Die Sektion Diabetologie der Klinik für Kinder- und Jugendmedizin beteiligt sich aktiv an der DPV-Initiative (Diabetes Patienten Verlaufsdokumentation) zur Qualitätssicherung und bei der gemeinsamen Auswertung der Daten im Rahmen der Versorgungsforschung.

Der Schwerpunkt der bei uns durchgeführten Auswertungen liegt bei der Früherkennung von Folgeerkrankungen bei Kindern und Jugendlichen mit Typ 1 Diabetes, insbesondere der Blutdruckregulation und der Auswirkung einer gestörten Blutdruckregulation auf die Entstehung mikro- und makroangiopathischer Komplikationen. Eine Auswahl unserer Arbeiten finden Sie unter Publikationen.

Darüber hinaus arbeiten wir aktiv mit an der Erstellung der Leitlinien Kinderdiabetologie der Arbeitsgemeinschaft Pädiatrische Diabetologie/Deutsche Diabetesgesellschaft.

Publikationen zu Diabetes und Blutdruck

• Dost A, Bechtold-Dalla Pozza S, Bollow E, Kovacic R, Vogel P, Feldhahn L, Schwab KO, Holl RW; Initiative DPV. Blood pressure regulation determined by ambulatory blood pressure profiles in children and adolescents with type 1 diabetes mellitus: Impact on diabetic complications. Pediatr Diabetes (2017) 18: 874-882.

• Hermann JM, Rosenbauer J, Dost A, Steigleder-Schweiger C, Kiess W, Schöfl C, Holl RW; DPV Initiative. Seasonal Variation in Blood Pressure in 162,135 Patients with Type 1 or Type 2 Diabetes Mellitus. J Clin Hypertens (Greenwich) (2016) 18: 270-278.

• Dost A, Molz E, Krebs A, Bechtold-Dalla Pozza S, Kapellen TM, Rohrer T, Raile K, Fritsch M, Schwab KO, Holl RW. Pulse pressure in children and adolescents with type 1 diabetes mellitus in Germany and Austria. Ped Diabetes (2014) 15: 236-243.

• Dost A, Dickgießer V, Holl RW, Kreuder JG. Blutdruckregulation und diabetische Nephropathie - Bedeutung bei Kindern und Jugendlichen mit Diabetes mellitus Typ 1. Diabetologe (2013) 9: 117-127.

• Dost A, Hofer S, Herbst A, Stachow R, Schober E, Müller UA, Holl RW. Factors contributing to terminal digital preference in 91 398 patients with diabetes mellitus in Germany and Austria: possible impact on therapeutic decisions. Diabetic Medicine (2009) 26:947–953.

• Knerr I, Dost A, Lepler R, Raile K, Schober E, Rascher W, Holl RW; on behalf of the DPV Scientific Initiative Germany and Austria. Tracking and prediction of arterial blood pressure from childhood to young adulthood in 868 patients with type 1 diabetes: A multi-center, longitudinal survey in Germany and Austria. Diabetes Care (2008) 31:726-727.

• Dost A., Klinkert , Kapellen T, Lemmer A, Naeke A, Grabert M, Kreuder J, Holl RW. Arterial hypertension determined by ambulatory blood pressure profiles: contribution to microalbuminuria risk in a nationwide multicenter investigation in 2105 children and adolescents with diabetes mellitus type 1. Diabetes Care (2008) 31:720-725.

Publikationen Diabetes allgemein (Auswahl)

• Neu A, Bürger-Büsing J, Danne T, Dost A, Holder M, Holl RW, Holterhus PM, Kapellen T, Karges B, Kordonouri O, Lange K, Müller S, Raile K, Schweizer R, Sengbusch SV, Stachow R, Wagner V, Wiegand S, Ziegler R. Diagnosis, Therapy and Follow-up of Diabetes Mellitus in Children and Adolescents. Exp Clin Endocrinol Diabetes (2019) 127: 341-352.

• Bohn B, Mönkemöller K, Hilgard D, Dost A, Schwab KO, Lilienthal E, Hammer E, Hake K, Fritsch M, Gohlke B, de Beaufort C, Holl RW; DPV-initiative. Oral contraception in adolescents with type 1 diabetes and its association with cardiovascular risk factors. A multicenter DPV study on 24 011 patients from Germany, Austria or Luxembourg. Pediatr Diabetes (2018) 19: 937-944.

• Nagl K, Hermann JM, Plamper M, Schröder C, Dost A, Kordonouri O, Rami-Merhar B, Holl RW. Factors contributing to partial remission in type 1 diabetes: analysis based on the insulin dose-adjusted HbA1c in 3657 children and adolescents from Germany and Austria. Pediatr Diabetes (2017) 18: 428-434.

• Dost A, Rohrer TR, Fröhlich-Reiterer E, Bollow E, Karges B, Böckmann A, Hamann J, RW Holl – for the DPV Initiative and the German Competence Network Diabetes Mellitus. Hyperthyroidism in 276 Children and Adolescents with Type 1 Diabetes from Germany and Austria. Horm Res Paediatr (2015) 84: 190-198.

• DuBose SN, Hermann JM, Tamborlane WV, Beck RW, Dost A, DiMeglio LA, Schwab KO, Holl RW, Hofer SE, Maahs DM; Type 1 Diabetes Exchange Clinic Network and Diabetes Prospective Follow-up Registry. Obesity in Youth with Type 1 Diabetes in Germany, Austria, and the United States. J Pediatr (2015) 167: 627-32.

• Boettcher C, Dost A, Wudy SA, Flechtner-Mors M, Borkenstein M, Schiel R, Weitzel D, Bechtold-Dalla Pozza S, Wolf J, Holl RW
  Accuracy of Blood Glucose Meters for Self-Monitoring Affects Glucose Control and Hypoglycemia Rate in Children and Adolescents with Type 1 Diabetes. Diabetes Technol Ther. (2015) 17: 275-282.

• Hofer SE, Raile K, Fröhlich-Reiterer E, Kapellen T, Dost A, Rosenbauer J, Grulich-Henn J, Holl RW; Austrian/German Diabetes Patienten Verlaufsdokumentation DPV Initiative; German Competence Network for Diabetes Mellitus. Tracking of metabolic control from childhood to young adulthood in type 1 diabetes. J Pediatr. (2014) 165: 956-961.

• Schwab KO, Doerfer J, Scheidt-Nave C, Hungele A, Scheuing N, Krebs A, Dost A, Rohrer T, Schober E, Holl RW. Diagnostic Algorithm for Individualized Lipid Monitoring According to Glycemic Control by Age, Gender, and Body Mass Index in 26,147 Children with Type 1 Diabetes and 14,057 Non-Diabetic Peers: Reference Values for LDL Cholesterol, Non-HDL Cholesterol, and HDL Cholesterol Derived from the German/Austrian Diabetes Documentation and Quality Management System (DPV) and the Health Interview and Examination Survey for Children and Adolescents (KiGGS). J Pediatr (2014) 164: 1079-1084.

• Bechtold S, Blaschek A, Raile K, Dost A, Freiberg C, Askenas M, Fröhlich-Reiter E, Holl RW. Higher relative risk for multiple sclerosis in a pediatric diabetes population: analysis from DPV data base. Diabetes Care (2014) 37: 96-101.

• Rosenbauer J, Dost A, Karges B, Hungele A, Stahl A, Bächle C, Gerstl EM, Kastendieck C, Hofer SE, Holl RW. Improved metabolic control in children and adolescents with type 1 diabetes– a trend analysis using prospective multi-centre data from Germany and Austria. Diabetes Care (2012) 35:80-86.