RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells. Narasimhan H, Richter ML, Shakiba R, Papaioannou NE, Stehle C, Ravi Rengarajan K, Ulmert I, Kendirli A, de la Rosa C, Kuo PY, Altman A, Münch P, Mahboubi S, Küntzel V, Sayed A, Stange EL, Pes J, Ulezko Antonova A, Pereira CF, Klein L, Dudziak D, Colonna M, Torow N, Hornef MW, Clausen BE, Kerschensteiner M, Lahl K, Romagnani C, Colomé-Tatché M, Schraml BU. Proc Natl Acad Sci U S A. 2025 Mar 4;122(9):e2417308122. doi: 10.1073/pnas.2417308122. Epub 2025 Feb 24. PMID: 39993193.

Avelumab mediates antibody-dependent cellular cytotoxicity against monocyte-derived dendritic cells through natural killer cells. Sauerer T, Bremm F, Beenen AC, Heger L, Dudziak D, Bosch NC, Erdmann M, Berking C, Schaft N, Dörrie J. MedComm (2020). 2025 Feb 18;6(3):e70111. doi: 10.1002/mco2.70111. PMID: 39974665; PMCID: PMC11835948.

Towards an understanding of physical activity-induced post-exertional malaise: Insights into microvascular alterations and immunometabolic interactions in post-COVID condition and myalgic encephalomyelitis/chronic fatigue syndrome Haunhorst S, Dudziak D, Scheibenbogen C, Seifert M, Sotzny F, Finke C, Behrends U, Aden K, Schreiber S, Brockmann D, Burggraf P, Bloch W, Ellert C, Ramoji A, Popp J, Reuken P, Walter M, Stallmach A, Puta C. Infection. 2025 Feb;53(1):1-13. doi: 10.1007/s15010-024-02386-8. Epub 2024 Sep 6. PMID: 39240417; PMCID: PMC11825644.

Guidelines for preparation and flow cytometry analysis of human nonlymphoid tissue DC. Dudziak D, Heger L, Agace WW, Bakker J, de Gruijl TD, Dress RJ, Dutertre CA, Fenton TM, Fransen MF, Ginhoux F, Heyman O, Horev Y, Hornsteiner F, Kandiah V, Kles P, Lubin R, Mizraji G, Prokopi A, Saar O, Sopper S, Stoitzner P, Strandt H, Sykora MM, Toffoli EC, Tripp CH, van Pul K, van de Ven R, Wilensky A, Yona S, Zelle-Rieser C. Eur J Immunol. 2025 Jan;55(1):e2250325. doi: 10.1002/eji.202250325. Epub 2024 Dec 12. PMID: 39668411; PMCID: PMC11739683.

Beyond muscles: Investigating immunoregulatory myokines in acute resistance exercise - A systematic review and meta-analysis. Ringleb M, Javelle F, Haunhorst S, Bloch W, Fennen L, Baumgart S, Drube S, Reuken PA, Pletz MW, Wagner H, Gabriel HHW, Puta C. FASEB J. 2024 Apr 15;38(7):e23596. doi: 10.1096/fj.202301619R. PMID: 38597350.

The Neurobeachin-like 2 protein (NBEAL2) controls the homeostatic level of the ribosomal protein RPS6 in mast cells. Wegner P, Drube J, Ziegler L, Strotmann B, Marquardt R, Küchler C, Groth M, Nieswandt B, Andreas N, Drube S. Immunology. 2024 May;172(1):61-76. doi: 10.1111/imm.13756. Epub 2024 Jan 25. PMID: 38272677.

Anti-CD19 CAR-T cells are effective in severe idiopathic Lambert-Eaton myasthenic syndrome. Wickel J, Schnetzke U, Sayer-Klink A, Rinke J, Borie D, Dudziak D, Hochhaus A, Heger L, Geis C. Cell Rep Med. 2024 Nov 19;5(11):101794. doi: 10.1016/j.xcrm.2024.101794. Epub 2024 Oct 23. PMID: 39447569; PMCID: PMC11604532.

Oligoclonal CD4+CXCR5+ T cells with a cytotoxic phenotype appear in tonsils and blood. Liang C, Spoerl S, Xiao Y, Habenicht KM, Haeusl SS, Sandner I, Winkler J, Strieder N, Eder R, Stanewsky H, Alexiou C, Dudziak D, Rosenwald A, Edinger M, Rehli M, Hoffmann P, Winkler TH, Berberich-Siebelt F. Commun Biol. 2024 Jul 18;7(1):879. doi: 10.1038/s42003-024-06563-1. PMID: 39025930; PMCID: PMC11258247.

Protocol for mapping the heterogeneous dendritic cell network across the murine tissue landscape via high-dimensional flow cytometry.  Amon L, Seichter A, Vurnek D, Tchitashvili G, Heß I, Heger L, Lehmann CHK, Dudziak D. STAR Protoc. 2024 Sep 20;5(3):103151. doi: 10.1016/j.xpro.2024.103151. Epub 2024 Jul 9. PMID: 38990726; PMCID: PMC11295986.

Prosaposin hyperglycosylation: a novel tumor immune escape mechanism and implications for cancer immunotherapy. Peipp M, Dudziak D, Kellner C. Signal Transduct Target Ther. 2024 Jul 10;9(1):172. doi: 10.1038/s41392-024-01877-2. PMID: 38982080; PMCID: PMC11233631.

Pharmacodynamic Effect of mTOR Inhibition-based Immunosuppressive Therapy on T- and B-cell Subsets After Renal Transplantation. Wei X, Weber S, Yin D, Allabauer I, Jobst-Schwan T, Wiesener M, Schiffer M, Dudziak D, Lehmann CHK, Woelfle J, Hoerning A. Transplant Direct. 2024 Jun 20;10(7):e1666. doi: 10.1097/TXD.0000000000001666. PMID: 38911271; PMCID: PMC11191901.

Clec12A, CD301b, and FcγRIIB/III define the heterogeneity of murine DC2s and DC3s. Amon L, Seichter A, Vurnek D, Heger L, Lächele L, Tochoedo NR, Kaszubowski T, Hatscher L, Baranska A, Tchitashvili G, Nimmerjahn F, Lehmann CHK, Dudziak D. Cell Rep. 2024 Mar 26;43(3):113949. doi: 10.1016/j.celrep.2024.113949. Epub 2024 Mar 14. PMID: 38492222.

Förderung aktiver Mobilität im Alter durch Stadtgestaltung [Promoting active mobility in old age through urban design]. Baumgart S, Bolte G. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2024 Aug;67(8):910-920. German. doi: 10.1007/s00103-024-03922-5. Epub 2024 Jul 10. PMID: 38987453; PMCID: PMC11281947.

ATF3 characterizes aggressive drug-tolerant persister cells in HGSOC. Böpple K, Oren Y, Henry WS, Dong M, Weller S, Thiel J, Kleih M, Gaißler A, Zipperer D, Kopp HG, Aylon Y, Oren M, Essmann F, Liang C, Aulitzky WE. Cell Death Dis. 2024 Apr 24;15(4):290. doi: 10.1038/s41419-024-06674-x. PMID: 38658567; PMCID: PMC11043376.

Cat-E: A comprehensive web tool for exploring cancer targeting strategies. Salihoglu R, Balkenhol J, Dandekar G, Liang C, Dandekar T, Bencurova E. Comput Struct Biotechnol J. 2024 Mar 27;23:1376-1386. doi: 10.1016/j.csbj.2024.03.024. PMID: 38596315; PMCID: PMC11001601.

Attenuation of fibroblast activation and fibrosis by adropin in systemic sclerosis. Liang M, Dickel N, Györfi AH, SafakTümerdem B, Li YN, Rigau AR, Liang C, Hong X, Shen L, Matei AE, Trinh-Minh T, Tran-Manh C, Zhou X, Zehender A, Kreuter A, Zou H, Schett G, Kunz M, Distler JHW. Sci Transl Med. 2024 Mar 27;16(740):eadd6570. doi: 10.1126/scitranslmed.add6570. Epub 2024 Mar 27. PMID: 38536934.

Tissue niche occupancy determines the contribution of fetal- versus bone-marrow-derived macrophages to IgG effector functions. Wöhner M, Brechtelsbauer S, Friedrich N, Vorsatz C, Bulang J, Liang C, Schorr L, Beschin A, Guilliams M, Ravetch J, Nimmerjahn F, Biburger M. Cell Rep. 2024 Feb 27;43(2):113757. doi: 10.1016/j.celrep.2024.113757. Epub 2024 Feb 13. PMID: 38354088.

L-arginine metabolism inhibits arthritis and inflammatory bone loss. Cao S, Li Y, Song R, Meng X, Fuchs M, Liang C, Kachler K, Meng X, Wen J, Schlötzer-Schrehardt U, Taudte V, Gessner A, Kunz M, Schleicher U, Zaiss MM, Kastbom A, Chen X, Schett G, Bozec A. Ann Rheum Dis. 2024 Jan 2;83(1):72-87. doi: 10.1136/ard-2022-223626. PMID: 37775153; PMCID: PMC10803985.

