Principal investigator: Dr. Stefanie Deinhardt-Emmer
BMBF (Infectognostics) 2020 - 2025
Projektleiterin: Prof. Dr. Britta Qualmann
DFG 2020-2020
The joint project with BLINK AG, IPHT, HKI and FLI aims to establish a test format to detect S. aureus and its resistance and virulence factors in both human and veterinary medicine. In addition, this project will address the important aspects of cytotoxicity, invasion and immune response, as the course of disease is strongly linked to the immunological responses of infection.
Principal investigator: Prof. Dr. Christina Ehrhardt
BMBF 2020 -2021
So far, little information is available about SARS-CoV-2-induced cellular mechanisms, especially in context with therapeutic treatment. As part of this project, we focus on the side effects of frequently used pharmaceutical substances during the infection of SARS-CoV-2 in vitro. Furthermore, SARS-CoV-2-mediated effects on the innate immune response, barrier integrity and the regulation of hemostasis are investigated by use of simple and complex cell culture systems.
Principal investigators: Prof. Dr. Bettina Löffler und PD Dr. Lorena Tuchscherr
BMBF 2020 - 2023
In this project, we investigate the mesenchymal mechanisms and dietary targeting of inflammatory bone loss caused by bacterial colonization and infection. For this proposal, cell culture and animal experiments will be performed to investigate the host-pathogen interaction that leads to bone loss.
Principal investigator: PD Dr. Lorena Tuchscherr
BMWi (ZIM) 2020 - 2023
In this project, we will develop single-cell analysis (scRNaseq) to investigate the host-pathogen interaction within host cells. scRNaseq offers stable long-read NGS from host and bacteria during the process of infection to determinate the specific host signals which enhance/trigger the intracellular persistence The project is performed in collaboration with Jena Bioscience and ArgenTag.