Animal models play a pivotal role in the understanding of the mechanisms for both development and resolution of sepsis-associated organ failure and of drug candidates involved therein. The Core Unit provides technical and methodical advice and assistance for animal models and replacement procedures for research projects in the CSCC. As a partner for consultations and collaborations, the Core Unit may provide support for the implementation and interpretation of in vivo and in vitro studies in individual projects. On the other hand, the Core Unit develops innovative strategies to improve preclinical sepsis research to a high level and to introduce replacement procedures. Additionally, it serves as a platform for the exchange of biomaterials from animal experiments (organ sharing). If necessary, this can be expanded by a corresponding database and storage of samples (Integrated Mouse Tissue and Data Warehouse - IMTDW). The experience in experimental sepsis research, especially in animal handling, will constantly be shared with all researchers particularly with junior staff.