Conference Room „Oval Office“ | Institute for Clinical Chemistry (building F5) | UKJ Jena University Hospital, Am Klinikum 1, 07747 Jena
- 11:00 Uhr
Seminars in Clinical Neurosciences
Speaker: Prof. Dr. Eckart Gundelfinger, Director, Leibniz Institute for Neurobiology Magdeburg | Head, Department of Neurochemistry and Molecular Biology
Topic: "How is life without Bassoon? – Impaired presynaptic function and its consequences for brain development, performance and disease"
Hosts: Prof. Otto W. Witte, Prof. Hans-Georg Schaible
The central goal of the research of Prof. Dr. Eckart Gundelfingers group is to appreciate molecular and cellular mechanisms of neuronal – in particular synaptic – plasticity in health and disease. The group studies i) chemical brain synapses and the dynamics of the synaptic proteome during memory formation, ii) the function of the perisynaptic extracellular matrix in physiological and pathological synaptic plasticity and iii) the synapto-genetics of the Drosophila larval neuromuscular junction (NMJ). In this context, the role of members of the neuroplastin-basigin subfamily of Iglike cell adhesion molecules in cellular signaling and Ca2+ homeostasis in the nervous and immune systems as well as at the fly NMJ attracted major interest. Moreover, synapto nuclear communication processes and the role of presynaptic mechanisms in learning and memory are being investigated.