Publikationen
2024
Fleischmann-Struzek, C., Rose, N., Ditscheid, B., Draeger, L., Dröge, P., Freytag, A., Goldhahn, L., Kannengießer, L., Kimmig, A., Matthäus-Krämer, C., Ruhnke, T., Reinhart, K., Schlattmann, P., Schmidt, K., Storch, J., Ulbrich, R., Ullmann, S., Wedekind, L., & Swart, E. Understanding health care pathways of patients with sepsis: protocol of a mixed-methods analysis of health care utilization, experiences, and needs of patients with and after sepsis. BMC Health Services Research 2024, 24(1), 40.
2023
Rose, N., Spoden, M., Freytag, A., Pletz, M., Eckmanns, T., Wedekind, L., Storch, J., Schlattmann, P., Hartog, C. S., Reinhart, K., Günster, C., & Fleischmann-Struzek, C. Association between hospital onset of infection and outcomes in sepsis patients – a propensity score matched cohort study based on health claims data in Germany. International Journal of Medical Microbiology, 2023, 151593.
Mellhammar, L., Wollter, E., Dahlberg, J., Donovan, B., Olséen, C.-J., Wiking, P. O., Rose, N., Schwarzkopf, D., Friedrich, M., Fleischmann-Struzek, C., Reinhart, K., & Linder, A. Estimating Sepsis Incidence Using Administrative Data and Clinical Medical Record Review. JAMA Network Open, 6(8), 2023, e2331168-e2331168.
Matthäus-Krämer C, Rose N, Spoden M, Pletz MW, Reinhart K, Fleischmann-Struzek C. Urban-rural disparities in case fatality of community-acquired sepsis in Germany: a retrospective cohort study. Int J Environ Res Public Health. 2023 May 18;20(10):5867.
Fleischmann-Struzek C, Ditscheid B, Rose N, Spoden M, Wedekind L, Schlattmann P, Günster C, Reinhart K, Hartog CS, Freytag A. Return to work after sepsis – A German population-based health claims study. Front Med (Lausanne). 2023 May 25;10:1187809.
Streich K, Hartog CS, Fleischmann-Struzek C, Rose N, Bichmann A, Esch M, Kesselmeier M, Schiefelhövel W, Schmieding M, Born S. Psychometric Properties of the Reintegration to Normal Living Index for sepsis survivors. Qual Life Res. 2023 Mar 30.
Born S, Matthäus-Krämer C, Bichmann A, Boltz H, Esch M, Heydt L, Sell S, Streich K, Scherag A, Reinhart K, Hartog CS, Fleischmann-Struzek C. Sepsis Survivors and Caregivers Perspectives on Post–Acute Rehabilitation and Aftercare in the First Year After Sepsis in Germany. Front Med (Lausanne). 2023 Apr 11;10:1137027.
Wedekind L, Fleischmann-Struzek C, Rose N, Spoden M, Günster C, Schlattmann P, Scherag A, Reinhart K, Schwarzkopf D. Development and validation of risk-adjusted quality indicators for long-term outcome of acute sepsis care in German hospitals based on administrative claims data. Front Med (Lausanne). 2023 Jan 9;9:1069042.
Born S, Matthäus-Krämer C, Reinhart K, Hartog CS, Fleischmann-Struzek C. Satisfaction Among Sepsis Survivors With the Information Received on Their Disease, Its Prevention, and Treatment. Dtsch Arztebl Int. 2023 Dec 15;120(50):871-872.
Born S, Fleischmann-Struzek C, Abels W, Piedmont S, Neugebauer E, Reinhart K, Toubekis E, Wegwarth O, Schwarzkopf D. Most patients with an increased risk for sepsis-related morbidity or death do not recognize sepsis as a medical emergency: results of a survey study using case vignettes. Crit Care. 2023 Nov 17;27(1):446.
Fleischmann-Struzek C, Rudd K. Challenges of assessing the burden of sepsis. Med Klin Intensivmed Notfmed. 2023 Dec;118(Suppl 2):68-74.
Schwarzkopf D, Rose N, Fleischmann-Struzek C, Boden B, Dorow H, Edel A, Friedrich M, Gonnert FA, Götz J, Gründling M, Heim M, Holbeck K, Jaschinski U, Koch C, Künzer C, Le Ngoc K, Lindau S, Mehlmann NB, Meschede J, Meybohm P, Ouart D, Putensen C, Sander M, Schewe JC, Schlattmann P, Schmidt G, Schneider G, Spies C, Steinsberger F, Zacharowski K, Zinn S, Reinhart K. Understanding the biases to sepsis surveillance and quality assurance caused by inaccurate coding in administrative health data. Infection. 2023 Sep 9. doi: 10.1007/s15010-023-02091-y.
