Infection, inflammation and sepsis in cancer patients
Background
Infection, Inflammation and Immunological reactions are associated with cancer and cancer cells escape immune surveillance.
Research activities and expertise of groups at the HKI, JUH and the FSU in Jena focus on
- complement and immune evasion of tumor cells
- viral induced changes in pancreatic tumor cells
- crosstalk receptor tyrosinse kinases and toll like receptors
- vaccination strategies
- aoptosis and autophagy
Interdisciplinary Research Area click here
Coordinator
Participants
P. Zipfel - deputy director of the HKI (Complement cascade and factor H in cancer biology and escape from the immune system)
R. Kaufmann - JUH Clinic of General Surgery (Thrombin and proteinase activated receptors/PAR in cancer biology)
U. Settmacher - JUH Clinic of General Surgery (biology and treatment of hepatocellular carcinoma)
A. Stallmach - JUH Clinic of Gastroenterology (chronic bowel inflammation and colorectal cancer development)
M. Dürst - JUH Clinic of Gynecology (HPV in cervical carcinogenesis)
I. Petersen - JUH Institute of Pathology (Complement factor VIII in NSCLC, HPV as a marker in cancer diagnosis, PAR expression in cancer)
O. Guntinas-Lichius - JUH Clinic of Otorhinolaryngology (epidemiology and biology of HPV in head and neck carcinogenesis)
H. Sayer and P. La Rosée - JUH Department of Hematology and Oncology
Current status and expertise
- List of project drafts of principal investigators (PI) with external research funding and publication track records in the field (see below)
- Established collaboration, interaction and joint student seminars between the principal investigators and the different research groups at the Friedrich Schiller University (FSU)1, the Jena University Hospital (JUH)1, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute (HKI)2 and the Faculty for Biology and Pharmacy of the Friedrich-Schiller-University (FSU)
- Profound willingness for exchange of methods and expertise among the various PI and group members
Expertise (I)
- broad expertise in complement assays
- molecular and protein chemical expertise
- mouse models of autoimmune diseases
- interaction with clinically oriented groups
- model system for apoptosis and immune response
Expertise (II)
- cell models for macrophage plasticity
- vaccination approaches in model animals
- viral infection model
- histology
- digital image analyses
- cancer cytogenetics and cancer cell lines
Publications
- Zipfel PF, Skerka C. Complement regulators and inhibitory proteins. Nat Rev Immunol. 2009;9(10):729-40.
- Drube S, Heink S, Walter S, Löhn T, Grusser M, Gerbaulet A, Berod L, Schons J,Dudeck A, Freitag J, Grotha S, Reich D, Rudeschko O, Norgauer J, Hartmann K, Roers A, Kamradt T. The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells. Blood. 2010;115(19):3899-906.
- Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K; German Competence Network Sepsis (SepNet). Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008;358(2):125-39.
- Melle C, Ernst G, Winkler R, Schimmel B, Klussmann JP, Wittekindt C, Guntinas-Lichius O, von Eggeling F. Proteomic analysis of human papillomavirus-related oral squamous cell carcinoma: identification of thioredoxin and epidermal-fatty acid binding protein as upregulated protein markers in microdissected tumor tissue. Proteomics. 2009;9(8):2193-201.
- Kaufmann R, Rahn S, Pollrich K, Hertel J, Dittmar Y, Hommann M, Henklein P, Biskup C, Westermann M, Hollenberg MD, Settmacher U. Thrombin-mediated hepatocellular carcinoma cell migration: cooperative action via proteinase-activated receptors 1 and 4. J Cell Physiol. 2007;211(3):699-707.