Mutual Amplification of GLI2/Hedgehog and Transcription Factor JUN/AP-1 Signaling in Fibroblasts in Systemic Sclerosis: Potential Implications for Combined Therapies. Bergmann C, Chenguiti Fakhouri S, Trinh-Minh T, Filla T, Rius Rigau A, Ekici AB, Merlevede B, Hallenberger L, Zhu H, Dees C, Matei AE, Auth J, Györfi AH, Zhou X, Rauber S, Bozec A, Dickel N, Liang C, Kunz M, Schett G, Distler JHW. Arthritis Rheumatol. 2025 Jan;77(1):92-98. doi: 10.1002/art.42979. Epub 2024 Oct 20. PMID: 39187464; PMCID: PMC11684997.

ATP/IL-33-Co-Sensing by Mast Cells (MCs) Requires Activated c-Kit to Ensure Effective Cytokine Responses. Seifert J, Küchler C, Drube S. Cells. 2023 Nov 24;12(23):2696. doi: 10.3390/cells12232696. PMID: 38067124; PMCID: PMC10705958.

Interleukin-3 stabilizes CD124/IL-4α surface expression in mast cells via Tyk2 and STAT6. Drube S, Strotmann B, Wegner P, Jäger UM, Küchler C, Andreas N. Immunology. 2023 May;169(1):102-112. doi: 10.1111/imm.13614. Epub 2022 Dec 19. PMID: 36440951.

Immune cell profiling reveals natural killer and T cell subpopulations to be associated with atopic dermatitis severity. Worm M, Glatzel V, Baumgart S, Mei HE, Sörensen T, Grützkau A, Heine G. Clin Exp Allergy. 2023 Jan;53(1):105-108. doi: 10.1111/cea.14228. Epub 2022 Oct 13. PMID: 36102492.

Age-related changes of the innate immune system of the palatine tonsil in a healthy cohort. Andreas N, Geißler K, Priese J, Guntinas-Lichius O, Kamradt T. Front Immunol. 2023 Jun 29;14:1183212. doi: 10.3389/fimmu.2023.1183212. PMID: 37457697; PMCID: PMC10344772.

Persistent humoral and CD4+ TH cell immunity after mild SARS-COV-2 infection-The CoNAN long-term study. Schnizer C, Andreas N, Vivas W, Kamradt T, Baier M, Kiehntopf M, Glöckner S, Scherag A, Löffler B, Kolanos S, Guerra J, Pletz MW, Weis S. Front Immunol. 2023 Jan 13;13:1095129. doi: 10.3389/fimmu.2022.1095129. PMID: 36713390; PMCID: PMC9880277.

Mediterranean diet component oleic acid increases protective lipid mediators and improves trabecular bone in a Porphyromonas gingivalis inoculation model. Döding A, Hüfner M, Nachtsheim F, Iffarth V, Bölter A, Bastian A, Symmank J, Andreas N, Schädel P, Thürmer M, Becker K, Wolf M, Jacobs C, Kamradt T, Koeberle A, Werz O, Sigusch B, Schulze-Späte U. J Clin Periodontol. 2023 Mar;50(3):380-395. doi: 10.1111/jcpe.13751. Epub 2022 Dec 9. PMID: 36384158.

Unbiased high-dimensional flow cytometry identified NK and DC immune cell signature in Luminal A-type and triple negative breast cancer. Heger L, Heidkamp GF, Amon L, Nimmerjahn F, Bäuerle T, Maier A, Erber R, Hartmann A, Hack CC, Ruebner M, Huebner H, Fasching P, Beckmann MW, Dudziak D. Oncoimmunology. 2023 Dec 22;13(1):2296713. doi: 10.1080/2162402X.2023.2296713. PMID: 38170155; PMCID: PMC10761100.

Morphology as indicator of adaptive changes of model tissues in osmotically and chemically changing environments. Höllring K, Vurnek D, Gehrer S, Dudziak D, Hubert M, Smith AS. Biomater Adv. 2023 Nov;154:213635. doi: 10.1016/j.bioadv.2023.213635. Epub 2023 Sep 22. PMID: 37804683.

Editorial: Multiomics and multiparametric analyses to characterize myeloid cell subsets. Vu Manh TP, Dalod M, Dudziak D. Front Immunol. 2023 Sep 20;14:1292400. doi: 10.3389/fimmu.2023.1292400. PMID: 37799726; PMCID: PMC10548387.

BCL2 Inhibition Reveals a Dendritic Cell-Specific Immune Checkpoint That Controls Tumor Immunosurveillance. Zhao L, Liu P, Mao M, Zhang S, Bigenwald C, Dutertre CA, Lehmann CHK, Pan H, Paulhan N, Amon L, Buqué A, Yamazaki T, Galluzzi L, Kloeckner B, Silvin A, Pan Y, Chen H, Tian AL, Ly P, Dudziak D, Zitvogel L, Kepp O, Kroemer G. Cancer Discov. 2023 Nov 1;13(11):2448-2469. doi: 10.1158/2159-8290.CD-22-1338. PMID: 37623817; PMCID: PMC7615270.

XCR1 expression distinguishes human conventional dendritic cell type 1 with full effector functions from their immediate precursors. Heger L, Hatscher L, Liang C, Lehmann CHK, Amon L, Lühr JJ, Kaszubowski T, Nzirorera R, Schaft N, Dörrie J, Irrgang P, Tenbusch M, Kunz M, Socher E, Autenrieth SE, Purbojo A, Sirbu H, Hartmann A, Alexiou C, Cesnjevar R, Dudziak D. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2300343120. doi: 10.1073/pnas.2300343120. Epub 2023 Aug 11. PMID: 37566635; PMCID: PMC10438835.

Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1. Seeling M, Pöhnl M, Kara S, Horstmann N, Riemer C, Wöhner M, Liang C, Brückner C, Eiring P, Werner A, Biburger M, Altmann L, Schneider M, Amon L, Lehmann CHK, Lee S, Kunz M, Dudziak D, Schett G, Bäuerle T, Lux A, Tuckermann J, Vögtle T, Nieswandt B, Sauer M, Böckmann RA, Nimmerjahn F. Immunity. 2023 May 9;56(5):1046-1063.e7. doi: 10.1016/j.immuni.2023.02.019. Epub 2023 Mar 21. PMID: 36948194.

Circumventing pyroptosis via hyperactivation shapes superior immune responses of human type 2 dendritic cells compared to type 3 dendritic cells. Hatscher L, Kaszubowski T, Amon L, Dudziak D, Heger L. Eur J Immunol. 2023 Sep;53(9):e2250123. doi: 10.1002/eji.202250123. Epub 2023 Mar 14. PMID: 36724513.

Guidelines for DC preparation and flow cytometric analysis of human lymphohematopoietic tissues. Heger L, Dudziak D, Amon L, Hatscher L, Kaszubowski T, Lehmann CHK. Eur J Immunol. 2023 Dec;53(12):e2249917. doi: 10.1002/eji.202249917. Epub 2022 Dec 23. PMID: 36563130.

Guidelines for mouse and human DC functional assays. Clausen BE, Amon L, Backer RA, Berod L, Bopp T, Brand A, Burgdorf S, Chen L, Da M, Distler U, Dress RJ, Dudziak D, Dutertre CA, Eich C, Gabele A, Geiger M, Ginhoux F, Giusiano L, Godoy GJ, Hamouda AEI, Hatscher L, Heger L, Heidkamp GF, Hernandez LC, Jacobi L, Kaszubowski T, Kong WT, Lehmann CHK, López-López T, Mahnke K, Nitsche D, Renkawitz J, Reza RA, Sáez PJ, Schlautmann L, Schmitt MT, Seichter A, Sielaff M, Sparwasser T, Stoitzner P, Tchitashvili G, Tenzer S, Tochoedo NR, Vurnek D, Zink F, Hieronymus T. Eur J Immunol. 2023 Dec;53(12):e2249925. doi: 10.1002/eji.202249925. Epub 2022 Dec 23. PMID: 36563126.

Guidelines for DC preparation and flow cytometry analysis of mouse lymphohematopoietic tissues. Amon L, Dudziak D, Backer RA, Clausen BE, Gmeiner C, Heger L, Jacobi L, Lehmann CHK, Probst HC, Seichter A, Tchitashvili G, Tochoedo NR, Trapaidze L, Vurnek D. Eur J Immunol. 2023 Dec;53(12):e2249893. doi: 10.1002/eji.202249893. Epub 2022 Dec 23. PMID: 36563125.

Guidelines for DC preparation and flow cytometry analysis of mouse nonlymphoid tissues. Probst HC, Stoitzner P, Amon L, Backer RA, Brand A, Chen J, Clausen BE, Dieckmann S, Dudziak D, Heger L, Hodapp K, Hornsteiner F, Hovav AH, Jacobi L, Ji X, Kamenjarin N, Lahl K, Lahmar I, Lakus J, Lehmann CHK, Ortner D, Picard M, Roberti MP, Rossnagel L, Saba Y, Schalla C, Schlitzer A, Schraml BU, Schütze K, Seichter A, Seré K, Seretis A, Sopper S, Strandt H, Sykora MM, Theobald H, Tripp CH, Zitvogel L. Eur J Immunol. 2023 Nov;53(11):e2249819. doi: 10.1002/eji.202249819. Epub 2022 Dec 13. PMID: 36512638.

