of print].
Rakers F, Rupprecht S, Dreiling M, Bergmeier C, Witte OW, Schwab M (2017). Transfer of maternal psychosocial stress to the fetus. Neurosci Biobehav Rev doi: 10.1016/j.neubiorev.2017.02.019. [Epub ahead of print].
Sahm A, Bens M, Henning Y, Vole C, Groth M, Schwab M, Platzer M, Szafranski K, Dammann P (2018). Higher transcriptome 1 stability during 2 aging in long-lived giant mole-rats 3 compared to short-lived rats. Aging-US 10(12):3938-56.
Schiffner R, Bischoff S, Schubert H, Rakers F, Rupprecht S, Maziolis G, Huber O, Lemke C, Rupprecht S (2018). Schwab M, Lehmann T, Schmidt M. Underlying mechanism of subcortical brain protection during hypoxia and reoxygenation in a sheep model - influence of α1-adrenergic signaling. PLoS one 13(5):e0196363.
Sahm A, Bens M, Szafranski K, Holtze S, Groth M, Görlach M, Calkhoven C, Müller C, Kaether C, Schwab M, Cellerino A, Hildebrandt T, Burda H, Dammann P, Platzer M. (2018). Long-lived rodents reveal signatures of positive selection in genes associated with lifespan and eusociality. PLoS Genet 14(3):e1007272.
Dreiling M, Schiffner R, Bischoff S, Rupprecht S, Kroegel N, Schubert H, Witte OW, Schwab M, Rakers F (2018). Impact of chronic maternal stress during early gestation on maternal-fetal stress transfer and fetal stress sensitivity in sheep. Stress 21 (1):1-10.
Franke K, Gaser C, Roseboom TJ, Schwab M, de Rooij SR (2017). Premature brain aging in humans exposed to maternal nutrient restriction during early gestation. Neuroimage 173:460-71.
Franke K, Clarke GD, Dahnke R, Gaser C, Kuo AH, Li C, Schwab M, Nathanielsz PW (2017). Premature brain aging in baboons resulting from moderate fetal undernutrition. Front Aging Neurosci 9:92.
Agba OB, Lausser L, Huse K, Bergmeier C, Jahn N, Groth M, Bens M, Gall M, Witte OW, Kestler H, Schwab M, Platzer M (2017). Tissue-, sex- and age-specific DNA methylation of rat glucocorticoid receptor gene promoter and insulin like growth factor 2 imprinting control region. Physiol Genomics 49(11):690-702.
Kuo AH, Li C, Huber HF, Schwab M, Nathanielsz PW, Clarke GD (2017). Maternal nutrient restriction during pregnancy and lactation leads to impaired right ventricular function in young adult baboons. J Physiol 595(13):4245-4260.
Kuo AH, Li J, Li C, Huber H, Schwab M, Nathanielsz PW, Clarke G (2017). Prenatal steroid administration leads to adult pericardial and hepatic steatosis in male baboons. Int J Obesity (Lond). 2017 Aug;41(8):1299-1302.
Müller JJ, Schwab M Rosenfeld CR, Antonow-Schlorke I, Nathanielsz PW, Rakers F, Schubert, H, Witte OW, Rupprecht S (2017). Fetal sheep mesenteric resistance arteries in sheep: functional and structural maturation. J Vasc Res 54(5):259-271.
Schiffner R, Rodríguez-González GL, Rakers F, Nistor M, Nathanielsz PW, Daneva T, Schwab M, Lehmann T, Schmidt M (2017). Effects of late gestational fetal exposure to dexamethasone administration on the postnatal hypothalamus-pituitary-adrenal axis response to hypoglycemia in pigs. Int J Mol Sci 18(11). pii: E2241.
Schiffner R., Bischoff S.J., Lehmann T., Rakers F., Rupprecht S., Reiche J., Matziolis G., Schubert H., Schwab M., Huber O., Schmidt M (2017). Redistribution of cerebral blood flow during severe hypovolemia and reperfusion in a sheep model: critical role of α1-adrenergic signaling. Int J Mol Sci 18(5). pii: E1031.
Anegroaie P, Frasch MG, Rupprecht S, Antonow-Schlorke I, Müller T, Schubert H, Witte OW, Schwab M (2017). Development of somatosensory-evoked potentials in foetal sheep: effects of betamethasone. Acta Physiol (Oxf) 220(1):137-49.