2022
Winkler D, Rose N, Freytag A, Sauter W, Spoden M, Schettler A, Wedekind L, Storch J, Ditscheid B, Schlattmann P, Reinhart K, Günster C, Hartog CS, Fleischmann-Struzek C. The Effects of Post-acute Rehabilitation on Mortality, Chronic Care Dependency, Health Care Use and Costs in Sepsis Survivors. Ann Am Thorac Soc. 2022 Oct 17. doi: 10.1513/AnnalsATS.202203-195OC.
Debbeler LJ, Pohrt A, Fleischmann-Struek C, Schwarzkopf D, Born S, Reinhart K, Wegwarth O. Effect of Text-Based vs. Graphical Information Formats on Informed Choice in Sepsis Prevention and Early Detection: A Randomized Controlled Trial. J Clin Med. 2022 Jun 24;11(13):3659.
Fleischmann-Struzek C, Ditscheid B, Storch J, Rose N, Spoden M, Hartog CS, Freytag A. Evaluation of Infection-Related Hospitalizations and Drug Prescriptions Among Sepsis Survivors in Germany. JAMA Network Open. 2022;5(7):e2220945.
Spoden M, Hartog CS, Schlattmann P, Freytag A, Ostermann M, Wedekind L, Storch J, Reinhart K, Günster C, Fleischmann-Struzek C. Occurrence and Risk Factors for New Dependency on Chronic Care, Respiratory Support, Dialysis and Mortality in the First Year After Sepsis. Front Med (Lausanne). 2022 May 19;9:878337.
Schwarzkopf D, Rüddel H, Brinkmann A, Fleischmann-Struzek C, Friedrich ME, Glas M, Gogoll C, Gründling M, Meybohm P, Pletz M, Schreiber T, Thomas-Rueddel DO, Reinhart K. The German Quality Network Sepsis: evaluation of a quality collaborative on decreasing sepsis-related mortality in a quasi-experimental difference-in-differences design. Front. Med. 9:882340.
Fleischmann-Struzek C, Rose N, Born S, Freytag A, Ditscheid B, Storch J, Schettler A, Schlattmann P, Wedekind L, Pletz MW, Sänger S, Brunsmann F, Oehmichen F, Apfelbacher C, Drewitz P, Piedmont S, Denke C, Vollmar HC, Schmidt K, Landgraf I, Bodechtel U, Trumann A, Hecker R, Reinhart K, Hartog CS: White Paper - Verbesserung der Versorgungs- und Behandlungsangebote für Menschen mit Sepsis- und Infektionsfolgen. Dtsch Med Wochenschr 2022; 147(08): 485-491.
Stallmach A, Kesselmeier M, Bauer M, Gramlich J, Finke K, Fischer A, Fleischmann-Struzek C, Heutelbeck A, Mutschke S, Pletz M, Quickert S, Reinhart K, Stallmach Z, Walter M, Scherag A, Reuken P. Comparison of fatigue, cognitive dysfunction and psychological disorders in post-COVID patients and patients after sepsis: is there a specific constellation? Infection. 2022 Jan 7;1-9.
Fleischmann-Struzek C, Rose N, Freytag A, Spoden M, Prescott HC, Schettler A, Wedekind L, Dittscheid B, Storch J, Born S, Schlattmann P, Günster C, Reinhart K, Hartog CS. Epidemiology and Costs of Postsepsis Morbidity, Nursing Care Dependency, and Mortality in Germany, 2013 to 2017. JAMA Netw Open. 2021 Nov 1;4(11):e2134290.
Simpson, A, Long D, Fleischmann-Struzek C, Minogue J, Venkatesh B, Hammond NE, Tian DH, Schlapbach LJ. Long-term functional outcomes for adult and paediatric patients following sepsis – Protocol for a Systematic Review. Front Pediatr. 2021 Oct 25;9:734205.
Fleischmann-Struzek C, Rose N, Reinhart K. Sepsis-assoziierte Todesfälle in Deutschland: Charakteristika und regionale Variation. Fleischmann-Struzek C, Rose N, Reinhart K. Sepsisassoziierte Todesfälle in Deutschland: Charakteristika und regionale Variation [Sepsis-associated deaths in Germany: characteristics and regional variation]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2022;65(3):388-395.