Guidelines for mouse and human DC generation. Lutz MB, Ali S, Audiger C, Autenrieth SE, Berod L, Bigley V, Cyran L, Dalod M, Dörrie J, Dudziak D, Flórez-Grau G, Giusiano L, Godoy GJ, Heuer M, Krug AB, Lehmann CHK, Mayer CT, Naik SH, Scheu S, Schreibelt G, Segura E, Seré K, Sparwasser T, Tel J, Xu H, Zenke M. Eur J Immunol. 2023 Nov;53(11):e2249816. doi: 10.1002/eji.202249816. Epub 2022 Oct 27. PMID: 36303448; PMCID: PMC10704271.

Functional Specialization of Dendritic Cell Subsets. Heger L, Amon L, Lehmann, C Baranska, A, Heidkamp G, Dudziak, D. Functional Specialization of Dendritic Cell Subsets. Encyclopedia of Cell Biology (Second Edition). Volume 5, 2023, Pages 446-471. DOI: 10.1016/B978-0-12-821618-7.00257-1.

Persistent T-Cell Reactivity in a Seronegative Patient after SARS-CoV-2 Infection and One Vaccination. Andreas N, Weis S, Kolanos S, Baumgart S, Kamradt T, Pletz MW. Vaccines (Basel). 2022 Jan 13;10(1):114. doi: 10.3390/vaccines10010114. PMID: 35062775; PMCID: PMC8780102.

A scoping review of regulatory T cell dynamics in convalescent COVID-19 patients - indications for their potential involvement in the development of Long COVID? Haunhorst S, Bloch W, Javelle F, Krüger K, Baumgart S, Drube S, Lemhöfer C, Reuken P, Stallmach A, Müller M, Zielinski CE, Pletz MW, Gabriel HHW, Puta C. Front Immunol. 2022 Dec 13;13:1070994. doi: 10.3389/fimmu.2022.1070994. PMID: 36582234; PMCID: PMC9792979.

The Heat Shock Protein 90 (HSP90) Is Required for the IL-33-Induced Cytokine Production in Mast Cells (MCs). Peters I, Müller S, Küchler C, Jäger U, Drube S. Int J Mol Sci. 2022 Sep 17;23(18):10855. doi: 10.3390/ijms231810855. PMID: 36142767; PMCID: PMC9502846.

Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells. Beyer M, Henninger SJ, Haehnel PS, Mustafa AM, Gurdal E, Schubert B, Christmann M, Sellmer A, Mahboobi S, Drube S, Sippl W, Kindler T, Krämer OH. Cell Chem Biol. 2022 Mar 17;29(3):398-411.e4. doi: 10.1016/j.chembiol.2021.10.011. Epub 2021 Nov 10. PMID: 34762849.

PRI: Re-Analysis of a Public Mass Cytometry Dataset Reveals Patterns of Effective Tumor Treatments. Hoang Y, Gryzik S, Hoppe I, Rybak A, Schädlich M, Kadner I, Walther D, Vera J, Radbruch A, Groth D, Baumgart S, Baumgrass R. Front Immunol. 2022 May 3;13:849329. doi: 10.3389/fimmu.2022.849329. PMID: 35592315; PMCID: PMC9110672.

Development of a new antigen-based microarray platform for screening and detection of human IgG antibodies against SARS-CoV-2. Burgold-Voigt S, Müller E, Zopf D, Monecke S, Braun SD, Frankenfeld K, Kiehntopf M, Weis S, Schumacher T, Pletz MW, Ehricht R; CoNAN Study Group. Sci Rep. 2022 May 16;12(1):8067. doi: 10.1038/s41598-022-10823-7. PMID: 35577791; PMCID: PMC9109672.

Destinations fostering older adults' walking for transport: a cross-sectional study from Germany. Hasselder P, Brüchert T, Baumgart S, Bolte G. BMC Geriatr. 2022 Mar 17;22(1):219. doi: 10.1186/s12877-022-02896-w. PMID: 35296266; PMCID: PMC8928617.

Osteoarthritis-Induced Metabolic Alterations of Human Hip Chondrocytes. Eitner A, Sparing S, Kohler FC, Müller S, Hofmann GO, Kamradt T, Schaible HG, Aurich M. Biomedicines. 2022 Jun 8;10(6):1349. doi: 10.3390/biomedicines10061349. PMID: 35740371; PMCID: PMC9220245.

Taz protects hematopoietic stem cells from an aging-dependent decrease in PU.1 activity. Kim KM, Mura-Meszaros A, Tollot M, Krishnan MS, Gründl M, Neubert L, Groth M, Rodriguez-Fraticelli A, Svendsen AF, Campaner S, Andreas N, Kamradt T, Hoffmann S, Camargo FD, Heidel FH, Bystrykh LV, de Haan G, von Eyss B. Nat Commun. 2022 Sep 3;13(1):5187. doi: 10.1038/s41467-022-32970-1. PMID: 36057685; PMCID: PMC9440927.

T Cell Response After SARS-CoV-2 Vaccination in Immunocompromised Patients with Inflammatory Bowel Disease. Reuken PA, Andreas N, Grunert PC, Glöckner S, Kamradt T, Stallmach A. J Crohns Colitis. 2022 Feb 23;16(2):251-258. doi: 10.1093/ecco-jcc/jjab147. PMID: 34379729; PMCID: PMC8385945.

High prevalence of long-term olfactory dysfunction confirmed by olfactory testing after a community COVID-19 outbreak. Gudziol H, Kirschstein T, Pletz MW, Weis S, Guntinas-Lichius O, Bitter T; CoNAN study group. HNO. 2021 Dec 23:1-8. doi: 10.1007/s00106-021-01129-7. Online ahead of print.

Complicated Long Term Vaccine Induced Thrombotic Immune Thrombocytopenia-A Case Report. Günther A, Brämer D, Pletz MW, Kamradt T, Baumgart S, Mayer TE, Baier M, Autsch A, Mawrin C, Schönborn L, Greinacher A, Thiele T. Vaccines (Basel). 2021 Nov 17;9(11):1344. doi: 10.3390/vaccines9111344.

Identification of a highly efficient dual type I/II FMS-like tyrosine kinase inhibitor that disrupts the growth of leukemic cells. Beyer M, Henninger SJ, Haehnel PS, Mustafa AM, Gurdal E, Schubert B, Christmann M, Sellmer A, Mahboobi S, Drube S, Sippl W, Kindler T, Krämer OH. Cell Chem Biol. 2021 Nov 9:S2451-9456(21)00475-X. doi: 10.1016/j.chembiol.2021.10.011. Online ahead of print.

Incidence and severity of G6PI-induced arthritis are not increased in genetically distinct mouse strains upon aging. Andreas N, Müller S, Templin N, Jordan PM, Schuhwerk H, Müller M, Gerstmeier J, Miek L, Andreas S, Werz O, Kamradt T. Arthritis Res Ther. 2021 Aug 24;23(1):222. doi: 10.1186/s13075-021-02596-7.

ATP/IL-33-triggered hyperactivation of mast cells results in an amplified production of pro-inflammatory cytokines and eicosanoids. Jordan PM, Andreas N, Groth M, Wegner P, Weber F, Jäger U, Küchler C, Werz O, Serfling E, Kamradt T, Dudeck A, Drube S. Immunology. 2021 Nov;164(3):541-554. doi: 10.1111/imm.13386. Epub 2021 Jun 30.

Lasp1 regulates adherens junction dynamics and fibroblast transformation in destructive arthritis. Beckmann D, Römer-Hillmann A, Krause A, Hansen U, Wehmeyer C, Intemann J, de Gorter DJJ, Dankbar B, Hillen J, Heitzmann M, Begemann I, Galic M, Weinhage T, Foell D, Ai R, Kremerskothen J, Kiener HP, Müller S, Kamradt T, Schröder C, Leitão E, Horsthemke B, Rosenstiel P, Nordström K, Gasparoni G, Gasparoni N, Walter J, Li N, Yang X, Chung HR, Pavenstädt H, Lindemann N, Schnittler HJ, Wang W, Firestein GS, Pap T, Korb-Pap A. Nat Commun. 2021 Jun 15;12(1):3624. doi: 10.1038/s41467-021-23706-8.

Tim-3 is dispensable for allergic inflammation and respiratory tolerance in experimental asthma. Boehne C, Behrendt AK, Meyer-Bahlburg A, Boettcher M, Drube S, Kamradt T, Hansen G. PLoS One. 2021 Apr 6;16(4):e0249605. doi: 10.1371/journal.pone.0249605. eCollection 2021.

Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells. Pekmezovic M, Hovhannisyan H, Gresnigt MS, Iracane E, Oliveira-Pacheco J, Siscar-Lewin S, Seemann E, Qualmann B, Kalkreuter T, Müller S, Kamradt T, Mogavero S, Brunke S, Butler G, Gabaldón T, Hube B. Nat Microbiol. 2021 May;6(5):643-657. doi: 10.1038/s41564-021-00875-2. Epub 2021 Mar 22.