Bischoff SJ, Schmidt M, Lehmann T, Irintchev A, Schubert H, Jung C, Schwab M, Huber O, Matziolis G, Schiffner R (2016). Increase of cortical cerebral blood flow and further cerebral microcirculatory effects of Serelaxin in a sheep model. Am J Physiol Heart Circ Physiol 311(3):H613-20.
de Rooij SR, Caan MW, Swaab DF, Nederveen AJ, Majoie CB, Schwab M, Painter RC, Roseboom TJ (2016). Prenatal famine exposure has sex-specific effects on brain size. Brain 139(Pt 8):2136-42.
Dreiling M, Bischoff S, Schiffner R, Rupprecht S, Kiehntopf M, Schubert H, Witte OW, Nathanielsz PW, Schwab M, Rakers F (2016). Stress-induced decrease of uterine blood flow in sheep is mediated by alpha 1-adrenergic receptors. Stress 19 (5):547-51.
Rakers, F, Schiffner, R, Brandstädt, A, Rupprecht, S, Witte, OW, Schlattmann, P, Schwab, M (2016). Rapid weather changes are associated with increased ischemic stroke risk: a case-crossover study. Eur J Epidemiol 31(2), 137-146.
Bischoff SJ, Schmidt M, Lehmann T, Schwab M, Matziolis G, Saemann A, Schiffner R (2015). Renal glucose release during hypoglycemia is partly controlled by sympathetic nerves - a study in pigs with unilateral surgically denervated kidneys. Physiol Rep 3(11):pii: e12603.
de Rooij, SR, van Pelt AAM, Ozanne SE, Korver CM, van Daalen SK, Painter RC, Schwab M, Viegas MH:, Roseboom TJ (2015). Prenatal undernutrition and leukocyte telomere length in late adulthood: the Dutch famine birth cohort study. Am J Clin Nutr 102(3):655-60.
Rakers F, Bischoff S, Schiffner, R, Haase M, Rupprecht S Kiehntopf M, Kühn-Velten WN, Schubert H, Witte OW, Nijland MJ, Nathanielsz PW, Schwab, M (2015). Role of Catecholamines in Maternal-Fetal Stress Transfer in Sheep Fetus. Am J Obstet Gynecol 213(5):684.e1-9.
Xie L, Antonow-Schlorke I, Schwab M, McDonald, TJ, Nathanielsz PW (2013). The frontal cortex IGF system is down regulated in the term, intrauterine growth restricted fetal baboon. Growth Horm IGF Res 23(5):187-92.
Rakers F, Frauendorf V, Rupprecht S, Schiffner R, Bischoff S, Kientopf, M, Reinhold P, Witte OW, Schubert H, Schwab, M (2013). Effects of early and late-gestational maternal stress and synthetic glucocorticoids on development of the fetal hypothalamic–pituitary–adrenal axis in sheep. Stress 16:122-9.
Schwab M, Coksaygan T, Rakers F, Nathanielsz PW (2012). Glucocorticoid exposure of sheep at 0.7 to 0.75 gestation augments late gestation fetal stress responses. Am J Obstet Gynecol 206(3):253.e16-22.
Antonow-Schlorke I1, Schwab M1, Cox LA, Li C, Stuchlik K, Witte OW, Nathanielsz PW, McDonald TJ (2011). Vulnerability of the fetal primate brain to moderate reduction in maternal global nutrient availability. PNAS 108(7):3011-6 (1authors contributed equally to the paper).
Schneider U, Arnscheidt C, Schwab M, Haueisen J, Seewald, HJ Schleussner, E (2010). Steroids that induce lung maturation acutely affect higher cortical function: a fetal magnetoencephalography study. Reprod Sci 18(1):99-106
Löhle M, Schwab M, Kadner S, Ford S, Nijland M, Lawrence P, Gilbert J, Brenna T, Nathanielsz PW (2009). Dose response effects of betamethasone on maturation of the fetal sheep fetal lung. Am J Obstet Gynecol 202(2):186.e1-7.
Frasch MG, Müller T, Szynkaruk M, Schwab M (2009). Validation of spontaneous assessment of baroreceptor reflex sensitivity and its relation to heart rate variability in the ovine fetus pre- and near-term. Can J Physiol Pharmacol l87(9):736-42.
Schwab K, Groh T, Schwab M, Witte H (2009). Nonlinear analysis and modeling of cortical activation and deactivation patterns in the immature fetal electrocorticogram. Chaos 19(1):015111.
Frasch MG, Müller T, Hoyer D, Weiss C, W Schubert H, Schwab M (2009). Nonlinear properties of vagal and sympathetic modulations of heart rate variability in ovine fetus near term. Am J Physiol 296(3):R702-7.
Frasch MG, Müller T, Wicher C, Weiss C, W Schwab K, Schubert H, Schwab M (2009). Heart rate variability analysis allows early asphyxia detection in ovine fetus. Reprod Sci 16(5):509-17.