Wedekind L, Fleischmann-Struzek C, Rose N, Spoden M, Günster C, Schlattmann P, Scherag A, Reinhart K, Schwarzkopf D. Development and validation of risk-adjusted quality indicators for the long-term outcome of acute sepsis care in German hospitals based on health claims data. Front Med (Lausanne). 2023 Jan 9;9:1069042.
2021
Fleischmann-Struzek C, Rose N, Freytag A, Spoden M, Prescott HC, Schettler A, Wdekind L, Ditscheid B, Storch J, Born S, Schlattmann P, Günster C, Reinhart K, Hartog CS. Epidemiology and costs of postsepsis morbidity, nursing care dependency, and mortality in Germany, 2013 to 2017. JAMA Netw Open 2021 Nov 1;4(11):e2134290.
Rose N, Matthäus-Krämer C, Schwarzkopf D, Scherag A, Born S, Reinhart K, Fleischmann-Struzek C. Association between sepsis incidence and regional socioeconomic characteristics and health care capacity in Germany – An ecological study. BMC Public Health. 2021 Sep 7;21(1):1636.
Storch J, Fleischmann-Struzek C, Rose N, Lehmann T, Mikolajetz A, Maddela S, Pletz MW, Forstner C, Wichmann O, Neufeind J, Vogel M, Reinhart K, Vollmar HC, Freytag A and the vaccination 60+ study group. The effect of influenza and pneumococcal vaccination in the elderly on health service utilization and costs: a claims data-based cohort study. European Journal of Health Economics Eur J Health Econ. 2021 Jul 20.
Karakike E, Giamarellos-Bourboulis EJ, Kyprianou M, Fleischmann-Struzek C, Pletz MW, Netea M, Reinhart K, Kyriazopoulou E. COVID-19 as cause of viral sepsis: A Systematic Review and Meta-Analysis. Crit Care Med. 2021 Jul 12.
Born S, Dame C, Matthäus-Krämer C, Reichert F, Schettler A, Schwarzkopf D, Thomas-Rüddel D, Proquitté H, Reinhart K, Fleischmann-Struzek C. Epidemiology of sepsis among children and neonates in Germany – analysis of nationwide DRG data between 2010 and 2016. Crit Care Med. 2021 Feb 23.
Fleischmann-Struzek C*, Kesselmeier M*, Ouart D*, Hartog CS, König C, Braune A, Einhorn C, Chkirni H, Born S, Töpfer K, Romeike H, Reinhart K and Scherag A, for the Mid-German Sepsis Cohort investigators. Cohort profile: The Mid-German Sepsis Cohort (MSC) – an observational patient cohort on long-term sequelae of sepsis survivors. BMJ Open. 2021 Mar 17;11(3):e043352.
Cassini A, Fleischmann-Struzek C, Naghavi M, Reinhart K, Allegranzi B and the WHO Sepsis Expert Technical Group: Future directions and priorities in sepsis epidemiology research: a Call for Action. Bull World Health Organ 2021;99:398–401
Fleischmann-Struzek C, Schwarzkopf D, Reinhart K. Inzidenz der Sepsis in Deutschland und weltweit - Eine Übersicht. Med Klin Intensivmed Notfmed. 2021 Jan 28:1-5.
Fleischmann-Struzek C, Reichert F, Cassini A, Horner R, Harder T, Kissoon N, Reinhart K, Allegranzi B, Eckmanns T. Global assessment of neonatal sepsis incidence and case fatality. Arch Dis Child 2021;0:1–8.
Rose N, Storch J, Mikolajetz A, Lehmann T, Reinhart K, Pletz M, Forstner C, Vollmar HC, Freytag A, Fleischmann-Struzek C. Preventive effects of influenza and pneumococcal vaccination in the elderly - Results from a population-based retrospective cohort study. Hum Vaccin Immunother. 2021 Jan 7;1-9.
