Unsere zunehmend alternde Bevölkerung erfordert neue medizinische Ansätze im kompletten Gesundheitssystem. Ziel unseres Forschungsschwerpunktes ist die Entschlüsselung allgemeiner altersassoziierter Mechanismen, die zur neuronalen Erhaltung, der Zellreparatur und der Hirnplastizität beitragen. Durch die Aufklärung der Ursachen von Schmerz und Entzündungen sollen neue Behandlungsansätze gegen chronische Erkrankungen gefunden werden.
Research groups at JUH, or alliances JUH scientists are involved in:
Jena Center of Healthy Aging The center brings together clinician scientics from various disciplines to focus on the topic of ageing, to introduce new treatment strategies in age and age-related diseases, and to discuss clinically relevant issues on the subject.
GRK 2155 ProMoAge The aim of the Research Training Group is to investigate posttranslational modifications (PTMs) of cellular proteins as key players in age progression. Scientists from the universities of Halle and Jena as well as from the Leibniz Institute of Age Research Jena combine their expertise from various fields of chemistry, biochemistry, molecular biology, cell biology, biomedicine and “omics”-based technologies to characterise PTM-mediated mechanisms of functional decline during ageing.
Visual functions are known to be particularly prone to normal aging processes and also to beginning Alzheimer-type neurodegeneration. In healthy observers, certain components of visuo-attentional functioning, including perceptual processing speed and top-down control, are influenced by preparation and expectancy effects. The aim of the proposed project is to examine how normal and pathological aging modulate such active perception effects on processing speed and top-down control of attention. Furthermore, we plan to assess how resting state brain network connectivity changes mediate these age effects.
DFG Clinician Scientist-Program OrganAge Age-associated changes predispose for diseases. It is the aim of the present program to explore ageing mechanisms as e.g. stem cell ageing, immune ageing, autophagy, epigenetic and metabolic pathways as targets for the development of therapeutic interventions. This approach inherently requires an interdisciplinary interaction of specialists from different medical fields, e.g. internal medicine, surgery, neurology and others. Simultaneously, the program is part of an enduring structure enabling career pathways for clinician scientists.
The group brings together clinician scientists in the field of antibody-mediated immunological disorders with basic scientists in the field of neurophysiology, molecular neurobiology, and neuroimmunology collectively investigating autoantibody-mediated pathology in the CNS.
ITN SmartAge The EU-funded SmartAge project aims to train a new generation of scientists to understand the role of the microbiome-gut-brain axis in aging and its impact on cognition. The project will apply a translational approach combining animal and human studies, nutritional and lifestyle interventions, cognitive testing, brain imaging, omics and systems biology to find regulators of gut-brain communication.