Severe clinical relapse in an immunocompromised host with persistent SARS-CoV-2 infection. Reuken PA, Stallmach A, Pletz MW, Brandt C, Andreas N, Hahnfeld S, Löffler B, Baumgart S, Kamradt T, Bauer M. Leukemia. 2021 Mar;35(3):920-923. doi: 10.1038/s41375-021-01175-8. Epub 2021 Feb 19.

Targeting transdifferentiated hepatic stellate cells and monitoring the hepatic fibrogenic process by means of IGF2R-specific peptides designed in silico. Weber F, Casalini T, Valentino G, Brülisauer L, Andreas N, Koeberle A, Kamradt T, Contini A, Luciani P. J Mater Chem B. 2021 Mar 4;9(8):2092-2106. doi: 10.1039/d0tb02372h.

Inhibition of Inducible Nitric Oxide Synthase Prevents IL-1β-Induced Mitochondrial Dysfunction in Human Chondrocytes. Eitner A, Müller S, König C, Wilharm A, Raab R, Hofmann GO, Kamradt T, Schaible HG. Int J Mol Sci. 2021 Mar 1;22(5):2477. doi: 10.3390/ijms22052477.

IL-3 is essential for ICOS-L stabilization on mast cells, and sustains the IL-33-induced RORγt+ Treg generation via enhanced IL-6 induction. Drube S, Müller S, Weber F, Wegner P, Böttcher-Loschinski R, Gaestel M, Hutloff A, Kamradt T, Andreas N. Immunology. 2021 May;163(1):86-97. doi: 10.1111/imm.13305. Epub 2021 Jan 27.

Antibody response using six different serological assays in a completely PCR-tested community after a coronavirus disease 2019 outbreak-the CoNAN study. Weis S, Scherag A, Baier M, Kiehntopf M, Kamradt T, Kolanos S, Ankert J, Glöckner S, Makarewicz O, Hagel S, Bahrs C, Kimmig A, Proquitté H, Guerra J, Rimek D, Löffler B, Pletz MW; CoNAN Study Group. Clin Microbiol Infect. 2021 Mar;27(3):470.e1-470.e9. doi: 10.1016/j.cmi.2020.11.009. Epub 2020 Nov 20.

Mast cells initiate the vascular response to contact allergens by sensing cell stress. Hoppe A, Katsoulis-Dimitriou K, Edler HJ, Dudeck J, Drube S, Dudeck A. J Allergy Clin Immunol. 2020 May;145(5):1476-1479.e3. doi: 10.1016/j.jaci.2020.01.036. Epub 2020 Feb 1. PMID: 32018029.

The IL-33-induced p38-/JNK1/2-TNFalpha axis is antagonized by activation of beta-adrenergic-receptors in dendritic cells. Helbig C, Weber F, Andreas N, Herdegen T, Gaestel M, Kamradt T, Drube S. Sci Rep. 2020 May 18;10(1):8152. doi: 10.1038/s41598-020-65072-3. PMID: 32424229; PMCID: PMC7235212.

Identification of undescribed Relb expression domains in the murine brain by new Relb:cre-katushka reporter mice. Engelmann C, Riemann M, Carlstedt S, Grimlowski R, Andreas N, Koliesnik I, Meier E, Austerfield P, Haenold R. Dev Dyn. 2020 Aug;249(8):983-997. doi: 10.1002/dvdy.170. Epub 2020 May 30. PMID: 32145043.

The global response to the COVID-19 pandemic: how have immunology societies contributed? Osier F, Ting JPY, Fraser J, Lambrecht BN, Romano M, Gazzinelli RT, Bortoluci KR, Zamboni DS, Akbar AN, Evans J, Brown DE, Patel KD, Wu Y, Perez AB, Pérez O, Kamradt T, Falk C, Barda-Saad M, Ariel A, Santoni A, Annunziato F, Cassatella MA, Kiyono H, Chereshnev V, Dieye A, Mbow M, Mbengue B, Niang MDS, Suchard M. Nat Rev Immunol. 2020 Oct;20(10):594-602. doi: 10.1038/s41577-020-00428-4. Epub 2020 Sep 10. PMID: 32913283; PMCID: PMC7483049.

Editorial: IL-1 Family Members in Health and Disease. Brint E, Kamradt T, Doyle SL. Front Immunol. 2019 Nov 13;10:2596. doi: 10.3389/fimmu.2019.02596. PMID: 31798575; PMCID: PMC6863925.

Determination of the number of RAD51 molecules in different human cell lines. Foertsch F, Kache T, Drube S, Biskup C, Nasheuer HP, Melle C. Cell Cycle. 2019 Dec;18(24):3581-3588. doi: 10.1080/15384101.2019.1691802. Epub 2019 Nov 15. PMID: 31731884; PMCID: PMC6927726.

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Cossarizza A, Chang HD, Radbruch A, ... Kamradt T, ... Zychlinsky A. Eur J Immunol. 2019 Oct;49(10):1457-1973. doi: 10.1002/eji.201970107. PMID: 31633216; PMCID: PMC7350392.

IL-33-activated murine mast cells control the dichotomy between RORγt+ and Helios+ Tregs via the MK2/3-mediated IL-6 production in vitro. Andreas N, Weber F, Meininger I, Templin N, Gaestel M, Kamradt T, Drube S. Eur J Immunol. 2019 Dec;49(12):2159-2171. doi: 10.1002/eji.201948154. Epub 2019 Jul 30. PMID: 31334837.

What Are the Peripheral Blood Determinants for Increased Osteoclast Formation in the Various Inflammatory Diseases Associated With Bone Loss? de Vries TJ, El Bakkali I, Kamradt T, Schett G, Jansen IDC, D'Amelio P. Front Immunol. 2019 Mar 19;10:505. doi: 10.3389/fimmu.2019.00505. PMID: 30941138; PMCID: PMC6434996.

Contribution of Inflammation and Bone Destruction to Pain in Arthritis: A Study in Murine Glucose-6-Phosphate Isomerase-Induced Arthritis. Ebbinghaus M, Müller S, Segond von Banchet G, Eitner A, Wank I, Hess A, Hilger I, Kamradt T, Schaible HG. Arthritis Rheumatol. 2019 Dec;71(12):2016-2026. doi: 10.1002/art.41051. Epub 2019 Nov 9. PMID: 31332965.

Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation.Rao Z, Pace S, Jordan PM, Bilancia R, Troisi F, Börner F, Andreas N, Kamradt T, Menche D, Rossi A, Serhan CN, Gerstmeier J, Werz O. J Immunol. 2019 Aug 15;203(4):1031-1043. doi: 10.4049/jimmunol.1900236. Epub 2019 Jul 12. PMID: 31300512; PMCID: PMC7347291.

Sepsis induces long-lasting impairments in CD4+ T-cell responses despite rapid numerical recovery of T-lymphocyte populations. Ammer-Herrmenau C, Kulkarni U, Andreas N, Ungelenk M, Ravens S, Hübner C, Kather A, Kurth I, Bauer M, Kamradt T. PLoS One. 2019 Feb 7;14(2):e0211716. doi: 10.1371/journal.pone.0211716. PMID: 30730978; PMCID: PMC6366777.

RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells. Andreas N, Potthast M, Geiselhöringer AL, Garg G, de Jong R, Riewaldt J, Russkamp D, Riemann M, Girard JP, Blank S, Kretschmer K, Schmidt-Weber C, Korn T, Weih F, Ohnmacht C. J Immunol. 2019 Nov 15;203(10):2602-2613. doi: 10.4049/jimmunol.1801530. Epub 2019 Oct 2. PMID: 31578269; PMCID: PMC6826119.

Alternative NF-κB signaling controls peripheral homeostasis and function of regulatory T cells. Koliesnik IO, Andreas N, Thuy A, Sreekantapuram S, Haenold R, Weih F. Immunobiology. 2019 Sep;224(5):687-696. doi: 10.1016/j.imbio.2019.06.001. Epub 2019 Jun 7. PMID: 31200979.

A network of trans-cortical capillaries as mainstay for blood circulation in long bones Grüneboom A, Hawwari I, Weidner D, ... Müller S, ... Kamradt T, ... Gunzer M. Nat Metab 1, 236–250 (2019). https://doi.org/10.1038/s42255-018-0016-5

See also:

https://youtu.be/Tn0mPMrEZPo

PTPRG and PTPRC modulate nilotinib response in chronic myeloid leukemia cells. Drube J, Ernst T, Pfirrmann M, Albert BV, Drube S, Reich D, Kresinsky A, Halfter K, Sorio C, Fabisch C, Hochhaus A, Böhmer FD. Oncotarget. 2018 Jan 15;9(10):9442-9455. doi: 10.18632/oncotarget.24253. PMID: 29507701; PMCID: PMC5823647.

