Prof. Dr. Rainer König
Professor for Systems Biology of Sepsis
Integrated Research and Treatment Center
Center for Sepsis Control and Care (CSCC)
Jena University Hospital | Am Klinikum 1 | 07747 Jena | Deutschland
Tel: +49 3641 532 1189
Fax: +49 3641 532 0800
Major research topics
Pattern analysis on networks, alternative splicing detection using RNA sequencing data, detection of drug targets in metabolic networks of pathogens, flux balance analysis, regulatory network analysis
Scientific career
| Since March 2013 | Faculty position at the Jena University Hospital, group leader of the Bioinformatics group Systemsbiology of sepsis/König-Lab |
| Feb 07 – March 13 |
Research group leader at the Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg |
| Dec 04 – Feb 07 |
Postdoctoral researcher at the University of Heidelberg, Institute of Pharmacy and Molecular Biotechnology |
| Jan 2000 – Dec 04 |
Postdoctoral researcher at the German Cancer Research Center, Heidelberg |
| Sep 99 – Jan 2000 |
Teaching internship at the Bunsen-Gymnasium Heidelberg |
Education
| Dec 96 – Sep 99 | Pre-doctoral researcher at Heidelberg University and the European Molecular Biology Laboratory, (EMBL), Heidelberg |
| 1989 – 1996 | Studies in Physics and Mathematics at the Universities of Freiburg, Sussex (UK) and Heidelberg |
| 1993 | Bachelor final year project at the University of Sussex, UK |
Academic Degrees
| June 2010 | Habilitation (postdoctoral lecture qualification) in bioinformatics at the Faculty of Life Sciences, University of Heidelberg |
| 1999 | Dr. sc. hum. in biochemistry, Medical Faculty, University of Heidelberg |
| 1997 | State exam in mathematics and physics , University of Heidelberg |
| 1996 | Diploma degree in physics, University of Heidelberg |
Five selected publications
- Aschoff, M., Hotz-Wagenblatt, A., Glatting, K.H., Fischer, M., Eils, R. & König, R., SplicingCompass: differential splicing detection using RNA-Seq sequencing data (2013). Bioinformatics, 29, 1141.
- Kranz, A.L., Eils, R., König, R. (2011). Enhancers regulate progression of development in mammalian cells, Nucleic Acids Res., 39, 8689-702.
- Bauer T, Eils R, König R. (2011). RIP: the regulatory interaction predictor - a machine learning-based approach for predicting target genes of transcription factors, Bioinformatics, 27, 2239-47.
- Schramm, G., Wiesberg, S., Diessl, N., Kranz, A.L., Sagulenko, V., Oswald, M., Reinelt, G., Westermann, F., Eils, R. & König, R. (2010). PathWave: Discovering patterns of differentially regulated enzymes in metabolic pathways, Bioinformatics, 26, 1225-31.
- Lewis, N., Schramm, G., Bordbar, A.,Schellenberger, J., Andersen, M., Cheng, J., Patel, M., Yee, A., Lewis, R., Eils, R., König, R., Palsson, B. (2010). Formulating multi-cellular models of metabolism in tissues: application to energy metabolism in the human brain, Nat. Biotechnology, 28, 1279.