Molecular Cardiology and Stem Cell Research
Leiter: Prof. Dr. Maria Wartenberg
Mitabeiter: Erik Mühlbrandt, Jessica Hoff, Stephanie Leißner, Antje Wyrwa, Johanna Schönleben, Stephan Latz
Inhalt:
Der Fokus dieses Forschungsprojekts liegt bei der Erforschung der Signalprozesse, welche die kardiovaskulären Differenzierung embrionaler und erwachsener Stammzellen kontrollieren. Wir untersuchen welche Mikroumgebung (reaktive O2-Spezien, Hypoxie, Metabolismen, Membranpotentiale) und welche Signalketten (PI3-Kinase Signalisierung, AMPK Signalisierung) die Plastizität kontrollieren oder eine Stammzelle dazu anregen sich in eine funktionale Kardiomyozyte oder Endothelzelle zu transformieren.
Relevante Publikationen:
NADPH oxidase and eNOS control cardiomyogenesis in mouse embryonic stem cells on ascorbic acid treatment
Bartsch C, Bekhite MM, Wolheim A, Richter M, Ruhe C, Wissuwa B, Marciniak A, Müller J, Heller R, Figulla HR, Sauer H, Wartenberg M.
Free Radic Biol Med. 2011 Jul 15;51(2):432-43
VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells
Bekhite MM, Finkensieper A, Binas S, Müller J, Wetzker R, Figulla HR, Sauer H, Wartenberg M.
J Cell Sci. 2011 Jun 1;124(Pt 11):1819-30
Stimulation of cardiomyogenesis of embryonic stem cells by nitric oxide downstream of AMP-activated protein kinase and mTOR signaling pathways
Padmasekar M, Sharifpanah F, Finkensieper A, Wartenberg M, Sauer H.
Stem Cells Dev. 2011 Dec;20(12):2163-75
Antibacterial capacity of differentiated murine embryonic stem cells during defined in vitro inflammatory conditions
Finkensieper A, Bekhite MM, Fischer H, Nitza S, Figulla HR, Müller JP, Sauer H, Wartenberg M.
Stem Cells Dev. 2013 Jul 15;22(14):1977-90
Hypoxia, leptin, and vascular endothelial growth factor stimulate vascular endothelial cell differentiation of human adipose tissue-derived stem cells
Bekhite MM, Finkensieper A, Rebhan J, Huse S, Schultze-Mosgau S, Figulla HR, Sauer H, Wartenberg M.
Stem Cells Dev. 2014 Feb 15;23(4):333-51
NOS inhibition synchronizes calcium oscillations in human adipose tissue-derived mesenchymal stem cells by increasing gap-junctional coupling
Sauer H, Sharifpanah F, Hatry M, Steffen P, Bartsch C, Heller R, Padmasekar M, Howaldt HP, Bein G, Wartenberg M.; J Cell Physiol. 2011 Jun;226(6):1642-50
Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism
Sharifpanah F, Wartenberg M, Hannig M, Piper HM, Sauer H.
Stem Cells. 2008 Jan;26(1):64-71. Epub 2007 Oct 18
Control of leucocyte differentiation from embryonic stem cells upon vasculogenesis and confrontation with tumour tissue
Hannig M, Figulla HR, Sauer H, Wartenberg M.
J Cell Mol Med. 2010 Jan;14(1-2):303-12
Static magnetic fields increase cardiomyocyte differentiation of Flk-1+ cells derived from mouse embryonic stem cells via Ca2+ influx and ROS production
Bekhite MM, Figulla HR, Sauer H, Wartenberg M.
Int J Cardiol. 2013 Aug 10;167(3):798-808
Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men
Müller M, Stockmann M, Malan D, Wolheim A, Tischendorf M, Linta L, Katz SF, Lin Q, Latz S, Brunner C, Wobus AM, Zenke M, Wartenberg M, Boeckers TM, von Wichert G, Fleischmann BK, Liebau S, Kleger A.
Stem Cell Rev. 2012 Sep;8(3):720-40
Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells
Kleger A, Seufferlein T, Malan D, Tischendorf M, Storch A, Wolheim A, Latz S, Protze S, Porzner M, Proepper C, Brunner C, Katz SF, Varma Pusapati G, Bullinger L, Franz WM, Koehntop R, Giehl K, Spyrantis A, Wittekindt O, Lin Q, Zenke M, Fleischmann BK, Wartenberg M, Wobus AM, Boeckers TM, Liebau S.
Circulation. 2010 Nov 2;122(18):1823-36