Gegenseitige Beeinflussung von Immunsystem und Knochen [Mutual influence of immune system and bones]. Kamradt T, Amling M, Dankbar B, Dudeck A, Gunzer M, Ignatius A, Krönke G, Kubatzky K, Pap T, Prinz I, Schett G, Schinke T, Tuckermann J, Waisman A. Z Rheumatol. 2018 May;77(Suppl 1):8-11. German. doi: 10.1007/s00393-018-0454-1. PMID: 29675686.

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice. Omata Y, Frech M, Primbs T, Lucas S, Andreev D, Scholtysek C, Sarter K, Kindermann M, Yeremenko N, Baeten DL, Andreas N, Kamradt T, Bozec A, Ramming A, Krönke G, Wirtz S, Schett G, Zaiss MM. Cell Rep. 2018 Jul 3;24(1):169-180. doi: 10.1016/j.celrep.2018.06.005. PMID: 29972778.

Forschungsverbund Neuroimmunologie und Schmerz (Neuroimpa) im Forschungsnetz Muskuloskelettale Erkrankungen [Research consortium Neuroimmunology and pain in the research network musculoskeletal diseases]. Schaible HG, Chang HD, Grässel S, Haibel H, Hess A, Kamradt T, Radbruch A, Schett G, Stein C, Straub RH. Z Rheumatol. 2018 May;77(Suppl 1):24-30. German. doi: 10.1007/s00393-018-0459-9. PMID: 29654392.

A new RelB-dependent CD117+ CD172a+ murine DC subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo.Andreas N, Riemann M, Castro CN, Groth M, Koliesnik I, Engelmann C, Sparwasser T, Kamradt T, Haenold R, Weih F. Eur J Immunol. 2018 Jun;48(6):923-936. doi: 10.1002/eji.201747332. Epub 2018 Apr 6. PMID: 29485182.

IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells.. Kulkarni U, Herrmenau C, Win SJ, Bauer M, Kamradt T. PLoS One. 2018 Feb 21;13(2):e0192304. doi: 10.1371/journal.pone.0192304. PMID: 29466409; PMCID: PMC5821326.

The p38-MK2/3 Module Is Critical for IL-33-Induced Signaling and Cytokine Production in Dendritic Cells.Göpfert C, Andreas N, Weber F, Häfner N, Yakovleva T, Gaestel M, Kamradt T, Drube S. J Immunol. 2018 Feb 1;200(3):1198-1206. doi: 10.4049/jimmunol.1700727. Epub 2017 Dec 29. PMID: 29288203.

RelB regulates Th17 differentiation in a cell-intrinsic manner.Koliesnik IO, Andreas N, Romanov VS, Sreekantapuram S, Krljanac B, Haenold R, Weih F. Immunobiology. 2018 Feb;223(2):191-199. doi: 10.1016/j.imbio.2017.10.026. Epub 2017 Oct 16. PMID: 29050819.

Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion. Minutti CM, Drube S, Blair N, Schwartz C, McCrae JC, McKenzie AN, Kamradt T, Mokry M, Coffer PJ, Sibilia M, Sijts AJ, Fallon PG, Maizels RM, Zaiss DM. Immunity. 2017 Oct 17;47(4):710-722.e6. doi: 10.1016/j.immuni.2017.09.013. PMID: 29045902; PMCID: PMC5654729.

The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis. Drube S, Grimlowski R, Deppermann C, Fröbel J, Kraft F, Andreas N, Stegner D, Dudeck J, Weber F, Rödiger M, Göpfert C, Drube J, Reich D, Nieswandt B, Dudeck A, Kamradt T. J Immunol. 2017 Oct 15;199(8):2948-2957. doi: 10.4049/jimmunol.1700556. Epub 2017 Sep 8. PMID: 28887433.

Interleukin-17A is involved in mechanical hyperalgesia but not in the severity of murine antigen-induced arthritis. Ebbinghaus M, Natura G, Segond von Banchet G, Hensellek S, Böttcher M, Hoffmann B, Salah FS, Gajda M, Kamradt T, Schaible HG. Sci Rep. 2017 Sep 4;7(1):10334. doi: 10.1038/s41598-017-10509-5. PMID: 28871176; PMCID: PMC5583382.

Automated Quantification of Early Bone Alterations and Pathological Bone Turnover in Experimental Arthritis by in vivo PET/CT Imaging. Hoffmann B, Svensson CM, Straßburger M, Gebser B, Irmler IM, Kamradt T, Peter Saluz H, Thilo Figge M. Sci Rep. 2017 May 22;7(1):2217. doi: 10.1038/s41598-017-02389-6. PMID: 28533505; PMCID: PMC5440413.

Time to follow up when comparing studies of pneumococcal vaccines. Pletz MW, Kamradt T, Welte T. Lancet Infect Dis. 2017 Mar;17(3):244-246. doi: 10.1016/S1473-3099(17)30051-8. Epub 2017 Jan 24. PMID: 28126328.

Quantification of arthritic bone degradation by analysis of 3D micro-computed tomography data. Svensson CM, Hoffmann B, Irmler IM, Straßburger M, Figge MT, Saluz HP. Sci Rep. 2017 Mar 14;7:44434. doi: 10.1038/srep44434. PMID: 28290525; PMCID: PMC5349516.

Membrane-bound stem cell factor is the major but not only driver of fibroblast-induced murine skin mast cell differentiation. Leist M, Sünder CA, Drube S, Zimmermann C, Geldmacher A, Metz M, Dudeck A, Maurer M. Exp Dermatol. 2017 Mar;26(3):255-262. doi: 10.1111/exd.13206. Epub 2017 Feb 9. PMID: 27619074.

Were Antibody Titers the Right Parameter When Immunologically Comparing Pneumococcal Vaccines? Pletz MW, Kamradt T, Forstner C, Welte T. Am J Respir Crit Care Med. 2016 Dec 15;194(12):1447-1448. doi: 10.1164/rccm.201607-1479ED. PMID: 27976946.

MK2/3 Are Pivotal for IL-33-Induced and Mast Cell-Dependent Leukocyte Recruitment and the Resulting Skin Inflammation. Drube S, Kraft F, Dudeck J, Müller AL, Weber F, Göpfert C, Meininger I, Beyer M, Irmler I, Häfner N, Schütz D, Stumm R, Yakovleva T, Gaestel M, Dudeck A, Kamradt T. J Immunol. 2016 Nov 1;197(9):3662-3668. doi: 10.4049/jimmunol.1600658. Epub 2016 Sep 30. PMID: 27694493.

Immunometabolism and autoimmunity. Freitag J, Berod L, Kamradt T, Sparwasser T. Immunol Cell Biol. 2016 Nov;94(10):925-934. doi: 10.1038/icb.2016.77. Epub 2016 Aug 26. PMID: 27562063.

Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction. Wehmeyer C, Frank S, Beckmann D, Böttcher M, Cromme C, König U, Fennen M, Held A, Paruzel P, Hartmann C, Stratis A, Korb-Pap A, Kamradt T, Kramer I, van den Berg W, Kneissel M, Pap T, Dankbar B. Sci Transl Med. 2016 Mar 16;8(330):330ra35. doi: 10.1126/scitranslmed.aac4351. Epub 2016 Mar 16. PMID: 27089204.

In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice. Eur Win SJ, Kühl AA, Sparwasser T, Hünig T, Kamradt T. J Immunol. 2016 May;46(5):1193-202. doi: 10.1002/eji.201546104. Epub 2016 Jan 20. PMID: 26711629.

IL-10 mediates plasmacytosis-associated immunodeficiency by inhibiting complement-mediated neutrophil migration. Kulkarni U, Karsten CM, Kohler T, Hammerschmidt S, Bommert K, Tiburzy B, Meng L, Thieme L, Recke A, Ludwig RJ, Pollok K, Kalies K, Bogen B, Boettcher M, Kamradt T, Hauser AE, Langer C, Huber-Lang M, Finkelman FD, Köhl J, Wong DM, Manz RA. J Allergy Clin Immunol. 2016 May;137(5):1487-1497.e6. doi: 10.1016/j.jaci.2015.10.018. Epub 2015 Dec 2. PMID: 26653800.

Simultaneous inhibition of JAK and SYK kinases ameliorates chronic and destructive arthritis in mice. Llop-Guevara A, Porras M, Cendón C, Di Ceglie I, Siracusa F, Madarena F, Rinotas V, Gómez L, van Lent PL, Douni E, Chang HD, Kamradt T, Román J. Arthritis Res Ther. 2015 Dec 10;17:356. doi: 10.1186/s13075-015-0866-0. PMID: 26653844; PMCID: PMC4675041.

TAK1 and IKK2, novel mediators of SCF-induced signaling and potential targets for c-Kit-driven diseases. Drube S, Weber F, Göpfert C, Loschinski R, Rothe M, Boelke F, Diamanti MA, Löhn T, Ruth J, Schütz D, Häfner N, Greten FR, Stumm R, Hartmann K, Krämer OH, Dudeck A, Kamradt T. Oncotarget. 2015 Oct 6;6(30):28833-50. doi: 10.18632/oncotarget.5008. PMID: 26353931; PMCID: PMC4745695.

