Mechanisms of vesicle formation in membrane trafficking processes
Synaptic transmission critically relies on effective and accurate compensatory endocytosis in presynaptic nerve endings. Syndapins belong to the superfamily of F-BAR domain proteins that detect and/or induce membrane curvatures. The increased extractability of dynamins - proteins that function in vesicle scission - after syndapin I deletion suggested that syndapin I acts as important factor for the recruitment and association of dynamin with membranes. The observed increase in synaptic vesicle diameters in presynaptic boutons might thus represent the consequence of delayed and ineffective dynamin-mediated vesicle fission upon syndapin I deficiency (Koch et al. 2011, EMBO J.). Our investigations thus lead to a deeper understanding of synaptic membrane trafficking processes and the role of syndapin I in these functions and furthermore allow to further unravel molecular mechanisms of neurotransmission and synaptic plasticity and their physiological importance.