Antonow-Schlorke I, Helgert A, Gey C, Coksaygen T, Schubert H, Nathanielsz PW, Witte OW, Schwab M (2009). Adverse effects of antenatal glucocorticoids on cerebral myelination in sheep are dose dependent and specific to the fetal stage of development. Obstet Gynecol 113(1):142-151.
Raschke C, Schmidt S, Schwab M, Jirikowski G (2008). Effects of betamethasone treatment on central myelination in fetal sheep: an electron microscopical study. Anat Histol Embryol 37:95-100.
McCallum J, Smith N, Schwab M, Nathanielsz PW, Coksaygan T, Reinhardt B, Richardson B (2008). Effects of antenatal glucocorticoids on cerebral substrate metabolism in the pre-term ovine fetus. Am J Obstet Gynecol 198:105.e1-9.
McCallum J, Smith N, MacLachlan JN, Coksaygan T, Schwab M, Nathanielsz PW, Richardson B (2008). Effects of antenatal glucocorticoids on cerebral protein synthesis in the pre-term ovine fetus. Am J Obstet Gynecol 198:103.e1-6.
Antonow-Schlorke I, Müller T, Brodhun M, Wicher C, Schubert H, Nathanielsz PW, Witte OW, Schwab M (2007). Betamethasone related acute alterations of microtubule associated proteins in the fetal sheep brain are reversible and independent of age during the last third of gestation. Am J Obstet Gynecol 196:553.e1-6. (“Editors choice”)
Frasch MG, Müller T, Wicher C, Weiss C, W Löhle M, Schwab K, Schubert H, Nathanielsz, PW, Witte OW, Schwab M (2007). Fetal body weight and the development of the control of the cardiovascular system in fetal sheep. J Physiol (Lond) 579:893-907
Antonow-Schlorke I, Ebert M, Cun L, Gschanes A, Witte OW, Nathanielsz PW, Schwab M (2007). Effects of antenatal glucocorticoid therapy on glucose transporter proteins in the fetal baboon brain. J Med Primatol 36:17-20.
Frank B, Frasch MG, Schneider U, Roedel M, Schwab M, Hoyer D. (2006) Complexity of heart rate fluctuations in near-term sheep and human fetuses during sleep. Biomed Tech (Berl). 51:233-6.
Schwab M, Coksaygan T, Samtani M, Jusko WJ, Nathanielsz PW (2006). Kinetics of betamethasone and fetal cardiovascular adverse effects in pregnant sheep after different doses. Obstet Gynecol 108:617-25.
Antonow-Schlorke I, Ebert M, Müller T, Coksaygan T, Schubert H, Gschanes A, Witte OW, Nathanielsz PW, Schwab M (2006). Glucocorticoid effects on glucose transporter proteins in the fetal sheep brain. Neurosci Lett 403(3):261-265.
Schwab M, Coksaygan T, Nathanielsz PW (2006). Betamethasone effects on ovine uterine and umbilical placental perfusion at the dose used to enhance fetal lung maturation. Am J Obstet Gynecol 194:572-579.
Löhle M, Müller T, Wicher C, Roedel M, Schubert H, Nathanielsz PW, Witte OW, Schwab M (2005). Betamethasone effects on fetal sheep cerebral blood flow are not dependent on maturation of cerebrovascular system and pituitary-adrenal axis. J Physiol (Lond) 564:575-588.
Samtani MN, Schwab M, Nathanielsz PW, Jusko WJ (2004). Area/moment and compartmental modeling of pharmacokinetics during pregnancy: applications to maternal/fetal exposures to corticosteroids in sheep and rats. Pharm Res 21:2279-2292.
Colberg C, Antonow-Schlorke I, Müller T, Schubert H, Nathanielsz PW, Witte OW, Schwab M (2004). Recovery of glucocorticoid-related loss of synaptic density in the fetal sheep brain at 0.75 of gestation. Neurosci Lett 364:130-134.
Samtani MN, Schwab M, Nathanielsz PW, Jusko WJ (2004). Stabilization and HPLC analysis of betamethasone sodium phosphate in plasma. J Pharm Sci 93: 726-732.
Antonow-Schlorke I, Schwab M, Li C, Nathanielsz PW (2003). Glucocorticoid exposure at the dose used clinically alters cytoskeletal proteins and presynaptic terminals in the fetal baboon brain. J Physiol (Lond) 547: 117-123. (Artikel erhielt Titelblatt des Journals).
Müller T, Schubert H, Schwab M (2003). Early prediction of fetal numbers in sheep based on peripheral plasma progesterone concentrations and season of the year. Vet Rec 152:137-8.