TH1 and TH17 cells promote crescent formation in experimental autoimmune glomerulonephritis. Hünemörder S, Treder J, Ahrens S, Schumacher V, Paust HJ, Menter T, Matthys P, Kamradt T, Meyer-Schwesinger C, Panzer U, Hopfer H, Mittrücker HW. J Pathol. 2015 Sep;237(1):62-71. doi: 10.1002/path.4559. Epub 2015 Jun 11. PMID: 25965582.

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells. Drube S, Weber F, Loschinski R, Beyer M, Rothe M, Rabenhorst A, Göpfert C, Meininger I, Diamanti MA, Stegner D, Häfner N, Böttcher M, Reinecke K, Herdegen T, Greten FR, Nieswandt B, Hartmann K, Krämer OH, Kamradt T. Oncotarget. 2015 Mar 10;6(7):5354-68. doi: 10.18632/oncotarget.3022. PMID: 25749030; PMCID: PMC4467154.

Regulatorische T-Zellen und rheumatische Erkrankungen [Regulatory T cells and rheumatic diseases]. Humrich JY, Kamradt T, Riemekasten G. Z Rheumatol. 2015 Feb;74(1):26-32. German. doi: 10.1007/s00393-014-1446-4. PMID: 25676125.

Antagonism between granulocytic maturation and deacetylase inhibitor-induced apoptosis in acute promyelocytic leukaemia cells. Hennig D, Müller S, Wichmann C, Drube S, Pietschmann K, Pelzl L, Grez M, Bug G, Heinzel T, Krämer OH. Br J Cancer. 2015 Jan 20;112(2):329-37. doi: 10.1038/bjc.2014.589. Epub 2014 Dec 16. PMID: 25514379; PMCID: PMC4453449.

Towards the generation of B-cell receptor retrogenic mice. Freitag J, Heink S, Roth E, Wittmann J, Jäck HM, Kamradt T. PLoS One. 2014 Oct 8;9(10):e109199. doi: 10.1371/journal.pone.0109199. PMID: 25296340; PMCID: PMC4189916.

18 F-Fluoride positron emission tomography/computed tomography for noninvasive in vivo quantification of pathophysiological bone metabolism in experimental murine arthritis. Irmler IM, Gebhardt P, Hoffmann B, Opfermann T, Figge MT, Saluz HP, Kamradt T. Arthritis Res Ther. 2014 Jul 22;16(4):R155. doi: 10.1186/ar4670. PMID: 25053370; PMCID: PMC4220085.

Amelioration of experimental arthritis by stroke-induced immunosuppression is independent of Treg cell function. Irmler IM, Gajda M, Kamradt T. Ann Rheum Dis. 2014 Dec;73(12):2183-91. doi: 10.1136/annrheumdis-2013-204148. Epub 2013 Dec 10. PMID: 24326006; PMCID: PMC4251182.

Tim-3 is differently expressed in genetically susceptible C57BL/6 and resistant BALB/c mice during oral infection with Toxoplasma gondii. Berrocal Almanza LC, Muñoz M, Kühl AA, Kamradt T, Heimesaat MM, Liesenfeld O. Eur J Microbiol Immunol (Bp). 2013 Sep;3(3):211-21. doi: 10.1556/EuJMI.3.2013.3.10. Epub 2013 Sep 23. PMID: 24265941; PMCID: PMC3832097.

A complicated liaison: IL-33 and IL-33R in arthritis pathogenesis. Kamradt T, Drube S. Arthritis Res Ther. 2013;15(3):115. doi: 10.1186/ar4209. PMID: 23638884; PMCID: PMC3672742.

Abrogation of IL-4 receptor-α-dependent alternatively activated macrophages is sufficient to confer resistance against pulmonary cryptococcosis despite an ongoing T(h)2 response. Müller U, Stenzel W, Piehler D, Grahnert A, Protschka M, Köhler G, Frey O, Held J, Richter T, Eschke M, Kamradt T, Brombacher F, Alber G. Int Immunol. 2013 Aug;25(8):459-70. doi: 10.1093/intimm/dxt003. Epub 2013 Mar 26. PMID: 23532373.

IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. Huber M, Heink S, Pagenstecher A, Reinhard K, Ritter J, Visekruna A, Guralnik A, Bollig N, Jeltsch K, Heinemann C, Wittmann E, Buch T, Prazeres da Costa O, Brüstle A, Brenner D, Mak TW, Mittrücker HW, Tackenberg B, Kamradt T, Lohoff M. J Clin Invest. 2013 Jan;123(1):247-60. doi: 10.1172/JCI63681. Epub 2012 Dec 10. PMID: 23221338; PMCID: PMC3533283.

Schlechte Erinnerungen: pathogene Konsequenzen des immunologischen Gedächtnisses bei entzündlich rheumatischen Erkrankungen verstehen und beseitigen. Das IMPAM-Konsortium [Bad memories: understanding and removal of pathogenic consequences of immunological memory in inflammatory rheumatic diseases. The IMPAM consortium]. Kamradt T, Radbruch A, Chang HD. Z Rheumatol. 2012 Aug;71(6):501-3. German. doi: 10.1007/s00393-011-0920-5. PMID: 22802025.

Empfehlungen der Laborkommission der DGRh zur Weiterbildung von Rheumatologen auf dem Gebiet der rheumatologischen und immunologischen Labordiagnostik [Recommendations of the Laboratory Commission of the German Society of Rheumatology (DGRh) on further training of rheumatologists in the field of rheumatological and immunological laboratory diagnostics]. Dörner T, Hartung K, Burmester GR, Genth E, Kamradt T, Mierau R, Specker C, von Hinüber U. Z Rheumatol. 2012 Jun;71(4):328-9. German. doi: 10.1007/s00393-012-0976-x. PMID: 22552961.

Multivariate analysis of flow cytometric data using decision trees. Simon S, Guthke R, Kamradt T, Frey O. Front Microbiol. 2012 Apr 2;3:114. doi: 10.3389/fmicb.2012.00114. PMID: 22485112; PMCID: PMC3316995.

Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. Weber M, Lambeck S, Ding N, Henken S, Kohl M, Deigner HP, Enot DP, Igwe EI, Frappart L, Kiehntopf M, Claus RA, Kamradt T, Weih D, Vodovotz Y, Briles DE, Ogunniyi AD, Paton JC, Maus UA, Bauer M. FASEB J. 2012 Jun;26(6):2424-36. doi: 10.1096/fj.11-191957. Epub 2012 Mar 13. PMID: 22415311.

Osteoimmunologie - IMMUNOBONE - Das Wechselspiel zwischen Knochen und Immunsystem verstehen. Schwerpunktprogramm 1468 [Osteoimmunology - IMMUNOBONE - Understanding the interaction between bone and immune system]. Schett G, Pap T, Müller-Ladner U, Kamradt T. Z Rheumatol. 2012 Feb;71(2):138-9. German. doi: 10.1007/s00393-012-0954-3. PMID: 22370805.

Lack of IL-4 receptor expression on T helper cells reduces T helper 2 cell polyfunctionality and confers resistance in allergic bronchopulmonary mycosis. Müller U, Piehler D, Stenzel W, Köhler G, Frey O, Held J, Grahnert A, Richter T, Eschke M, Kamradt T, Brombacher F, Alber G. Mucosal Immunol. 2012 May;5(3):299-310. doi: 10.1038/mi.2012.9. Epub 2012 Feb 15. PMID: 22333910.

C-Kit controls IL-1β-induced effector functions in HMC-cells. Drube S, Schmitz F, Göpfert C, Weber F, Kamradt T.  Eur J Pharmacol. 2012 Jan 30;675(1-3):57-62. doi: 10.1016/j.ejphar.2011.11.035. Epub 2011 Dec 8. PMID: 22173128.

Th1-, Th17- und Th1+17-Zellen [Th1, Th17 and Th1+17 cells]. Chang HD, Kamradt T, Schulze-Koops H. Z Rheumatol. 2011 Dec;70(10):862-5. German. doi: 10.1007/s00393-011-0779-5. PMID: 22139205.

Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells. Baschant U, Frappart L, Rauchhaus U, Bruns L, Reichardt HM, Kamradt T, Bräuer R, Tuckermann JP. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19317-22. doi: 10.1073/pnas.1105857108. Epub 2011 Nov 14. PMID: 22084093; PMCID: PMC3228447.

Darmflora als Regulator des Immunsystems [Intestinal microbiota as regulator of the immune system]. Chang HD, Kamradt T. Z Rheumatol. 2011 Nov;70(9):790-2. German. doi: 10.1007/s00393-011-0907-2. PMID: 22038418.

B cell depletion reduces the number of autoreactive T helper cells and prevents glucose-6-phosphate isomerase-induced arthritis. Frey O, Bruns L, Morawietz L, Dunussi-Joannopoulos K, Kamradt T. PLoS One. 2011;6(9):e24718. doi: 10.1371/journal.pone.0024718. Epub 2011 Sep 8. PMID: 21931827; PMCID: PMC3169631.

Das adaptive Immunsystem [Adaptive immunity]. Kamradt T, Ferrari-Kühne K. Dtsch Med Wochenschr. 2011 Aug;136(33):1678-83. German. doi: 10.1055/s-0031-1281577. Epub 2011 Aug 10. PMID: 21833893.