2020
Schwarzkopf D, Fleischmann-Struzek C, Schlattmann P, Dorow H, Ouart D, Edel A, Gonnert FA, Götz J, Gründling M, Heim M, Jaschinski U, Meybohm P, Putensen C, Sander M, Reinhart K. Investigation of the validity of German inpatient administrative health data for epidemiological surveillance and measurement of quality of care for sepsis – the OPTIMISE study protocol. BMJ Open 2020;10:e035763
Schmidt K, Gensichen J, Bahr V, Fleischmann-Struzek C, Pausch Ch, Sakr Y, Reinhart K, Vollmar HC, Thiel P, Scherag A, Gantner J, Brunkhorst FM. Long-term survival following sepsis—results of a single-center registry study with four year follow-up. Arztebl Int 2020; 117: 775-82
Fleischmann-Struzek C, Mellhammar L, Rose N, Cassini A, Rudd KE, Schlattmann P, Allegranzi B, Reinhart K (2020). Global epidemiology of ICU- and hospital-treated sepsis – Update of a systematic review and meta-analysis of observational epidemiological studies. Intensive Care Medicine, 46(8), 1552-1562
Markwart R, Saito H, Harder T, Tomczyk S, Cassini A, Fleischmann-Struzek C, Reichert F, Eckmanns T, Allegranzi B (2020). The global burden of healthcare-associated sepsis: a systematic review and meta-analysis. Intensive Care Medicine 46, 1536–1551
Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, Fleischmann-Struzek C, Machado FR, Reinhart K, Rowan K, Seymour CW, Watson RS, West TE, Marinho F, Hay SI, Lozano R, Lopez AD, Angus DC, Murray CJL, Naghavi M. Global, regional, and national sepsis incidence and mortality, 1990–2017. Lancet 2020; 395: 200–11
Hartog CS, Bodechtel U, Fleischmann-Struzek C, Denke C, Weiss B, Reinhart K. [Sepsis: Sequelae for Affected Patients and The Health Care System]. Dtsch Med Wochenschr. 2020 Feb;145(4):252-259.
2019
Fleischmann-Struzek C, Mikolajetz A, Reinhart K, Curtis JR, Haase U, Hartog CS. Hospitalizations and ICU use in Germany from 2007 to 2015. Dtsch Arztebl Int 2019; 116: 653-60.
2018
Fleischmann-Struzek C, Mikolajetz A, Schwarzkopf D, Cohen J, Hartog CS, Pletz MW, Gastmeier P, Reinhart K. Challenges in Assessing the Burden of Sepsis and Understanding the Inequalities of Sepsis Outcomes between National Health Systems - Secular Trends in Sepsis and Infection Incidence and Mortality in Germany. Intensive Care Med (2018) 44:1826–1835
Eitze S, Fleischmann-Struzek C, Betsch C, Reinhart K. Determinants of sepsis knowledge: A representative survey of the elderly population in Germany. Crit Care. 2018 Oct 28;22(1):273.
Betsch C, Rossmann C, Pletz MW, Vollmar HC, Freytag A, Wichmann O, Hanke R, Heinemeier D, Schmid P, Eitze S, Weber W, Reinhardt A, Küpke NK, Neufeind J, Rieck T, Forstner C, Fleischmann-Struzek C, Mikolajetz A, Römhild J, Hanke W, Suchecka K, Reinhart K. Increasing influenza and pneumococcal vaccine uptake in the elderly: Study protocol for the multi-methods prospective intervention study Vaccination60+. BMC Public Health. 2018 Jul 16;18(1):885.
Fleischmann-Struzek C, Thomas-Rueddel TO, Schettler A, Schwarzkopf D, Stacke A, Seymour CW, Haas C, Dennler U, Reinhart K. Comparing the validity of different ICD coding abstraction strategies for sepsis case identification in German claims data. PLoS One. 2018 Jul 30;13(7):e0198847.
Schwarzkopf D, Fleischmann-Struzek C, Rüddel H, Reinhart K, Thomas-Rüddel DO. A risk model for hospital mortality among patients with severe sepsis or septic shock based on German national administrative claims data. PLoS One. 2018 Mar 20;13(3):e0194371
Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of pediatric and neonatal sepsis. Lancet Respir Med. 2018 Mar;6(3):223-230.
2017
Scherag A, Hartog CS, Fleischmann C, Ouart D, Hoffmann F, Kesselmeier M, Pöschmann S, Braune A, Eichhorn C, Gampe C, Romeike H, Reinhart K for the Mid-German Sepsis Cohort investigators. A patient cohort on long-term sequelae of sepsis survivors – the Mid-german Sepsis Cohort (MSC) study protocol. BMJ Open. 2017 Aug 23;7(8):e016827.
2016
Fleischmann C, Scherag A, Adhikari NK, Hartog CS, Tsaganos T, Schlattmann P, Angus DC, Reinhart K; International Forum of Acute Care Trialists. Assessment of Global Incidence and Mortality of Hospital-treated Sepsis - Current Estimates and Limitations. Am J Respir Crit Care Med. 2016 Feb 1;193(3):259-72.
Fleischmann C, Thomas-Rueddel DO, Hartmann M, Hartog CS, Welte T, Heublein S, Dennler U, Reinhart K. Hospital Incidence and Mortality Rates of Sepsis. Dtsch Arztebl Int. 2016 Mar 11;113(10):159-66.