Our research team is interested in the following topics:
Monocyte-mediated immune responses in experimental stroke models and regulation of interneuron migration by CXCR4 and CXCR7.
|Dr. rer. nat. Dagmar Schütz, scientist||93 25 681|
|Christine Anders, technician||93 25 694, 93 25 687|
|Heike Stadler, technician||93 25 694, 93 25 687|
DFG: Modulation of neuroprotective PI3-kinase/Akt signal transduction via sst2 somatostatin receptors.
DFG: Role of chemokine SDF-1 in reward-coupled neurogenesis in the hippocampus.
DFG: CXCL12-dependent development of neuronal structures under the influence of the atypical chemokine receptor CXCR7.
Doktor Robert Pfleger Stiftung: Structural determinants of atypical functions in the CXCR7 chemokine receptor.
- Nakai A, Fujimoto J, Miyata H, Stumm R, Narazaki M, Schulz S, Baba Y, Kumanogoh A, Suzuki K: The COMMD3/8 complex determines GRK6 specificity for chemoattractant receptors. J Exp Med. 2019 May 14. pii: jem.20181494
- Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar, P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R.; ACKR3 Regulation of neuronal migration requires ACKR3 phosphorylation, but not β-Arrestin. Cell Rep. 26(6):1473-1488.e9, 2019
- Abe P, Wüst HM, Arnold SJ, van de Pavert SA, Stumm R.: CXCL12-mediated feedback from granule neurons regulates generation and positioning of new neurons in the dentate gyrus. Glia. 2018; 66:1566-1576
- Luo J, Busillo JM, Stumm R, Benovic JL: G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of β-Arrestin. Mol Pharmacol. 2017 Jun;91(6):554-566
- Drube S, Kraft F, Dudeck J, Müller AL, Weber F, Göpfert C2, Meininger I, Beyer M, Irmler I2, Häfner N, Schütz D, Stumm R, Yakovleva T, Gaestel M, Dudeck A3, Kamradt T.: MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation. J Immunol. 2016 Nov 1;197(9):3662-3668
For long-term microscopy of cell cultures, the institute operates an IncuCyte microscope in cooperation with research teams from the Institute of Neurology, the Clinic for Inner Medicine II, and the department of Human Genetics. Focus is on the observation of neurons and non-neuronal cells under chemokine treatment. (Funded by: European Fonds for Regional Development)