Diversity and flexibility of Th17 effector functions. Kamradt T, Chang HD. Arthritis Res Ther. 2011 Apr 18;13(2):106. doi: 10.1186/ar3296. PMID: 21542876; PMCID: PMC3132042.

IL-33 shifts the balance from osteoclast to alternatively activated macrophage differentiation and protects from TNF-alpha-mediated bone loss. Zaiss MM, Kurowska-Stolarska M, Böhm C, Gary R, Scholtysek C, Stolarski B, Reilly J, Kerr S, Millar NL, Kamradt T, McInnes IB, Fallon PG, David JP, Liew FY, Schett G. J Immunol. 2011 Jun 1;186(11):6097-105. doi: 10.4049/jimmunol.1003487. Epub 2011 Apr 22. PMID: 21515798.

Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation. Ohno T, Oboki K, Morita H, Kajiwara N, Arae K, Tanaka S, Ikeda M, Iikura M, Akiyama T, Inoue J, Matsumoto K, Sudo K, Azuma M, Okumura K, Kamradt T, Saito H, Nakae S. PLoS One. 2011 Apr 11;6(4):e18404. doi: 10.1371/journal.pone.0018404. PMID: 21494550; PMCID: PMC3073971.

Implementation of 89Zr production and in vivo imaging of B-cells in mice with 89Zr-labeled anti-B-cell antibodies by small animal PET/CT.Walther M, Gebhardt P, Grosse-Gehling P, Würbach L, Irmler I, Preusche S, Khalid M, Opfermann T, Kamradt T, Steinbach J, Saluz HP. Appl Radiat Isot. 2011 Jun;69(6):852-7. doi: 10.1016/j.apradiso.2011.02.040. Epub 2011 Mar 2. PMID: 21397511.

PI3Kγ deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome. Berod L, Heinemann C, Heink S, Escher A, Stadelmann C, Drube S, Wetzker R, Norgauer J, Kamradt T. Eur J Immunol. 2011 Mar;41(3):833-44. doi: 10.1002/eji.201040504. Epub 2011 Feb 1. PMID: 21287545.

Ameliorated course of glucose-6-phosphate isomerase (G6PI)-induced arthritis in IFN-γ receptor knockout mice exposes an arthritis-promoting role of IFN-γ. Frey O, Mitera T, Kelchtermans H, Schurgers E, Kamradt T, Matthys P. J Autoimmun. 2011 Mar;36(2):161-9. doi: 10.1016/j.jaut.2010.12.006. Epub 2011 Jan 22. PMID: 21262564.

Biologika. Magic bullets - magic effects - magic costs? Neue Therapien und ihre (Aus-)Wirkungen [Biologics. Magic bullets - magic effects - magic costs? New therapeutics and their effects]. Frey O, Kamradt T. Ophthalmologe. 2011 Jan;108(1):7-12. German. doi: 10.1007/s00347-010-2255-z. PMID: 21253742.

Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit. Gerbaulet A, Wickenhauser C, Scholten J, Peschke K, Drube S, Horny HP, Kamradt T, Naumann R, Müller W, Krieg T, Waskow C, Hartmann K, Roers A. Blood. 2011 Feb 10;117(6):2012-21. doi: 10.1182/blood-2008-11-189605. Epub 2010 Dec 9. PMID: 21148330.

IFN-γ and IL-12 synergize to convert in vivo generated Th17 into Th1/Th17 cells. Lexberg MH, Taubner A, Albrecht I, Lepenies I, Richter A, Kamradt T, Radbruch A, Chang HD. Eur J Immunol. 2010 Nov;40(11):3017-27. doi: 10.1002/eji.201040539. PMID: 21061434.

In vivo molecular imaging of experimental joint inflammation by combined (18)F-FDG positron emission tomography and computed tomography. Irmler IM, Opfermann T, Gebhardt P, Gajda M, Bräuer R, Saluz HP, Kamradt T. Arthritis Res Ther. 2010;12(6):R203. doi: 10.1186/ar3176. Epub 2010 Nov 3. PMID: 21047399; PMCID: PMC3046507.

Histamine modulates γδ-T lymphocyte migration and cytotoxicity, via Gi and Gs protein-coupled signalling pathways. Truta-Feles K, Lagadari M, Lehmann K, Berod L, Cubillos S, Piehler S, Herouy Y, Barz D, Kamradt T, Maghazachi A, Norgauer J. Br J Pharmacol. 2010 Nov;161(6):1291-300. doi: 10.1111/j.1476-5381.2010.00639.x. PMID: 20977468; PMCID: PMC3000654.

Arthritis: where are the T cells? Kamradt T, Frey O. Arthritis Res Ther. 2010;12(3):122. doi: 10.1186/ar3008. Epub 2010 Jun 3. PMID: 20537200; PMCID: PMC2911865.

Inducible costimulator (ICOS) blockade inhibits accumulation of polyfunctional T helper 1/T helper 17 cells and mitigates autoimmune arthritis. Frey O, Meisel J, Hutloff A, Bonhagen K, Bruns L, Kroczek RA, Morawietz L, Kamradt T. Ann Rheum Dis. 2010 Aug;69(8):1495-501. doi: 10.1136/ard.2009.119164. Epub 2010 May 24. PMID: 20498202.

Regulatory T cells control the transition from acute into chronic inflammation in glucose-6-phosphate isomerase-induced arthritis. Frey O, Reichel A, Bonhagen K, Morawietz L, Rauchhaus U, Kamradt T. Ann Rheum Dis. 2010 Aug;69(8):1511-8. doi: 10.1136/ard.2009.123422. Epub 2010 May 24. PMID: 20498199.

The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells. Drube S, Heink S, Walter S, Löhn T, Grusser M, Gerbaulet A, Berod L, Schons J, Dudeck A, Freitag J, Grotha S, Reich D, Rudeschko O, Norgauer J, Hartmann K, Roers A, Kamradt T. Blood. 2010 May 13;115(19):3899-906. doi: 10.1182/blood-2009-10-247411. Epub 2010 Mar 3. PMID: 20200353.

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. Muñoz M, Heimesaat MM, Danker K, Struck D, Lohmann U, Plickert R, Bereswill S, Fischer A, Dunay IR, Wolk K, Loddenkemper C, Krell HW, Libert C, Lund LR, Frey O, Hölscher C, Iwakura Y, Ghilardi N, Ouyang W, Kamradt T, Sabat R, Liesenfeld O. J Exp Med. 2009 Dec 21;206(13):3047-59. doi: 10.1084/jem.20090900. Epub 2009 Dec 7. PMID: 19995958; PMCID: PMC2806449.

Plastizität der Effektorfunktionen von T-Helfer-Lymphozyten [Effector function plasticity of T helper lymphocytes]. Frey O, Kamradt T. Z Rheumatol. 2009 Dec;68(10):834-5. German. doi: 10.1007/s00393-009-0559-7. PMID: 19847446.

Immunization with an immunodominant self-peptide derived from glucose-6-phosphate isomerase induces arthritis in DBA/1 mice. Bruns L, Frey O, Morawietz L, Landgraf C, Volkmer R, Kamradt T. Arthritis Res Ther. 2009;11(4):R117. doi: 10.1186/ar2777. Epub 2009 Jul 29. PMID: 19640302; PMCID: PMC2745800.

Ncf1-associated reduced oxidative burst promotes IL-33R+ T cell-mediated adjuvant-free arthritis in mice. Hagenow K, Gelderman KA, Hultqvist M, Merky P, Bäcklund J, Frey O, Kamradt T, Holmdahl R. J Immunol. 2009 Jul 15;183(2):874-81. doi: 10.4049/jimmunol.0900966. Epub 2009 Jun 24. PMID: 19553535.

A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity. Huber M, Heink S, Grothe H, Guralnik A, Reinhard K, Elflein K, Hünig T, Mittrücker HW, Brüstle A, Kamradt T, Lohoff M. Eur J Immunol. 2009 Jul;39(7):1716-25. doi: 10.1002/eji.200939412. PMID: 19544308.

Lysophosphatidic acid inhibits the cytotoxic activity of NK cells: involvement of Gs protein-mediated signaling. Lagadari M, Truta-Feles K, Lehmann K, Berod L, Ziemer M, Idzko M, Barz D, Kamradt T, Maghazachi AA, Norgauer J. Int Immunol. 2009 Jun;21(6):667-77. doi: 10.1093/intimm/dxp035. Epub 2009 May 21. PMID: 19461126.

Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling. Lagadari M, Lehmann K, Ziemer M, Truta-Feles Krisztina, Berod Luciana, Idzko M, Barz D, Kamradt T, Maghazachi A, Norgauer J. (2009). International journal of oncology. 34. 287-94. Sphingosine-1-phosphate inhibits the cytotoxic activity of NK cells via Gs protein-mediated signalling. 

Th memory for interleukin-17 expression is stable in vivo. Lexberg MH, Taubner A, Förster A, Albrecht I, Richter A, Kamradt T, Radbruch A, Chang HD. Eur J Immunol. 2008 Oct;38(10):2654-64. doi: 10.1002/eji.200838541. PMID: 18825747.

