Functional dynamics of ion channels and transporters - DynIon -
The DFG-Research Unit initiative Functional dynamics of ion channels and transporters combines experimental and computational strategies to study ion channels and transporters. We will focus on ligand activation of ion channels, including ion channels that require ligand binding for channel opening (ionotropic glutamate receptors), ion channels that are modulated by ligands (K2P channels, voltage-gated K+ channels, cyclic nucleotide modulated ion channels) and transporters that can also adopt channel-like conformations (EAAT glutamate transporters and CLC anion channels/anion-proton exchangers). A variety of experimental approaches, ranging from electrophysiology, biochemistry and fluorometry to structural biology, will be integrated with computational techniques including all-atom molecular dynamics (MD), hybrid quantum mechanical/molecular mechanics simulations, as well as free energy calculations and Markov state modeling. Our strategy will foster and exploit an otherwise unattainable synergy between computer simulations and experiments. We expect that our research program will advance theoretical and experimental approaches in ion channel research in general and will provide novel insights into selected ion channels and transporters specifically.
Prof. Dr. Klaus Benndorf Friedrich-Schiller-Universität Jena Universitätsklinikum Jena Institut für Physiologie II Kollegiengasse 9, 07743 Jena Phone: +49 3641 9397651 E-mail:
Dr. Sonja Fey Friedrich-Schiller-Universität Jena Universitätsklinikum Jena Institut für Physiologie II Kollegiengasse 9, 07743 Jena Phone: +49 3641 9397664 E-mail: