Welcome to the internet presence of my working group. As a medical doctor, my main research focus is in the field of alveolar homeostasis and the pathogenesis of viral-bacterial interference. We mainly study influenza virus, Staphylococcus aureus and since March 2020 also SARS-CoV-2 associated diseases. A small excerpt of our projects can be found here.
If you have any questions, please contact me by email ( ).
Foto: Ebenbild Fotostudio, Jena
We established a novel immune-responsive model that reflects the complex crosstalk between pathogens and host. The in vitro model allows for the monitoring of spatiotemporal spreading of the pathogens and the characterization of morphological and functional alterations attributed to infection. The alveolus-on-a-chip represents a promising platform for mechanistic studies of host-pathogen interactions and the identification of molecular and cellular targets of novel treatment strategies in pneumonia.
Our publication was selected as "paper of the month" from the DGHM. https://www.dghm.org/aktuelles/paper-of-the-month/
The "Forschungscampus Jena InfectoGnostics" also published details about our work:
In cooperation with Dr. Sandor Nietzsche from the Center for Electron Microscopy, Jena University Hospital, we analyze co-infection between Influenza Virus and Staphylococcus aureus.
In cooperation with the Sectio of Surgical Pathology, Institute of Legal Medicine, Jena University Hospital we currently work on the mapping of SARS-CoV-2 in COVID-19 patients.
1: Schicke E, Cseresnyés Z, Rennert K, Vau V, Haupt KF, Hornung F, Nietzsche S,
Swiczak F, Schmidtke M, Glück B, Koch M, Schacke M, Heller R, Mosig AS, Figge MT,
Ehrhardt C, Löffler B, Deinhardt-Emmer S. Staphylococcus aureus Lung Infection
Results in Down-Regulation of Surfactant Protein-A Mainly Caused by
Pro-Inflammatory Macrophages. Microorganisms. 2020 Apr 16;8(4). pii: E577. doi:
10.3390/microorganisms8040577. PubMed PMID: 32316261.
2: Shittu A, Deinhardt-Emmer S, Vas Nunes J, Niemann S, Grobusch MP, Schaumburg
10.1111/tmi.13395. [Epub ahead of print] Review. PubMed PMID: 32219926.
3: Deinhardt-Emmer S, Rennert K, Schicke E, Cseresnyés Z, Windolph M, Nietzsche
S, Heller R, Siwczak F, Haupt KF, Carlstedt S, Schacke M, Figge MT, Ehrhardt C,
Löffler B, Mosig AS. Co-infection with Staphylococcus aureus after primary
influenza virus infection leads to damage of the endothelium in a human
alveolus-on-a-chip model. Biofabrication. 2020 Feb 19;12(2):025012. doi:
10.1088/1758-5090/ab7073. PubMed PMID: 31994489.
4: Deinhardt-Emmer S, Haupt KF, Garcia-Moreno M, Geraci J, Forstner C, Pletz M,
Ehrhardt C, Löffler B. Staphylococcus aureus Pneumonia: Preceding Influenza
Infection Paves the Way for Low-Virulent Strains. Toxins (Basel). 2019 Dec
17;11(12). pii: E734. doi: 10.3390/toxins11120734. PubMed PMID: 31861176; PubMed
Central PMCID: PMC6950557.
5: Hufsky F, Ibrahim B, Modha S, Clokie MRJ, Deinhardt-Emmer S, Dutilh BE, Lycett
S, Simmonds P, Thiel V, Abroi A, Adriaenssens EM, Escalera-Zamudio M, Kelly JN,
Lamkiewicz K, Lu L, Susat J, Sicheritz T, Robertson DL, Marz M. The Third Annual
Meeting of the European Virus Bioinformatics Center. Viruses. 2019 May 5;11(5).
pii: E420. doi: 10.3390/v11050420. PubMed PMID: 31060321; PubMed Central PMCID:
PMC6563321.
6: Tuchscherr L, Pöllath C, Siegmund A, Deinhardt-Emmer S, Hoerr V, Svensson CM,
Thilo Figge M, Monecke S, Löffler B. Clinical S. aureus Isolates Vary in Their
Virulence to Promote Adaptation to the Host. Toxins (Basel). 2019 Mar 1;11(3).
pii: E135. doi: 10.3390/toxins11030135. PubMed PMID: 30823631; PubMed Central
PMCID: PMC6468552.
7: Tuchscherr L, Korpos È, van de Vyver H, Findeisen C, Kherkheulidze S, Siegmund
A, Deinhardt-Emmer S, Bach O, Rindert M, Mellmann A, Sunderkötter C, Peters G,
Sorokin L, Löffler B. Staphylococcus aureus requires less virulence to establish
an infection in diabetic hosts. Int J Med Microbiol. 2018 Oct;308(7):761-769.
doi: 10.1016/j.ijmm.2018.05.004. Epub 2018 May 22. PubMed PMID: 29843979.
8: Hoerr V, Franz M, Pletz MW, Diab M, Niemann S, Faber C, Doenst T, Schulze PC,
Deinhardt-Emmer S, Löffler B. S. aureus endocarditis: Clinical aspects and
experimental approaches. Int J Med Microbiol. 2018 Aug;308(6):640-652. doi:
10.1016/j.ijmm.2018.02.004. Epub 2018 Feb 21. Review. PubMed PMID: 29526448.
9: Brunnemann AK*, Hoffmann A,* Deinhardt-Emmer S*, Nagel CH, Rose R, Fickenscher H,
Sauerbrei A, Krumbholz A. Relevance of non-synonymous thymidine kinase mutations
for antiviral resistance of recombinant herpes simplex virus type 2 strains.
Antiviral Res. 2018 Apr;152:53-57. doi: 10.1016/j.antiviral.2018.02.004. Epub
2018 Feb 7. PubMed PMID: 29427675.
10: Deinhardt-Emmer S, Höring S, Mura C, Hillemann D, Hermann B, Sachse S,
Bohnert J, Löffler B. First Time Isolation of Mycobacterium hassiacum From a
Respiratory Sample. Clin Med Insights Circ Respir Pulm Med. 2018 Jan
3;12:1179548417747529. doi: 10.1177/1179548417747529. eCollection 2018. PubMed
PMID: 29326536; PubMed Central PMCID: PMC5757423.
11: Deinhardt-Emmer S, Sachse S, Geraci J, Fischer C, Kwetkat A, Dawczynski K,
Tuchscherr L, Löffler B. Virulence patterns of Staphylococcus aureus strains from
nasopharyngeal colonization. J Hosp Infect. 2018 Nov;100(3):309-315. doi:
10.1016/j.jhin.2017.12.011. Epub 2017 Dec 15. PubMed PMID: 29253623.
12: Schleenvoigt BT, Pletz MW, Deinhardt-Emmer S, Sauerbrei A. Detection of a
novel mutation conferring acyclovir resistance and consecutive treatment failure
in an HIV-positive patient with recurrent HSV-2 infection. J Glob Antimicrob
Resist. 2018 Mar;12:20. doi: 10.1016/j.jgar.2017.11.009. Epub 2017 Nov 24. PubMed
PMID: 29179992.
13: Deinhardt-Emmer S, Hoerr V, Löffler B. Vascular graft infection: a new model
for treatment management? Future Microbiol. 2017 Jun;12:651-654. doi:
10.2217/fmb-2017-0068. Epub 2017 May 25. PubMed PMID: 28541093.
14: Brunnemann AK, Liermann K, Deinhardt-Emmer S, Maschkowitz G, Pohlmann A,
Sodeik B, Fickenscher H, Sauerbrei A, Krumbholz A. Recombinant herpes simplex
virus type 1 strains with targeted mutations relevant for aciclovir
susceptibility. Sci Rep. 2016 Jul 18;6:29903. doi: 10.1038/srep29903. PubMed
PMID: 27426251; PubMed Central PMCID: PMC4947914.
15: Sauerbrei A, Deinhardt S, Zell R, Wutzler P. Testing of herpes simplex virus
for resistance to antiviral drugs. Virulence. 2010 Nov-Dec;1(6):555-7. Epub 2010
Nov 1. PubMed PMID: 21178503.
16: Sauerbrei A, Deinhardt S, Zell R, Wutzler P. Phenotypic and genotypic
characterization of acyclovir-resistant clinical isolates of herpes simplex
virus. Antiviral Res. 2010 Jun;86(3):246-52. doi:
10.1016/j.antiviral.2010.03.002. Epub 2010 Mar 6. PubMed PMID: 20211650
Stefanie Deinhardt-Emmer
Female, born 1985 in Weimar, Germany Medical doctor
2 children (2013, 2014) Institute of Medical Microbiology
Phone: +49 3641 9393640
2004-11 Human Medicine, University of Jena (Germany), examination, Medical license M.D.
2011 Dr. med in Virology, Human Medicine, University of Jena,
2020 BMBF, “Verbesserung der mikrobiologischen Diagnostik von Staphylococcus aureus"
2019-23 Advanced clinician scientist scholarship (IZKF), UKJ
2018-19 Clinician Scientist scholarship, CSCC, UKJ
2015 Resident in Medical Microbiology, Jena University Hospital
2011-14 Resident, Internship at the Medical Clinics, Vessel Surgery/Haemato-oncology, Berlin
2020 Paper of the month, German Society for Hygiene and Microbiology (DGHM)
2020 Member of mentor program, universities Halle-Jena-Leipzig
2020 DGHM, Leipzig, talk
2019 Keynote lecture European Virus Bioninformatic Center, travel grant
2019 DGHM, Göttingen, talk
2018 Elected member of the board of directors of the Center of Sepsis Control and Care
2018 Keynote lecture 28th ECCMID congress Madrid, travel grant
2018 DFG “Infectiology” Meeting Uganda, Chair
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