Autoregulation of Th1-mediated inflammation by twist1.Niesner U, Albrecht I, Janke M, Doebis C, Loddenkemper C, Lexberg MH, Eulenburg K, Kreher S, Koeck J, Baumgrass R, Bonhagen K, Kamradt T, Enghard P, Humrich JY, Rutz S, Schulze-Topphoff U, Aktas O, Bartfeld S, Radbruch H, Hegazy AN, Löhning M, Baumgart DC, Duchmann R, Rudwaleit M, Häupl T, Gitelman I, Krenn V, Gruen J, Sieper J, Zeitz M, Wiedenmann B, Zipp F, Hamann A, Janitz M, Scheffold A, Burmester GR, Chang HD, Radbruch A. J Exp Med. 2008 Aug 4;205(8):1889-901. doi: 10.1084/jem.20072468. Epub 2008 Jul 28. PMID: 18663125; PMCID: PMC2525589.

Increased frequency of EBV-specific effector memory CD8+ T cells correlates with higher viral load in rheumatoid arthritis. Lünemann JD, Frey O, Eidner T, Baier M, Roberts S, Sashihara J, Volkmer R, Cohen JI, Hein G, Kamradt T, Münz C. J Immunol. 2008 Jul 15;181(2):991-1000. doi: 10.4049/jimmunol.181.2.991. PMID: 18606650; PMCID: PMC2570434.

Th17-Zellen [Th17 cells]. Kamradt T. Z Rheumatol. 2007 Feb;66(1):54-5. German. doi: 10.1007/s00393-007-0146-8. PMID: 17896424.

The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Brüstle A, Heink S, Huber M, Rosenplänter C, Stadelmann C, Yu P, Arpaia E, Mak TW, Kamradt T, Lohoff M. Nat Immunol. 2007 Sep;8(9):958-66. doi: 10.1038/ni1500. Epub 2007 Aug 5. PMID: 17676043.

Epstein-barr virus: environmental trigger of multiple sclerosis? Lünemann JD, Kamradt T, Martin R, Münz C. J Virol. 2007 Jul;81(13):6777-84. doi: 10.1128/JVI.00153-07. Epub 2007 Apr 25. PMID: 17459939; PMCID: PMC1933281.

Differential effects of ethanol on IFN-gamma- and TNF-alpha-producing splenic T lymphocytes in a murine model of gram-negative pneumonia. Lanzke N, Kleinwächter R, Kerschischnik S, Sargsyan L, Groneberg DA, Kamradt T, Liesenfeld O, Krenn V, Sander M, Spies C. Addict Biol. 2007 Mar;12(1):59-68. doi: 10.1111/j.1369-1600.2006.00042.x. PMID: 17407498.

Cutting Edge: Regulatory T cells prevent efficient clearance of Mycobacterium tuberculosis. Kursar M, Koch M, Mittrücker HW, Nouailles G, Bonhagen K, Kamradt T, Kaufmann SH. J Immunol. 2007 Mar 1;178(5):2661-5. doi: 10.4049/jimmunol.178.5.2661. PMID: 17312107.

Regulation of Protective and Pathogenic Th17 Responses Alber G, Kamradt T, Current Immunology Reviews (Discontinued); Volume 3, Issue 1, Year 2007, DOI: 10.2174/1573395510703010003

DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype.Durinovic-Belló I, Rosinger S, Olson JA, Congia M, Ahmad RC, Rickert M, Hampl J, Kalbacher H, Drijfhout JW, Mellins ED, Al Dahouk S, Kamradt T, Maeurer MJ, Nhan C, Roep BO, Boehm BO, Polychronakos C, Nepom GT, Karges W, McDevitt HO, Sønderstrup G. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11683-8. doi: 10.1073/pnas.0603682103. Epub 2006 Jul 25. PMID: 16868084; PMCID: PMC1544230.

Assessment of unspecific near-infrared dyes in laser-induced fluorescence imaging of experimental arthritis. Fischer T, Gemeinhardt I, Wagner S, Stieglitz DV, Schnorr J, Hermann KG, Ebert B, Petzelt D, Macdonald R, Licha K, Schirner M, Krenn V, Kamradt T, Taupitz M. Acad Radiol. 2006 Jan;13(1):4-13. doi: 10.1016/j.acra.2005.07.010. PMID: 16399028.

Chemotactic responses of IL-4-, IL-10-, and IFN-gamma-producing CD4+ T cells depend on tissue origin and microbial stimulus. Debes GF, Dahl ME, Mahiny AJ, Bonhagen K, Campbell DJ, Siegmund K, Erb KJ, Lewis DB, Kamradt T, Hamann A. J Immunol. 2006 Jan 1;176(1):557-66. doi: 10.4049/jimmunol.176.1.557. Erratum in: J Immunol. 2006 Feb 15;176(4):2671. PMID: 16365450.

Induction of a B-cell-dependent chronic arthritis with glucose-6-phosphate isomerase. Bockermann R, Schubert D, Kamradt T, Holmdahl R. Arthritis Res Ther. 2005;7(6):R1316-24. doi: 10.1186/ar1829. Epub 2005 Sep 20. PMID: 16277685; PMCID: PMC1297579.

Lipopolysaccharide injection induces relapses of experimental autoimmune encephalomyelitis in nontransgenic mice via bystander activation of autoreactive CD4+ cells. Nogai A, Siffrin V, Bonhagen K, Pfueller CF, Hohnstein T, Volkmer-Engert R, Brück W, Stadelmann C, Kamradt T. J Immunol. 2005 Jul 15;175(2):959-66. doi: 10.4049/jimmunol.175.2.959. PMID: 16002695.

Can infections prevent or cure allergy and autoimmunity? Kamradt T. Discov Med. 2005 Jun;5(27):283-7. PMID: 20704889.

Induction, exacerbation and inhibition of allergic and autoimmune diseases by infection. Kamradt T, Göggel R, Erb KJ. Trends Immunol. 2005 May;26(5):260-7. doi: 10.1016/j.it.2005.03.009. PMID: 15866239.

The role and clinical implications of G6PI in experimental models of rheumatoid arthritis. Kamradt T, Schubert D. Arthritis Res Ther. 2005;7(1):20-8. doi: 10.1186/ar1476. Epub 2004 Nov 30. PMID: 15642150; PMCID: PMC1064898.

Tracking of proinflammatory collagen-specific T cells in early and late collagen-induced arthritis in humanized mice.Svendsen P, Andersen CB, Willcox N, Coyle AJ, Holmdahl R, Kamradt T, Fugger L. J Immunol. 2004 Dec 1;173(11):7037-45. doi: 10.4049/jimmunol.173.11.7037. PMID: 15557201.

Cross-reactivity of T lymphocytes in infection and autoimmunity. Kamradt T, Volkmer-Engert R. Mol Divers. 2004;8(3):271-80. doi: 10.1023/b:modi.0000036236.11774.1b. PMID: 15384420.

Expression of selectin ligands on murine effector and IL-10-producing CD4+ T cells from non-infected and infected tissues.Kretschmer U, Bonhagen K, Debes GF, Mittrücker HW, Erb KJ, Liesenfeld O, Zaiss D, Kamradt T, Syrbe U, Hamann A. Eur J Immunol. 2004 Nov;34(11):3070-81. doi: 10.1002/eji.200424972. PMID: 15384048.

CC chemokine receptor 7 expression by effector/memory CD4+ T cells depends on antigen specificity and tissue localization during influenza A virus infection. Debes GF, Bonhagen K, Wolff T, Kretschmer U, Krautwald S, Kamradt T, Hamann A. J Virol. 2004 Jul;78(14):7528-35. doi: 10.1128/JVI.78.14.7528-7535.2004. PMID: 15220427; PMCID: PMC434070.

Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice. Schubert D, Maier B, Morawietz L, Krenn V, Kamradt T. J Immunol. 2004 Apr 1;172(7):4503-9. doi: 10.4049/jimmunol.172.7.4503. PMID: 15034067.

Autoantibodies against glucose-6-phosphate isomerase are not a diagnostic marker for juvenile idiopathic arthritis. Schmitt A, Schubert D, Sengler C, Kamradt T. Ann Rheum Dis. 2004 Apr;63(4):463. doi: 10.1136/ard.2003.014225. PMID: 15020348; PMCID: PMC1754952.

Two waves of antigen-containing dendritic cells in vivo in experimental Leishmania major infection. Misslitz AC, Bonhagen K, Harbecke D, Lippuner C, Kamradt T, Aebischer T. Eur J Immunol. 2004 Mar;34(3):715-725. doi: 10.1002/eji.200324391. PMID: 14991601.

Antigen-specific CD8+ T cell responses in intestinal tissues during murine listeriosis. Kursar M, Bonhagen K, Köhler A, Kamradt T, Kaufmann SH, Mittrücker HW. Microbes Infect. 2004 Jan;6(1):8-16. doi: 10.1016/j.micinf.2003.10.004. PMID: 14738888.