In our research group, we focus on the role of maternal vasculature in placenta-associated pregnancy disorders such as growth restriction and preeclampsia. In addition to our clinical studies on the endothelial health of mothers with placental disorders, we are conducting experimental studies in the laboratory on endothelial cell dysfunction and the interaction of trophoblast and endothelial cells. The subject of these studies is the interaction between endothelial and placental function and dysfunction. Because clinical findings indicate that women with pre-aged endothelial health are more likely to develop placenta-associated pregnancy complications, our current projects are investigating the association of cellular aging processes in endothelial cells and in the placenta with these pregnancy complications.
Because of the close association of endothelial and placental dysfunction with diabetes mellitus, our latest project focuses on investigating the specifics of placental function in patients with diabetes during pregnancy. As part of this, we are also analyzing our clinical data collected during the care of pregnant women with diabetes at our clinic's Center of Excellence for Diabetes and Pregnancy.