Müller T, Löhle M, Schubert H, Wicher C, Antonow-Schlorke I, Sliwka U, Nathanielsz PW, Schwab M (2002). Developmental changes in cerebral autoregulatory capacity in the fetal sheep parietal cortex. J Physiol (Lond) 539: 957-67.
Schwab M, Rödel M, Schmidt K, Müller T, Schubert H, Anwar M A, Nathanielsz PW (2001). Nonlinear changes of electrocortical activity after antenatal betamethasone treatment in fetal sheep. J Physiol (Lond) 531: 535-543.
Schwab M, Antonow-Schlorke I, Kühn B, Müller T, Schubert H, Walter B, Sliwka U, Nathanielsz PW (2001). Effect of antenatal betamethasone treatment on microtubule associated proteins MAP1B and MAP2 in fetal sheep. J Physiol (Lond) 530: 497-506. (Artikel erhielt Titelblatt des Journals).
Antonow-Schlorke I, Kühn B, Müller T, Schubert H, Sliwka U, Nathanielsz P W, Schwab M (2001). Antenatal betamethasone treatment reduces synaptophysin in presynaptic terminals in the fetal sheep brain. Neurosci Lett 297: 147-150.
Schwab M, Rödel M, Anwar M A, Buchwalder LF, Müller T, Schubert H, Walter B, Nathanielsz PW (2000). Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol (Lond) 528: 619-632.
Schmidt K, Kott M, Müller T, Schubert H, Schwab M (2000). Developmental changes in the complexity of the electrocortical activity in fetal sheep. J Physiol (Paris) 94: 435-443.
Schwab M, Schmidt K, Witte H, Abrams RM (2000). Investigation of nonlinear ECoG changes during spontaneous sleep state changes and cortical arousal in fetal sheep. Cereb Cortex 10: 142-148.
Schmidt K, Schwab M, Abrams RM, Witte H (1999). Nonlinear analysis of the fetal ECoG: predictability and bispectral measures. Theor Biosci 118: 219-230.
Witte H, Breidbach O, Schmidt K, Schwab M (1999). News and views in signal analysis of the electröncephalogram (EEG). Theor Biosci 118: 284-299.
Anwar MA, Schwab M, Poston L, Nathanielsz PW (1999). Betamethasone mediated vascular dysfunction and changes in hematological profile in the ovine fetus. Am J Physiol 276: H1137-1143.
Schwab M, Antonow-Schlorke I, Zwiener U, Bauer R (1998). Brain derived peptides reduce the size of cerebral infarction and loss of MAP2 after focal ischemia in rats. J Neural Transmiss Suppl. 53: 299-311.
Antonelli P, Abrams RM, Gerhardt KJ, Schwab M, Bauer R (1998). Vestibular function of the fetal sheep. Otolaryngol Head Neck Surg 118: 571-575.
Abrams RM, Schwab M, Gerhardt KJ, Bauer R, Antonelli P (1998). Caloric stimulation of the inner ear in fetal sheep: Effect on eye movements and electrocorticogram. Int J Ped Otorhinolaryngol 45: 59-68.
Schwab M, Bauer R, Zwiener U (1998). Mild hypothermia prevents the occurrence of cytotoxic brain edema in rats. Acta Neurobiol Exp 58: 29-35.
Schwab M, Bauer R, Zwiener U (1997). The distribution of normal brain water content in wistar rats and its increase due to ischemia. Brain Res 749: 82-87.
Schwab M, Schaller R, Bauer R, Zwiener U (1997). Morphofunctional effects of permanent bilateral carotid occlusion and short-term hypoxia in rats. Exp Tox Pathol 49: 29-37.
Schwab M, Bauer R, Zwiener U (1997). Physiological effects and brain protection by hypothermia and Cerebrolysin after permanent bilateral carotid artery clamping in rats. Exp Tox Pathol 49: 105-116.
Bauer R, Schwab M, Abrams RM, Stein J, Gerhardt KJ (1997). Electrocortical and heart rate response during vibroacoustic stimulation in fetal sheep. Am J Obstet Gynecol 177: 66-71.
Schwab M, Antonow-Schlorke I, Dürer U, Bauer R (1996). Effects of Cerebrolysin on cytoskeletal proteins after focal ischemia in rats. J Neural Transmission Suppl 47: 279.
Abrams RM, Schwab M, Gerhardt KJ, Bauer R, Peters AJM (1996). Vibroacoustic stimulation with a complex signal: Effect on behavioral state in fetal sheep. Biol Neonate 70: 155-164